A-18-F-NH2
- Product Name
- A-18-F-NH2
- CAS No.
- 99588-52-0
- Chemical Name
- A-18-F-NH2
- Synonyms
- A18Famide;A-18-F-NH2;PubChem ID: 16131005;Morphine Modulating Neuropeptide;ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE-NH2;H-ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE-NH2;ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE AMIDE;A-18-F-NH2;H-ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE-NH2;L-Phenylalaninamide, L-alanylglycyl-L-α-glutamylglycyl-L-leucyl-L-seryl-L-seryl-L-prolyl-L-phenylalanyl-L-tryptophyl-L-seryl-L-leucyl-L-alanyl-L-alanyl-L-prolyl-L-glutaminyl-L-arginyl-
- CBNumber
- CB1682771
- Molecular Formula
- C89H130N24O24
- Formula Weight
- 1920.13
- MOL File
- 99588-52-0.mol
A-18-F-NH2 Property
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- -15°C
- pka
- 4.43±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- M4675-01A
- Product name
- Morphine Modulating Neuropeptide
- Packaging
- 1mg
- Price
- $531
- Updated
- 2021/12/16
- Product number
- M4675-01
- Product name
- Morphine Modulating Neuropeptide
- Packaging
- 1mg
- Price
- $531
- Updated
- 2021/12/16
- Product number
- PEP0009156
- Product name
- A-18-F-NH2
- Purity
- 95.00%
- Packaging
- 0.5MG
- Price
- $599.5
- Updated
- 2021/12/16
- Product number
- PEP0009156
- Product name
- A-18-F-NH2
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $664.13
- Updated
- 2021/12/16
- Product number
- orb71317
- Product name
- Morphine Modulating Neuro peptide
- Purity
- Greater than 85% affinity purified
- Packaging
- 5mg
- Price
- $425
- Updated
- 2021/12/16
A-18-F-NH2 Chemical Properties,Usage,Production
Uses
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects[1][2].
in vivo
Neuropeptide AF (cattle) (0.25 μg/2 μL; i.c.v.; 30 min prior to the tests) decreases the immobility time and increases the climbing and swimming times in modified mouse forced swimming test (mFST)[2].
| Animal Model: | Male CFLP mice (25-28 g)[2] |
| Dosage: | 0.25 μg/2 μL |
| Administration: | i.c.v.; 30 min prior to the tests |
| Result: | Decreased the immobility time and increased the climbing and swimming times. |
References
[1] Nada Abdellah, et al. Neuropeptide AF Induces Piecemeal Degranulation in Murine Mucosal Mast Cells: A New Mediator in Neuro-Immune Communication in the Intestinal Lamina Propria? Anat Rec (Hoboken). 2018 Jun;301(6):1103-1114. DOI:10.1002/ar.23780
[2] Miklós Palotai, et al. Neuropeptide AF induces anxiety-like and antidepressant-like behavior in mice. Behav Brain Res. 2014 Nov 1;274:264-9. DOI:10.1016/j.bbr.2014.08.007
A-18-F-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
A-18-F-NH2 Suppliers
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