2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE
- Product Name
- 2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE
- CAS No.
- 775-00-8
- Chemical Name
- 2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE
- Synonyms
- RARECHEM AL BW 0217;4-Trifluoromethylphenethylamine; p-(Trifluoromethyl)phenethylamine;2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE;2-[4-(TRIFLUOROMETHYL)PHENYL]ETHANAMINE;Benzeneethanamine, 4-(trifluoromethyl)-;2-[4-(trifluoroMethyl)phenyl]ethan-1-aMine;2-[4-(trifluoromethyl)phenyl]ethanamine(SALTDATA: FREE)
- CBNumber
- CB6435749
- Molecular Formula
- C9H10F3N
- Formula Weight
- 189.18
- MOL File
- 775-00-8.mol
2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE Property
- Boiling point:
- 210℃
- Density
- 1.186
- refractive index
- 1.4620 to 1.4660
- Flash point:
- 86℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- clear liquid
- pka
- 9.49±0.10(Predicted)
- color
- Colorless to Light yellow to Light orange
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C9H10F3N/c10-9(11,12)8-3-1-7(2-4-8)5-6-13/h1-4H,5-6,13H2
- InChIKey
- HMFOBPNVAAAACP-UHFFFAOYSA-N
- SMILES
- C1(CCN)=CC=C(C(F)(F)F)C=C1
- CAS DataBase Reference
- 775-00-8(CAS DataBase Reference)
Safety
- RIDADR
- UN 2735 8/PG II
- HazardClass
- IRRITANT
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 2921490090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T3278
- Product name
- 2-(4-Trifluoromethylphenyl)ethylamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $66
- Updated
- 2025/07/31
- Product number
- T3278
- Product name
- 2-(4-Trifluoromethylphenyl)ethylamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $222
- Updated
- 2025/07/31
- Product number
- T896710
- Product name
- 2-(4-Trifluoromethyl-phenyl)-ethylamine
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 034256
- Product name
- 2-(4-Trifluoromethyl-phenyl)-ethylamine
- Packaging
- 500mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- J94884
- Product name
- 4-(Trifluoromethyl)phenethylamine
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE Chemical Properties,Usage,Production
Chemical Properties
2-(4-Trifluoromethylphenyl)ethylamine is colorless transparent to light yellow liquid at room temperature and pressure, slightly soluble in water, easily soluble in toluene and other organic solvents.
Uses
It is applied as an active pharmaceutical intermediate.
Synthesis
2338-75-2
775-00-8
The general procedure for the synthesis of 2-(4-trifluoromethylphenyl)ethylamine from p-trifluoromethylphenylacetonitrile was as follows: (4-trifluoromethylphenyl)acetonitrile (2 g, 10.81 mmol) was dissolved in methanol-ammonia solution (50 mL), which was subsequently added to a Parr hydrogenation reactor that had been charged with nickel Nguyenay (400 mg). The reaction mixture was stirred overnight under hydrogen pressure of 50 psi. The progress of the reaction was monitored by thin layer chromatography (TLC, the unfolding agent was a chloroform solution containing 10% methanol). Upon completion of the reaction, the mixture was filtered through a bed of diatomaceous earth and the filtrate was concentrated and dried under reduced pressure to afford the target product 2-(4-trifluoromethylphenyl)ethylamine (2 g, 97.89% yield). The product was analyzed by LCMS and the purity was 98.73%, m/z = 190.0 ([M+H]+).
References
[1] Patent: WO2012/35078, 2012, A1. Location in patent: Page/Page column 67
[2] Patent: US2014/45872, 2014, A1. Location in patent: Paragraph 0403
[3] Patent: WO2004/82682, 2004, A1. Location in patent: Page 44-45
[4] Patent: WO2003/93231, 2003, A2. Location in patent: Page/Page column 48
[5] Patent: WO2005/80371, 2005, A1. Location in patent: Page/Page column 49
2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE manufacturers
- Product
- 2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE 775-00-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-09