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2-AMINO-5-METHOXYBENZOTRIFLUORIDE

Product Name
2-AMINO-5-METHOXYBENZOTRIFLUORIDE
CAS No.
53903-49-4
Chemical Name
2-AMINO-5-METHOXYBENZOTRIFLUORIDE
Synonyms
-AMINO-5-METHOXYBENZOTRIFLUORIDE;2-Aamino-5-ethoxybenzotrifluoride;2-AMINO-5-METHOXYBENZOTRIFLUORIDE;4-AMINO-3-(TRIFLUOROMETHYL)ANISOLE;5-METHOXY-2-AMINE-BENZOTRIFLUORIDE;4-METHOXY-2-(TRIFLUOROMETHYL)ANILINE;2-Amino-5-methoxybenzotrifluoride98%;2-Amino-5-methoxybenzotrifluoride 98%;4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLAMINE;4-methoxy-2-(trifluoromethyl)benzenamine
CBNumber
CB4281436
Molecular Formula
C8H8F3NO
Formula Weight
191.15
MOL File
53903-49-4.mol
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2-AMINO-5-METHOXYBENZOTRIFLUORIDE Property

Boiling point:
234.5±40.0 °C(Predicted)
Density 
1.280±0.06 g/cm3(Predicted)
refractive index 
1.4960
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
2.06±0.10(Predicted)
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C8H8F3NO/c1-13-5-2-3-7(12)6(4-5)8(9,10)11/h2-4H,12H2,1H3
InChIKey
BTRQZDUCUGJMPS-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(OC)C=C1C(F)(F)F
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
RIDADR 
2810
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
M332205
Product name
4-Methoxy-2-(trifluoromethyl)aniline
Packaging
100mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
066905
Product name
2-Amino-5-methoxybenzotrifluoride
Purity
98%
Packaging
25g
Price
$118
Updated
2021/12/16
Apolloscientific
Product number
PC2635
Product name
2-Amino-5-methoxybenzotrifluoride
Purity
98%
Packaging
25g
Price
$122
Updated
2021/12/16
SynQuest Laboratories
Product number
4830-3-X0
Product name
2-Amino-5-methoxybenzotrifluoride
Purity
98%
Packaging
25g
Price
$195
Updated
2021/12/16
SynQuest Laboratories
Product number
4830-3-X0
Product name
2-Amino-5-methoxybenzotrifluoride
Purity
98%
Packaging
5G
Price
$55
Updated
2021/12/16
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2-AMINO-5-METHOXYBENZOTRIFLUORIDE Chemical Properties,Usage,Production

Synthesis

344-39-8

53903-49-4

The general procedure for the synthesis of 2-amino-5-methoxybenzotrifluoride from 3-trifluoromethyl-4-nitroanisole was as follows:(b) Preparation of 4-methoxy-2-(trifluoromethyl)aniline by amination of 4-methoxy-2-(trifluoromethyl)nitrobenzene: In a 300 mL stainless steel autoclave, 25.0 g (0.11 mol) of 4-methoxy-2-(trifluoromethyl) nitrobenzene was dissolved in 150 mL of 95% ethanol. After purging the reactor with nitrogen, 1.1 g of 5% palladium-carbon catalyst was added and the autoclave was sealed. After purging with nitrogen again, the reactor was charged with 60 psi (413 kPa) hydrogen and stirring was started. During the reaction, the temperature was maintained between 25°C and 30°C by intermittent ice bath cooling. After approximately 90 minutes, hydrogen absorption was stopped. The pressure in the autoclave is released, flushed with nitrogen and opened. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give 22 g (100% yield) of a light yellow oily product identified as 4-methoxy-2-(trifluoromethyl)aniline.1H NMR analysis gave the following results: (δ, CDCl3) 7.82 (dd, J = 2 and 9 Hz, 1H), 7.00 (d, J = 2 Hz, 1H), 6.48 (d, J = 9 Hz, 1H ), 3.87 (br s, 2H) and 3.60 (s, 3H). Mass spectral analysis showed (m/e) 191 (M+), 176, 156, 128 and 52. The product was used directly in subsequent steps without further purification.

References

[1] Patent: US4879398, 1989, A
[2] Patent: CN107793413, 2018, A. Location in patent: Paragraph 0150; 0151; 0154; 0155
[3] Tetrahedron Letters, 2004, vol. 45, # 26, p. 5131 - 5133
[4] Journal of Medicinal Chemistry, 2009, vol. 52, # 7, p. 2109 - 2118
[5] Patent: WO2005/47273, 2005, A1. Location in patent: Page/Page column 44

2-AMINO-5-METHOXYBENZOTRIFLUORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-METHOXYBENZOTRIFLUORIDE Suppliers

