D-P-METHYL SULFONE PHENYL ETHYL SERINATE

Product Name: D-P-METHYL SULFONE PHENYL ETHYL SERINATE
CAS No.: 36983-12-7
Chemical Name: D-P-METHYL SULFONE PHENYL ETHYL SERINATE
Synonyms: D-p-Methyl;Florfenicol Impurity 10;Acetildenafil Impurity 3;D-p-Methyl-sulfino phenyl ethyl;D- p-sulfoxylphenylserine ethyl;D-(4-Methylsulfonyl)phenylserineester;D-P-METHYL SULFONE PHENYL ETHYL SERITE;Ethyl D-4-(methylsulfinophenyl)serinate;D-P-METHYL SULFONE PHENYL ETHYL SERINATE;D-p-methyI sulfone phenyl ethyl serinate
CBNumber: CB1674479
Molecular Formula: C12H17NO5S
Formula Weight: 287.33
MOL File: 36983-12-7.mol

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D-P-METHYL SULFONE PHENYL ETHYL SERINATE Property

Melting point:: 135-137°C
Boiling point:: 515.0±50.0 °C(Predicted)
Density: 1.309
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform
form: Solid
pka: 10.57±0.45(Predicted)
color: White
optical activity: 1.00°(C=0.01g/mL, MEOH, 589nm)
InChI: InChI=1/C12H17NO5S/c1-3-18-12(15)10(13)11(14)8-4-6-9(7-5-8)19(2,16)17/h4-7,10-11,14H,3,13H2,1-2H3/t10-,11+/s3
InChIKey: CEEHCOWSYFANRT-WQVXQJEGNA-N
SMILES: [C@@H](C1C=CC(S(=O)(=O)C)=CC=1)(O)[C@@H](N)C(=O)OCC |&1:0,12,r|
CAS DataBase Reference: 36983-12-7

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M326190
Product name: D-p-MethylSulfonePhenylEthylSerinate
Packaging: 10g
Price: $1085
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0000854
Product name: D-PARA-METHYL SULFINO PHENYL ETHYL SERINATE
Purity: 95.00%
Packaging: 5MG
Price: $500.58
Updated: 2021/12/16

Activate Scientific

Product number: AS49130
Product name: D-P-Methyl sulfino phenyl ethyl serinate
Purity: 95% ee
Packaging: 25g
Price: $232
Updated: 2021/12/16

AK Scientific

Product number: A515
Product name: D-p-Methylsulfonephenylethylserinate
Packaging: 1g
Price: $21
Updated: 2021/12/16

Activate Scientific

Product number: AS49130
Product name: D-P-Methyl sulfino phenyl ethyl serinate
Purity: 95% ee
Packaging: 1g
Price: $32
Updated: 2021/12/16

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D-P-METHYL SULFONE PHENYL ETHYL SERINATE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Florfenicol intermediate.

Synthesis

5398-77-6

623-33-6

31925-27-6

GENERAL STEPS: 500 g (15.6 mol) of methanol was added to a 1000 ml three-necked flask. Under stirring conditions, 73.9 g (0.53 mol) of ethyl glycinate hydrochloride was added and the temperature was slowly raised to 50-55°C until the ethyl glycinate hydrochloride was completely dissolved. Subsequently, 67.5 g (0.27 mol) of copper sulfate pentahydrate was added to this solution and stirring was continued until complete dissolution and stirring was maintained at 50-55°C for 0.5 hr. Next, triethylamine was added dropwise to the reaction system and the pH was adjusted to 8.5-9.0. Then, 92 g (0.5 mol) of p-methylsulfonylbenzaldehyde was added, and the reaction temperature was maintained at 50-55 °C and the pH was maintained between 8.5-9.0 by adding triethylamine. During the reaction, the progress of the reaction was monitored by HPLC, and the reaction was judged to be complete when the percentage of peak area of p-methylsulfonylbenzaldehyde was less than 2%. At the end of the reaction, methanol was recovered by decompression distillation, and the temperature inside the reaction flask was controlled to be no more than 50 °C during the distillation process. After the recovery of methanol, 600 g of water was added to the reaction flask, and after sufficient stirring, 146.7 g of ethyl 3-(p-toluenesulfonylphenyl)serinate was obtained by centrifugation, with a moisture content of 10.0%, a purity of 97.2% and a yield of 92%.

