ChemicalBook > CAS DataBase List > N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE

N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE

Product Name
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
CAS No.
181629-93-6
Chemical Name
N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
Synonyms
SB 228357;SB-228357,SB228357;SB228357, 10 mM in DMSO;N-(3-Fluoro-5-(pyridin-3-yl)phenyl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide;N-[3-fluoro-5-(3-pyridinyl)phenyl]-5-methoxy-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide;N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE;N-[3-Fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide;1H-Indole-1-carboxamide, N-[3-fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-
CBNumber
CB6716853
Molecular Formula
C22H17F4N3O2
Formula Weight
431.38
MOL File
181629-93-6.mol
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N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE Property

Boiling point:
625.4±55.0 °C(Predicted)
Density 
1.398±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ~8 mg/mL, soluble
form 
solid
pka
9.72±0.70(Predicted)
color 
white
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1375
Product name
SB228357
Purity
≥99%(HPLC)
Packaging
10
Price
$153
Updated
2021/12/16
Tocris
Product number
1375
Product name
SB228357
Purity
≥99%(HPLC)
Packaging
50
Price
$643
Updated
2021/12/16
Usbiological
Product number
465900
Product name
SB 228357
Packaging
10mg
Price
$453
Updated
2021/12/16
TRC
Product number
S155035
Product name
SB228357
Packaging
25mg
Price
$305
Updated
2021/12/16
ChemScene
Product number
CS-0024682
Product name
SB228357
Purity
>99.0%
Packaging
5mg
Price
$360
Updated
2021/12/16
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N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE Chemical Properties,Usage,Production

Uses

SB 228357 is a SR-2C/SR-2B receptor antagonist. It is used in the treatment of irritable bowel syndrome (IBS).

Definition

ChEBI: SB 228357 is an indolyl carboxylic acid.

Biological Activity

5-HT 2C/2B receptor antagonist (pK i values are 7.0, 8.1 and 9.1 at 5-HT 2A , 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT 2C receptor function. Orally active in vivo .

in vivo

SB228357 (0-10 mg/kg; oral administration; for 90 minutes; male Sprague Dawley rats) treatment significantly reverses Haloperidol-induced catalepsy[2].

Animal Model:Male Sprague Dawley rats (200-250?g) injected with Haloperidol[2]
Dosage:0 mg/kg, 0.32 mg/kg, 1 mg/kg, 3.2 mg/kg, 10 mg/kg
Administration: Oral administration; for 90 minutes
Result:Significantly reversed Haloperidol-induced catalepsy.

IC 50

5-HT2A Receptor: 6.9 (pKi); 5-HT2C Receptor: 9 (pKi); 5-HT2B Receptor: 8 (pKi)

storage

Store at RT

N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE Suppliers

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181629-93-6, N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDERelated Search:

6-METHYL-2,3-DIHYDRO-1H-INDOLE 3-Fluoro-5-methylaniline N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE 5-AMINO-2-METHOXYBENZOTRIFLUORIDE 3-Pyridin-3-ylaniline alpha,alpha,alpha-Trifluoro-o-cresol 2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE 4-Amino-2,5-dimethylphenol 4-AMINO-2-(TRIFLUOROMETHYL)PHENOL 6-(Trifluoromethyl)indoline 2-(TRIFLUOROMETHYL)ANISOLE

  • N-[3-FLUORO-5-(3-PYRINDYL)PHENYL]-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
  • SB 228357
  • N-[3-Fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide
  • N-[3-fluoro-5-(3-pyridinyl)phenyl]-5-methoxy-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide
  • 1H-Indole-1-carboxamide, N-[3-fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-
  • SB-228357,SB228357
  • SB228357, 10 mM in DMSO
  • N-(3-Fluoro-5-(pyridin-3-yl)phenyl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide
  • 181629-93-6
  • C22H17F4N3O2