China 74 Germany 3 India 1 Italy 1 Ukraine 1 United Kingdom 6 United States 12 Global 98
Nanjing ERan Biological Pharmaceutical Co., Ltd.
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13770809694
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Henan Weitixi Chemical Technology Co., Ltd
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0371-53370800 18037197114
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J & K SCIENTIFIC LTD.
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Alfa Aesar
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JinYan Chemicals(ShangHai) Co.,Ltd.
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Shanghai Harvest Chemical Industrial Co., Ltd.
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Beijing Eternalchem Co,. Ltd.
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010-59484199 18611897322
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Shanghai Sphchem Co., Ltd.
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021-5649-1756
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2819742715@qq.com
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Wuhan ariel chemical Co., LTD.
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18986259541
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View Lastest Price from 2-AMINO-5-METHOXYBENZOTRIFLUORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Methoxy-2-(trifluoromethyl)aniline 53903-49-4
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-10

53903-49-4, 2-AMINO-5-METHOXYBENZOTRIFLUORIDERelated Search:

4-METHOXY-1-NITRO-2-TRIFLUOROMETHYL-BENZENE 3-AMINO-4-METHOXYBENZOTRIFLUORIDE,2-METHOXY-5-TRIFLUOROMETHYL-PHENYLAMINE 5-AMINO-2-METHOXYBENZOTRIFLUORIDE, 98+%,3-AMINO-6-METHOXYBENZOTRIFLUORIDE,5-AMINO-2-METHOXYBENZOTRIFLUORIDE,5-amino-2-methoxybenzotrifluoride,97 3-Amino-5-methoxybenzotrifluoride 97%,3-Amino-5-methoxybenzotrifluoride97%,3-AMINO-5-METHOXYBENZOTRIFLUORIDE,3-METHOXY-5-TRIFLUOROMETHYL-PHENYLAMINE N-(3-[4-AMINO-3-(TRIFLUOROMETHYL)PHENOXY]PHENYL)-N,N-DIMETHYLAMINE N-(3-[4-AMINO-3-(TRIFLUOROMETHYL)PHENOXY]PROPYL)-N,N-DIMETHYLAMINE N-(2-[4-AMINO-3-(TRIFLUOROMETHYL)PHENOXY]ETHYL)-N-METHYL-N-PHENYLAMINE 1-NITRO-4-TRIFLUOROMETHOXY-2-TRIFLUOROMETHYL-BENZENE 2-AMINO-5-METHOXYBENZOTRIFLUORIDE 3-[4-NITRO-3-(TRIFLUOROMETHYL)PHENOXY]-2-THIOPHENECARBOXYLIC ACID 3-AMINO-2-METHOXYBENZOTRIFLUORIDE 3-[4-NITRO-3-(TRIFLUOROMETHYL)PHENOXY]-N-[4-(TRIFLUOROMETHYL)PHENYL]-2-THIOPHENECARBOXAMIDE 5H-Benzocyclohepten-7-amine, 6,7,8,9-tetrahydro-N,N-dimethyl-5-(4-nitr o-3- (trifluoromethyl)phenoxy)-, cis- N-(1,1-DIMETHYL-2-PROPYNYL)-3-[4-NITRO-3-(TRIFLUOROMETHYL)PHENOXY]-2-THIOPHENECARBOXAMIDE 4-(BENZYLOXY)-2-(TRIFLUOROMETHYL)ANILINE METHYL 3-[4-NITRO-3-(TRIFLUOROMETHYL)PHENOXY]-2-THIOPHENECARBOXYLATE 3-[4-NITRO-3-(TRIFLUOROMETHYL)PHENOXY]-N-PHENYL-2-THIOPHENECARBOXAMIDE 2-METHOXY-5-AMINO-4-TRIFLUOMETHYL METHYL CARBOXYLATE

  • 2-AMINO-5-METHOXYBENZOTRIFLUORIDE
  • 5-METHOXY-2-AMINE-BENZOTRIFLUORIDE
  • 4-METHOXY-2-(TRIFLUOROMETHYL)PHENYLAMINE
  • 4-METHOXY-2-(TRIFLUOROMETHYL)ANILINE
  • 2-Amino-5-methoxybenzotrifluoride 98%
  • 2-Amino-5-methoxybenzotrifluoride98%
  • 2-Aamino-5-ethoxybenzotrifluoride
  • 4-Amino-3-(trifluoromethyl)anisole, 4-Methoxy-2-(trifluoromethyl)aniline
  • 4-AMino-3-(trifluoroMethyl)anisole[2-AMino-5-Methoxybenzotrifluoride]
  • 4-Amino-3-(trifluoromethyl)anisole[4-Methoxy-2-(trifluoromethyl)benzenamine(92%)]
  • 4-AMINO-3-(TRIFLUOROMETHYL)ANISOLE
  • -AMINO-5-METHOXYBENZOTRIFLUORIDE
  • 4-methoxy-2-(trifluoromethyl)benzenamine
  • Benzenamine, 4-methoxy-2-(trifluoromethyl)-
  • 4-Methoxy-2-(trifluoromethyl)aniline,97%
  • 53903-49-4
  • Fluorine series
  • Aromatic Halides (substituted)