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4-Nitro-3-phenyl-L-alanine

Product Name
4-Nitro-3-phenyl-L-alanine
CAS No.
949-99-5
Chemical Name
4-Nitro-3-phenyl-L-alanine
Synonyms
4-NO2-Phe;L-4-NITROPHE;L-Phe(4-NO2);(P-NO2)PHE-OH;L-4-NO2-Phe-OH;L-Phe(4-NO2)-OH;H-PHE(4-NO2)-OH;H-P-NITRO-PHE-OH;H-L-Phe(4-NO2)-OH;4-Nitro-L<
CBNumber
CB7382549
Molecular Formula
C9H10N2O4
Formula Weight
210.19
MOL File
949-99-5.mol
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4-Nitro-3-phenyl-L-alanine Property

Melting point:
236-239°C (dec.)
Boiling point:
414.1±35.0 °C(Predicted)
Density 
1.408±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
2.12±0.10(Predicted)
Appearance
Off-white to light brown Solid
InChI
InChI=1S/C9H10N2O4/c10-8(9(12)13)5-6-1-3-7(4-2-6)11(14)15/h1-4,8H,5,10H2,(H,12,13)/t8-/m0/s1
InChIKey
GTVVZTAFGPQSPC-QMMMGPOBSA-N
SMILES
C(O)(=O)[C@H](CC1=CC=C([N+]([O-])=O)C=C1)N
CAS DataBase Reference
949-99-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,C,F
Risk Statements 
36/37/38-22-34-11
Safety Statements 
26-36/37/39-22-45-16
RIDADR 
2811
RTECS 
AY7400000
Hazard Note 
Harmful
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R267678
Product name
2-AMINO-3-(4-NITRO-PHENYL)-PROPIONIC ACID
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$30.7
Updated
2025/07/31
Sigma-Aldrich
Product number
R267678
Product name
2-AMINO-3-(4-NITRO-PHENYL)-PROPIONIC ACID
Purity
AldrichCPR
Packaging
50MG
Price
$29.8
Updated
2024/03/01
TCI Chemical
Product number
N0682
Product name
4-Nitro-L-phenylalanine Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$20
Updated
2025/07/31
TCI Chemical
Product number
N0682
Product name
4-Nitro-L-phenylalanine Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$37
Updated
2025/07/31
TRC
Product number
N496630
Product name
4-Nitro-L-phenylalanine
Packaging
25g
Price
$85
Updated
2021/12/16
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4-Nitro-3-phenyl-L-alanine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

4-Nitro-L-phenylalanine is used in the studies on the rational manipulation of protein structures for the expansion of the genetic code with non natural amino acids into protein via in vitro translation.

Synthesis

63-91-2

949-99-5

General steps: 1. dissolve L-phenylalanine (16.5 g, 100 mmol) in 85% sulfuric acid (50 ml). 2. under stirring conditions, add slowly and dropwise a pre-prepared and cooled to room temperature acid mixture of concentrated nitric acid and concentrated sulfuric acid (1.4:1.1 by volume). 3. Stir the reaction mixture continuously for 5 hours at room temperature. 4. The pH of the reaction solution was adjusted to 2-3 using 40% sodium hydroxide solution, at which time a large amount of precipitate was formed. 5. Collect the precipitate by filtration and wash with deionized water until the filtrate is neutral. 6. 6. Dry the precipitate under reduced pressure to obtain 4-nitro-L-phenylalanine (20 g, yield 95.2%).

References

[1] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 8, p. 3118 - 3125
[2] Patent: US2009/247470, 2009, A1. Location in patent: Page/Page column 12
[3] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 18, p. 5352 - 5360
[4] Russian Journal of Organic Chemistry, 2016, vol. 52, # 11, p. 1681 - 1685
[5] Zh. Org. Khim., 2016, vol. 52, # 11, p. 1686 - 1690,5

4-Nitro-3-phenyl-L-alanine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Nitro-3-phenyl-L-alanine Suppliers

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View Lastest Price from 4-Nitro-3-phenyl-L-alanine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-Nitro-3-phenyl-L-alanine 949-99-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Honest Joy Holdings Limited
Product
4-Nitro-L-phenylalanine 949-99-5
Price
US $0.00/KG
Min. Order
1KG
Purity
97.9%
Supply Ability
100 tons
Release date
2022-02-21
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Nitro-3-phenyl-L-alanine 949-99-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

949-99-5, 4-Nitro-3-phenyl-L-alanineRelated Search:

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