4-Methoxy-3-(trifluoromethyl)aniline

Product Name: 4-Methoxy-3-(trifluoromethyl)aniline
CAS No.: 393-15-7
Chemical Name: 4-Methoxy-3-(trifluoromethyl)aniline
Synonyms: TIMTEC-BB SBB002596;3-Amino-6-methoxybenzotriflo;3-TRIFLUOROMETHYL-P-ANISIDINE;3-Amino-6-methoxybenzotrifloride;4-Amino-2-trifluoromethylanisole;3-AMINO-6-METHOXYBENZOTRIFLUORIDE;3-Amino-6-methoxybenzotriflyoride;5-AMINO-2-METHOXYBENZOTRIFLUORIDE;5-Amino-2-methoxybenzotrifluoroide;3-trifluoromethyl-4-methoxyaniline
CBNumber: CB2145893
Molecular Formula: C8H8F3NO
Formula Weight: 191.15
MOL File: 393-15-7.mol

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4-Methoxy-3-(trifluoromethyl)aniline Property

Melting point:: 28 °C
Boiling point:: 112 °C
Density: 1.280±0.06 g/cm3(Predicted)
Flash point:: 112°C/18mm
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: solid
pka: 3.98±0.10(Predicted)
Appearance: Yellow to brown Solid
BRN: 2723972
InChI: InChI=1S/C8H8F3NO/c1-13-7-3-2-5(12)4-6(7)8(9,10)11/h2-4H,12H2,1H3
InChIKey: CQJCPOVTPNWVBW-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(OC)C(C(F)(F)F)=C1
CAS DataBase Reference: 393-15-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T,Xn
Risk Statements: 20/21/22-36/37/38-52-22
Safety Statements: 26-36/37/39
RIDADR: UN2811
Hazard Note: Irritant
HazardClass: TOXIC
HazardClass: 6.1
HS Code: 2922290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 001444
Product name: 4-Methoxy-3-(trifluoromethyl)aniline
Purity: 98%
Packaging: 25g
Price: $62
Updated: 2021/12/16

AK Scientific

Product number: Z0565
Product name: 5-Amino-2-methoxybenzotrifluoride
Packaging: 1g
Price: $64
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0024340
Product name: 5-AMINO-2-METHOXYBENZOTRIFLUORIDE
Purity: 95.00%
Packaging: 5G
Price: $815.43
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0024340
Product name: 5-AMINO-2-METHOXYBENZOTRIFLUORIDE
Purity: 95.00%
Packaging: 25G
Price: $1328.25
Updated: 2021/12/16

Oakwood

Product number: 005826
Product name: 4-Methoxy-3-(trifluoromethyl)aniline
Purity: 98%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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4-Methoxy-3-(trifluoromethyl)aniline Chemical Properties,Usage,Production

Uses

4-Methoxy-3-(trifluoromethyl)aniline is a fluorinated aniline derivative used as a pharmaceutical intermediate for the synthesis of antibacterial and antiparasitic quinoxaline-2,3-diamine derivatives.

Synthesis

654-76-2

393-15-7

The general procedure for the synthesis of 4-methoxy-3-trifluoromethylaniline using 2-methoxy-5-nitrobenzotrifluoride as starting material was as follows: 2-methoxy-5-nitrobenzotrifluoride (5.08 g, 23.0 mmol) was dissolved in methanol (200 mL), and 10% Pd-C catalyst (50% water, 250 mg) was added. The reaction mixture was stirred continuously for 3.5 h at room temperature and under atmospheric pressure hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated to dryness under reduced pressure to afford 4-methoxy-3-(trifluoromethyl)aniline (4.67 g, 100% yield). Results of mass spectrometry analysis: m/z = 192 ([M+H]+).

References

[1] Patent: EP1403255, 2004, A1. Location in patent: Page 121
[2] Patent: US2005/209260, 2005, A1. Location in patent: Page/Page column 143-144
[3] Patent: US2007/49609, 2007, A1. Location in patent: Page/Page column 122
[4] Synthesis, 2006, # 19, p. 3316 - 3340
[5] Patent: FR745293, 1932,

4-Methoxy-3-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Methoxy-3-(trifluoromethyl)aniline Suppliers

China 121 France 1 Germany 3 India 3 Ukraine 1 United Kingdom 13 United States 23 Global 165

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
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View Lastest Price from 4-Methoxy-3-(trifluoromethyl)aniline manufacturers

Honest Joy Holdings Limited

Product: 5-Amino-2-methoxybenzotrifluoride 393-15-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.8%
Supply Ability: 100 tons
Release date: 2022-02-21

Career Henan Chemical Co

Product: 5-AMINO-2-METHOXYBENZOTRIFLUORIDE 393-15-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KGS
Release date: 2019-12-31

393-15-7, 4-Methoxy-3-(trifluoromethyl)anilineRelated Search:

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3-TRIFLUOROMETHYL-P-ANISIDINE

5-AMINO-2-METHOXYBENZOTRIFLUORIDE

4-METHOXY-3-(TRIFLUOROMETHYL)ANILINE

TIMTEC-BB SBB002596

3-AMINO-6-METHOXYBENZOTRIFLUORIDE

5-amino-2-methoxybenzotrifluoride,97%

3-Amino-6-methoxybenzotriflyoride

3-Amino-6-methoxybenzotrifloride

5-AMINO-2-METHOXYBENZOTRIFLUORIDE, 98+%

4-Methoxy-3-(trifluoromethyl)aniline, 98+%

3-Amino-6-methoxybenzotriflo

4-Methoxy-3-(trifluoromethyl)aniline, 3-(Trifluoromethyl)-p-anisidine

4-Methoxy-3-trifluoroMethyl-phenylaMine

[4-methoxy-3-(trifluoromethyl)phenyl]amine hydrochloride

4-Amino-2-trifluoromethylanisole

5-Amino-2-methoxybenzotrifluoroide

Benzenamine, 4-methoxy-3-(trifluoromethyl)-

3-trifluoromethyl-4-methoxyaniline

393-15-7