D-P-METHYL SULFONE PHENYL ETHYL SERINATE
- Product Name
- D-P-METHYL SULFONE PHENYL ETHYL SERINATE
- CAS No.
- 36983-12-7
- Chemical Name
- D-P-METHYL SULFONE PHENYL ETHYL SERINATE
- Synonyms
- D-p-Methyl;Florfenicol Impurity 10;Acetildenafil Impurity 3;D-p-Methyl-sulfino phenyl ethyl;D- p-sulfoxylphenylserine ethyl;D-(4-Methylsulfonyl)phenylserineester;D-P-METHYL SULFONE PHENYL ETHYL SERITE;Ethyl D-4-(methylsulfinophenyl)serinate;D-P-METHYL SULFONE PHENYL ETHYL SERINATE;D-p-methyI sulfone phenyl ethyl serinate
- CBNumber
- CB1674479
- Molecular Formula
- C12H17NO5S
- Formula Weight
- 287.33
- MOL File
- 36983-12-7.mol
D-P-METHYL SULFONE PHENYL ETHYL SERINATE Property
- Melting point:
- 135-137°C
- Boiling point:
- 515.0±50.0 °C(Predicted)
- Density
- 1.309
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform
- form
- Solid
- pka
- 10.57±0.45(Predicted)
- color
- White
- optical activity
- 1.00°(C=0.01g/mL, MEOH, 589nm)
- InChI
- InChI=1/C12H17NO5S/c1-3-18-12(15)10(13)11(14)8-4-6-9(7-5-8)19(2,16)17/h4-7,10-11,14H,3,13H2,1-2H3/t10-,11+/s3
- InChIKey
- CEEHCOWSYFANRT-WQVXQJEGNA-N
- SMILES
- [C@@H](C1C=CC(S(=O)(=O)C)=CC=1)(O)[C@@H](N)C(=O)OCC |&1:0,12,r|
- CAS DataBase Reference
- 36983-12-7
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M326190
- Product name
- D-p-MethylSulfonePhenylEthylSerinate
- Packaging
- 10g
- Price
- $1085
- Updated
- 2021/12/16
- Product number
- APN0000854
- Product name
- D-PARA-METHYL SULFINO PHENYL ETHYL SERINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.58
- Updated
- 2021/12/16
- Product number
- AS49130
- Product name
- D-P-Methyl sulfino phenyl ethyl serinate
- Purity
- 95% ee
- Packaging
- 25g
- Price
- $232
- Updated
- 2021/12/16
- Product number
- A515
- Product name
- D-p-Methylsulfonephenylethylserinate
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
- Product number
- AS49130
- Product name
- D-P-Methyl sulfino phenyl ethyl serinate
- Purity
- 95% ee
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
D-P-METHYL SULFONE PHENYL ETHYL SERINATE Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Florfenicol intermediate.
Synthesis
5398-77-6
623-33-6
31925-27-6
GENERAL STEPS: 500 g (15.6 mol) of methanol was added to a 1000 ml three-necked flask. Under stirring conditions, 73.9 g (0.53 mol) of ethyl glycinate hydrochloride was added and the temperature was slowly raised to 50-55°C until the ethyl glycinate hydrochloride was completely dissolved. Subsequently, 67.5 g (0.27 mol) of copper sulfate pentahydrate was added to this solution and stirring was continued until complete dissolution and stirring was maintained at 50-55°C for 0.5 hr. Next, triethylamine was added dropwise to the reaction system and the pH was adjusted to 8.5-9.0. Then, 92 g (0.5 mol) of p-methylsulfonylbenzaldehyde was added, and the reaction temperature was maintained at 50-55 °C and the pH was maintained between 8.5-9.0 by adding triethylamine. During the reaction, the progress of the reaction was monitored by HPLC, and the reaction was judged to be complete when the percentage of peak area of p-methylsulfonylbenzaldehyde was less than 2%. At the end of the reaction, methanol was recovered by decompression distillation, and the temperature inside the reaction flask was controlled to be no more than 50 °C during the distillation process. After the recovery of methanol, 600 g of water was added to the reaction flask, and after sufficient stirring, 146.7 g of ethyl 3-(p-toluenesulfonylphenyl)serinate was obtained by centrifugation, with a moisture content of 10.0%, a purity of 97.2% and a yield of 92%.
References
[1] Patent: CN108373430, 2018, A. Location in patent: Paragraph 0017; 0040; 0045-0059
D-P-METHYL SULFONE PHENYL ETHYL SERINATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from D-P-METHYL SULFONE PHENYL ETHYL SERINATE manufacturers
- Product
- D-threo-beta-Methylsulfonylphenylserine ethyl ester 36983-12-7
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2024-04-07
- Product
- D-P-Methyl Sulfone Phenyl Ethyl Serinate 36983-12-7
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-23
- Product
- D-p-Methyl Sulfone Phenyl Ethyl Serinate 36983-12-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26