ChemicalBook > CAS DataBase List > N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
- Product Name
- N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
- CAS No.
- 181629-93-6
- Chemical Name
- N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
- Synonyms
- SB 228357;SB-228357,SB228357;N-[3-fluoro-5-(3-pyridinyl)phenyl]-5-methoxy-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide;N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE;N-[3-Fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide;1H-Indole-1-carboxamide, N-[3-fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-
- CBNumber
- CB6716853
- Molecular Formula
- C22H17F4N3O2
- Formula Weight
- 431.38
- MOL File
- 181629-93-6.mol
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N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE Property
- Boiling point:
- 625.4±55.0 °C(Predicted)
- Density
- 1.398±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ~8 mg/mL, soluble
- form
- solid
- pka
- 9.72±0.70(Predicted)
- color
- white
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Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
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N-Bromosuccinimide Price
Tocris
- Product number
- 1375
- Product name
- SB228357
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $153
- Updated
- 2021/12/16
Tocris
- Product number
- 1375
- Product name
- SB228357
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $643
- Updated
- 2021/12/16
TRC
- Product number
- S155035
- Product name
- SB228357
- Packaging
- 25mg
- Price
- $305
- Updated
- 2021/12/16
Usbiological
- Product number
- 465900
- Product name
- SB 228357
- Packaging
- 10mg
- Price
- $453
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B6709
- Product name
- SB228357
- Packaging
- 10mg
- Price
- $291
- Updated
- 2021/12/16
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N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE Chemical Properties,Usage,Production
Uses
SB 228357 is a SR-2C/SR-2B receptor antagonist. It is used in the treatment of irritable bowel syndrome (IBS).
Definition
ChEBI: SB 228357 is an indolyl carboxylic acid.
Biological Activity
5-HT 2C/2B receptor antagonist (pK i values are 7.0, 8.1 and 9.1 at 5-HT 2A , 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT 2C receptor function. Orally active in vivo .
storage
Store at RT
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE Suppliers
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181629-93-6, N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDERelated Search:
6-METHYL-2,3-DIHYDRO-1H-INDOLE
3-Fluoro-5-methylaniline
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
5-AMINO-2-METHOXYBENZOTRIFLUORIDE
3-Pyridin-3-ylaniline
alpha,alpha,alpha-Trifluoro-o-cresol
2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE
4-Amino-2,5-dimethylphenol
4-AMINO-2-(TRIFLUOROMETHYL)PHENOL
6-(Trifluoromethyl)indoline
2-(TRIFLUOROMETHYL)ANISOLE