References

[1] Patent: CN108373430, 2018, A. Location in patent: Paragraph 0017; 0040; 0045-0059

D-P-METHYL SULFONE PHENYL ETHYL SERINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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D-P-METHYL SULFONE PHENYL ETHYL SERINATE Suppliers

Canada 1 China 191 India 4 United States 8 Global 204

Hubei Xinkang Pharmaceutical Chemical Co., Ltd

Tel: 027-027-59308705 18871579363
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Beijing Isomersyn Technology CO;LTD

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Shanghai Sunway Pharmaceutical Technology Co., Ltd

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9ding chemical ( Shanghai) Limited

Tel: 4009209199
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Email: sales@9dingchem.com
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ProdList: 18209
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View Lastest Price from D-P-METHYL SULFONE PHENYL ETHYL SERINATE manufacturers

airuikechemical co., ltd.

Product: D-threo-beta-Methylsulfonylphenylserine ethyl ester 36983-12-7
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2024-04-07

Hebei Chuanghai Biotechnology Co,.LTD

Product: D-P-Methyl Sulfone Phenyl Ethyl Serinate 36983-12-7
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-23

Zhuozhou Wenxi import and Export Co., Ltd

Product: D-p-Methyl Sulfone Phenyl Ethyl Serinate 36983-12-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

36983-12-7, D-P-METHYL SULFONE PHENYL ETHYL SERINATERelated Search:

Thiamphenicol DL-Glutamine D(-)-Asparagine monohydrate D(-)-Glutamic acid D-Methionine D-(-)-Asparagine monohydrate (+)-Dibenzoyl-D-tartaric acid (1S,2S)-(+)-2-AMINO-3-METHOXY-1-PHENYL-1-PROPANOL D-P-METHYL SULFONE PHENYL ETHYL SERINATE (1S,2S)-(+)-2-AMINO-1-[4-(METHYLTHIO)PHENYL]-1,3-PROPANEDIOL (S)-3-Fluoro-pyrrolidine hydrochloride (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol METHYL (R)-3-HYDROXY-3-PHENYLPROPANOATE DL-THREO-3-PHENYLSERINE BETA-HYDROXY-4-(METHYLSULFONYL)-PHENYLALANINE ETHYL ESTER (2R,3S)-3-PHENYLSERINE (+)-ETHYL (R)-3-HYDROXY-3-PHENYLPROPIONATE

D-P-METHYL SULFONE PHENYL ETHYL SERINATE

Cuprum D-4-Methylsulfinophenylethylserinate

D-p-Methyl

D-p-Methyl-sulfino phenyl ethyl

D-p-Methyl sulfone phenyl ethyl serinate (d-PSE)

(S)--Hydroxy-4-(methylsulfonyl)-D-phenylalanine Ethyl Ester

D-threo--Methylsulfonylphenylserine Ethyl Ester

(S)-beta-Hydroxy-4-(methylsulfonyl)-D-Phenylalanine ethyl ester

D-threo-beta-Methylsulfonylphenylserine ethyl ester

(S)-ethyl 3-hydroxy-2-(4-(methylsulfonyl)phenylamino)propanoate

REF DUPL: D-4-Methylsulfonylphenyl serine ethyl ester

D-Phenylalanine, b-hydroxy-4-(Methylsulfonyl)-,ethyl ester, (bS)-

Ethyl D-4-(methylsulfinophenyl)serinate

(2R,3S)-Ethyl 2-amino-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propanoate

D-P-METHYL SULFONE PHENYL ETHYL SERITE

D-Para-Methyl Sulfone Phenyl Ethyl Serinate

D- p-sulfoxylphenylserine ethyl

D-Phenylalanine, β-hydroxy-4-(methylsulfonyl)-, ethyl ester, (βS)-

S)-beta-Hydroxy-4-(methylsulfonyl)-D-Phenylalanine ethyl este

D-p-methyI sulfone phenyl ethyl serinate

D-p-methylsulfonylphenylserine ethyl ester

1-[(1-Ethoxy-3-hydroxy-1-oxopropan-2-yl)-sulfinoamino]-4-methylbenzene

Acetildenafil Impurity 3

Florfenicol Impurity 10

D-(4-Methylsulfonyl)phenylserineester

36983-12-7

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36983-12-7