4-(Trifluoromethyl)-L-phenylalanine

Product Name: 4-(Trifluoromethyl)-L-phenylalanine
CAS No.: 114926-38-4
Chemical Name: 4-(Trifluoromethyl)-L-phenylalanine
Synonyms: H-PHE(4-CF 3)-OH;RARECHEM BK PT 0139;L-4-TRIFLUOROMETHYLPHE;L-4-Trifluoromethyl-phe-OH;H-L-PHE(4-TRIFLUOROMETHYL)-OH;L-4-TRIFLUOROMETHYLPHENYLALANINE;p-Trifluoromethyl-L-phenylalanine;4-(TRIFLUOROMETHYL)-L-PHENYLALANINE;L-Phenylalanine,4-(trifluoroMethyl)-;3-(4-Trifluoromethylphenyl)-L-alanine
CBNumber: CB3193381
Molecular Formula: C10H10F3NO2
Formula Weight: 233.19
MOL File: 114926-38-4.mol

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4-(Trifluoromethyl)-L-phenylalanine Property

Boiling point:: 311.5±42.0 °C(Predicted)
Density: 1.364±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
form: solid
pka: 2.15±0.10(Predicted)
color: White to yellow
optical activity: -16.23°(C=0.01g/ml MEOH)
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C10H10F3NO2/c11-10(12,13)7-3-1-6(2-4-7)5-8(14)9(15)16/h1-4,8H,5,14H2,(H,15,16)/t8-/m0/s1
InChIKey: CRFFPDBJLGAGQL-QMMMGPOBSA-N
SMILES: C(O)(=O)[C@H](CC1=CC=C(C(F)(F)F)C=C1)N
CAS DataBase Reference: 114926-38-4(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: T897038
Product name: 4-(Trifluoromethyl)-L-phenylalanine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 241151
Product name: p-Trifluoromethyl-L-phenylalanine
Packaging: 250mg
Price: $233
Updated: 2021/12/16

ChemScene

Product number: CS-W014678
Product name: 4-(Trifluoromethyl)-L-phenylalanine
Purity: >97.0%
Packaging: 1g
Price: $53
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4857-3-14
Product name: 4-(Trifluoromethyl)-L-phenylalanine
Purity: 98%
Packaging: 250mg
Price: $65
Updated: 2021/12/16

Chem-Impex

Product number: 07388
Product name: -Trifluoromethyl-L-phenylalanine
Purity: ≥ 99% (HPLC)
Packaging: 250MG
Price: $65
Updated: 2021/12/16

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4-(Trifluoromethyl)-L-phenylalanine Chemical Properties,Usage,Production

Uses

4-fluoro-l-phenylalanine (fF), or 4-trifluoromethyl-l-phenylalanine were introduced inside the chain of peptides to enhances their antimicrobial activity..

Synthesis

114872-59-2

82337-58-4

3832-75-5

Step 2: Diethyl 2-acetamido-2-(4-(trifluoromethyl)benzyl)malonate (LXII, theoretical amount 0.125 mol) was dissolved in acetone (400 mL) and 2 M aqueous NaOH solution (400 mL) was added. The reaction mixture was refluxed overnight and subsequently concentrated under reduced pressure to remove the solvent. The residue was dissolved in water and washed with hexane (3 x 400 mL). The aqueous phase was adjusted to pH=1 with acid and the precipitate was collected by filtration to afford 2-acetamido-3-(4-(trifluoromethyl)phenyl)propionic acid (LXIII) as a white solid (25.8 g, 93.7 mmol, 75% overall yield in two steps).

References

[1] Patent: WO2012/109164, 2012, A1. Location in patent: Page/Page column 53-54

4-(Trifluoromethyl)-L-phenylalanine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(Trifluoromethyl)-L-phenylalanine Suppliers

China 112 Germany 3 India 1 Japan 2 Switzerland 1 United Kingdom 3 United States 20 Global 142

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View Lastest Price from 4-(Trifluoromethyl)-L-phenylalanine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-(Trifluoromethyl)phenylalanine 114926-38-4
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-09-08

Career Henan Chemical Co

Product: 4-(Trifluoromethyl)-L-phenylalanine 114926-38-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 354
Release date: 2019-09-01

114926-38-4, 4-(Trifluoromethyl)-L-phenylalanineRelated Search:

Propionic acid N-(tert-Butoxycarbonyl)-L-phenylalanine Glycine 6-Aminocaproic acid 3-(Trifluoromethyl)benzaldehyde 3-（trifluoromethyl) Cinnamaldehyde Phenyl salicylate 4-Nitro-3-phenyl-L-alanine Diphenyl ether ALTRENOGEST (Trifluoromethyl)trimethylsilane PHENYL VALERATE Trifluoromethanesulfonic anhydride Phenprobamate D-4-TRIFLUOROMETHYLPHENYLALANINE L-Phenylalanine PHENYL RESIN Fluorenylmethoxycarbonyl-L-4-trifluoromethylphenylalanine,FMOC-L-4-TRIFLUOROMETHYLPHENYLALANINE,FMOC-4-(Trifluoromethyl)-L-phenylalanine

L-4-TRIFLUOROMETHYLPHE

4-(TRIFLUOROMETHYL)-L-PHENYLALANINE

L-4-TRIFLUOROMETHYLPHENYLALANINE

L-3-[4-(TRIFLUOROMETHYL)PHENYL]ALANINE

H-L-PHE(4-TRIFLUOROMETHYL)-OH

H-PHE(4-CF 3)-OH

(S)-2-AMINO-3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID

RARECHEM BK PT 0139

(2S)-2-amino-3-[4-(trifluoromethyl)phenyl]propanoic acid

3-(4-Trifluoromethylphenyl)-L-alanine

L-4-Trifluoromethyl-phe-OH

REF DUPL: 4-Trifluoromethyl-L-Phenylalanine

L-Phenylalanine,4-(trifluoroMethyl)-

p-Trifluoromethyl-L-phenylalanine

4-(Trifluoromethyl)-L-phenylalanine, >=98%

4-Trifluoromethyl-L-phenylalanine,95%

4-(Trifluoromethyl)-L-phenylalanine USP/EP/BP

114926-38-4

Phenylalanine Derivatives

Peptide Synthesis

Specialty Synthesis

Unnatural Amino Acid Derivatives

a-amino

Amino Acids