ChemicalBook > CAS DataBase List > 2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE

2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE

Product Name: 2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE
CAS No.: 775-00-8
Chemical Name: 2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE
Synonyms: RARECHEM AL BW 0217;4-Trifluoromethylphenethylamine; p-(Trifluoromethyl)phenethylamine;2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE;2-[4-(TRIFLUOROMETHYL)PHENYL]ETHANAMINE;Benzeneethanamine, 4-(trifluoromethyl)-;2-[4-(trifluoroMethyl)phenyl]ethan-1-aMine;2-[4-(trifluoromethyl)phenyl]ethanamine(SALTDATA: FREE)
CBNumber: CB6435749
Molecular Formula: C9H10F3N
Formula Weight: 189.18
MOL File: 775-00-8.mol

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2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE Property

Boiling point:: 210℃
Density: 1.186
refractive index: 1.4620 to 1.4660
Flash point:: 86℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: clear liquid
pka: 9.49±0.10(Predicted)
color: Colorless to Light yellow to Light orange
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C9H10F3N/c10-9(11,12)8-3-1-7(2-4-8)5-6-13/h1-4H,5-6,13H2
InChIKey: HMFOBPNVAAAACP-UHFFFAOYSA-N
SMILES: C1(CCN)=CC=C(C(F)(F)F)C=C1
CAS DataBase Reference: 775-00-8(CAS DataBase Reference)

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Safety

RIDADR: UN 2735 8/PG II
HazardClass: IRRITANT
HazardClass: 8
PackingGroup: II
HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T3278
Product name: 2-(4-Trifluoromethylphenyl)ethylamine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $66
Updated: 2025/07/31

TCI Chemical

Product number: T3278
Product name: 2-(4-Trifluoromethylphenyl)ethylamine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $222
Updated: 2025/07/31

TRC

Product number: T896710
Product name: 2-(4-Trifluoromethyl-phenyl)-ethylamine
Packaging: 500mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3830-3-57
Product name: 2-[4-(Trifluoromethyl)phenyl]ethan-1-amine
Purity: 98%
Packaging: 5G
Price: $64
Updated: 2021/12/16

AK Scientific

Product number: W8409
Product name: 4-(Trifluoromethyl)phenethylamine
Packaging: 25g
Price: $174
Updated: 2021/12/16

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2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE Chemical Properties,Usage,Production

Chemical Properties

2-(4-Trifluoromethylphenyl)ethylamine is colorless transparent to light yellow liquid at room temperature and pressure, slightly soluble in water, easily soluble in toluene and other organic solvents.

Uses

It is applied as an active pharmaceutical intermediate.

Synthesis

2338-75-2

775-00-8

The general procedure for the synthesis of 2-(4-trifluoromethylphenyl)ethylamine from p-trifluoromethylphenylacetonitrile was as follows: (4-trifluoromethylphenyl)acetonitrile (2 g, 10.81 mmol) was dissolved in methanol-ammonia solution (50 mL), which was subsequently added to a Parr hydrogenation reactor that had been charged with nickel Nguyenay (400 mg). The reaction mixture was stirred overnight under hydrogen pressure of 50 psi. The progress of the reaction was monitored by thin layer chromatography (TLC, the unfolding agent was a chloroform solution containing 10% methanol). Upon completion of the reaction, the mixture was filtered through a bed of diatomaceous earth and the filtrate was concentrated and dried under reduced pressure to afford the target product 2-(4-trifluoromethylphenyl)ethylamine (2 g, 97.89% yield). The product was analyzed by LCMS and the purity was 98.73%, m/z = 190.0 ([M+H]+).

References

[1] Patent: WO2012/35078, 2012, A1. Location in patent: Page/Page column 67
[2] Patent: US2014/45872, 2014, A1. Location in patent: Paragraph 0403
[3] Patent: WO2004/82682, 2004, A1. Location in patent: Page 44-45
[4] Patent: WO2003/93231, 2003, A2. Location in patent: Page/Page column 48
[5] Patent: WO2005/80371, 2005, A1. Location in patent: Page/Page column 49

2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE manufacturers

Career Henan Chemical Co

Product: 2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE 775-00-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-09

775-00-8, 2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINERelated Search:

Benzeneethanamine, 4-(trifluoromethyl)-

RARECHEM AL BW 0217

2-[4-(TRIFLUOROMETHYL)PHENYL]ETHANAMINE

2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE

4-Trifluoromethylphenethylamine

2-[4-(trifluoromethyl)phenyl]ethanamine(SALTDATA: FREE)

2-[4-(trifluoroMethyl)phenyl]ethan-1-aMine

p-(Trifluoromethyl)phenethylamine

775-00-8

75-00-8

Fluorine series

Halogenated Heterocycles ,Isoquinolines ,Quinolines ,Quinazolines ,Quinaldines

Benzene series

Aminomethyl's

Phenyls & Phenyl-Het