ChemicalBook > CAS DataBase List > 4-AMINO-3-(TRIFLUOROMETHYL)PHENOL

4-AMINO-3-(TRIFLUOROMETHYL)PHENOL

Product Name: 4-AMINO-3-(TRIFLUOROMETHYL)PHENOL
CAS No.: 445-04-5
Chemical Name: 4-AMINO-3-(TRIFLUOROMETHYL)PHENOL
Synonyms: 3-(Trifluoromethyl)-4-aminophenol;2-Amino-5-hydroxybenzotrifluoride;4-AMINO-3-(TRIFLUOROMETHYL)PHENOL;Phenol, 4-amino-3-(trifluoromethyl)-;2-Amino-5-hydroxybenzotrifluoride 98%;4-Amino-3-(trifluoromethyl)phenol, 4-Hydroxy-2-(trifluoromethyl)aniline
CBNumber: CB1682377
Molecular Formula: C7H6F3NO
Formula Weight: 177.12
MOL File: 445-04-5.mol

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4-AMINO-3-(TRIFLUOROMETHYL)PHENOL Property

Melting point:: 158℃
Boiling point:: 275.9±40.0 °C(Predicted)
Density: 1.432±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 9.22±0.18(Predicted)
color: Off white to black

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Safety

HS Code: 2922290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: A576925
Product name: 4-Amino-3-(trifluoromethyl)phenol
Packaging: 10mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4856-3-42
Product name: 4-Amino-3-(trifluoromethyl)phenol
Purity: 98%
Packaging: 1g
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: 6140AB
Product name: 4-Amino-3-(trifluoromethyl)phenol
Packaging: 250mg
Price: $80
Updated: 2021/12/16

AK Scientific

Product number: 6140AB
Product name: 4-Amino-3-(trifluoromethyl)phenol
Packaging: 5g
Price: $192
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4856-3-42
Product name: 4-Amino-3-(trifluoromethyl)phenol
Purity: 98%
Packaging: 5G
Price: $195
Updated: 2021/12/16

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4-AMINO-3-(TRIFLUOROMETHYL)PHENOL Chemical Properties,Usage,Production

Synthesis

88-30-2

445-04-5

The general procedure for the synthesis of 4-amino-3-trifluoromethylphenol from 3-trifluoromethyl-4-nitrophenol was as follows: 10% palladium/carbon (Pd/C, 100 mg) was added to a 10 mL methanol (MeOH) solution of 4-nitro-3-(trifluoromethyl)phenol (Aldrich, 414 mg, 2.0 mmol). The reaction suspension was stirred under hydrogen (H2) atmosphere for 12 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum to afford 4-amino-3-(trifluoromethyl)phenol (350 mg, 95% yield), which was pure enough to be used in the subsequent reaction. Mass spectrum (ESI+): m/z 178.02 ([M + H]+).

References

[1] Journal of Heterocyclic Chemistry, 2011, vol. 48, # 3, p. 733 - 736
[2] Patent: US2005/245530, 2005, A1. Location in patent: Page/Page column 91
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 13, p. 3881 - 3891
[4] RSC Advances, 2013, vol. 3, # 11, p. 3697 - 3706
[5] Journal of the Chemical Society, 1949, p. 3016,3019

4-AMINO-3-(TRIFLUOROMETHYL)PHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-AMINO-3-(TRIFLUOROMETHYL)PHENOL manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-AMINO-3-(TRIFLUOROMETHYL)PHENOL 445-04-5
Price: US $1.00-28.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20000KG
Release date: 2024-07-29

Career Henan Chemical Co

Product: 4-Amino-3-(trifluoromethyl)phenol 445-04-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons
Release date: 2020-02-14

445-04-5, 4-AMINO-3-(TRIFLUOROMETHYL)PHENOLRelated Search:

4-METHOXY-1-NITRO-2-TRIFLUOROMETHYL-BENZENE 4-NITRO-3-(TRIFLUOROMETHYL)PHENOL 3-[4-NITRO-3-(TRIFLUOROMETHYL)PHENOXY]-2-THIOPHENECARBOXYLIC ACID 2-AMINO-5-METHOXYBENZOTRIFLUORIDE 4-AMINO-3-(TRIFLUOROMETHYL)PHENOL N-(2-[4-AMINO-3-(TRIFLUOROMETHYL)PHENOXY]ETHYL)-N-METHYL-N-PHENYLAMINE 1-NITRO-4-TRIFLUOROMETHOXY-2-TRIFLUOROMETHYL-BENZENE N-(3-[4-AMINO-3-(TRIFLUOROMETHYL)PHENOXY]PHENYL)-N,N-DIMETHYLAMINE 4-AMINO-2-(TRIFLUOROMETHYL)PHENOL 2-AMINO-4-(TRIFLUOROMETHYL)PHENOL HYDROCHLORIDE N-(1,1-DIMETHYL-2-PROPYNYL)-3-[4-NITRO-3-(TRIFLUOROMETHYL)PHENOXY]-2-THIOPHENECARBOXAMIDE LAMPRECIDE 5H-Benzocyclohepten-7-amine, 6,7,8,9-tetrahydro-N,N-dimethyl-5-(4-nitr o-3- (trifluoromethyl)phenoxy)-, cis- 5-NITRO-6-TRIFLUOROMETHYL-BENZO[1,3]DIOXOL-2-ONE METHYL 3-[4-NITRO-3-(TRIFLUOROMETHYL)PHENOXY]-2-THIOPHENECARBOXYLATE 2-METHOXY-5-AMINO-4-TRIFLUOMETHYL METHYL CARBOXYLATE 3-[4-NITRO-3-(TRIFLUOROMETHYL)PHENOXY]-N-PHENYL-2-THIOPHENECARBOXAMIDE N-(4-FLUOROPHENYL)-3-[4-NITRO-3-(TRIFLUOROMETHYL)PHENOXY]-2-THIOPHENECARBOXAMIDE

4-AMINO-3-(TRIFLUOROMETHYL)PHENOL

2-Amino-5-hydroxybenzotrifluoride 98%

4-Amino-3-(trifluoromethyl)phenol, 4-Hydroxy-2-(trifluoromethyl)aniline

2-Amino-5-hydroxybenzotrifluoride

3-(Trifluoromethyl)-4-aminophenol

Phenol, 4-amino-3-(trifluoromethyl)-

445-04-5

Phenol&Thiophenol&Mercaptan