BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE

Product Name: BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE
CAS No.: 116673-45-1
Chemical Name: BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE
Synonyms: TRANS-BTP DIOXOLANE;BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE;(2R,4R)-rel-2,4-Bis(3,4,5-triMethoxyphenyl)-1,3-dioxolane;TRANS-(+/-)-2,4-BIS(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE;(+/-) TRANS-2,5-BIS(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE;1,3-Dioxolane, 2,4-bis(3,4,5-trimethoxyphenyl)-, (2R,4R)-rel-
CBNumber: CB1683314
Molecular Formula: C21H26O8
Formula Weight: 406.43
MOL File: 116673-45-1.mol

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BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE Property

Boiling point:: 508.3±50.0 °C(Predicted)
Density: 1.184±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤35mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide
form: White to off-white solid.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J67356
Product name: (±)-trans-2,5-Bis-(3,4,5-trimethoxyphenyl)-1,3-dioxolane
Packaging: 1mg
Price: $56.4
Updated: 2021/12/16

Alfa Aesar

Product number: J67356
Product name: (±)-trans-2,5-Bis-(3,4,5-trimethoxyphenyl)-1,3-dioxolane
Packaging: 5mg
Price: $220
Updated: 2021/12/16

Cayman Chemical

Product number: 60950
Product name: (±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 60950
Product name: (±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane
Purity: ≥98%
Packaging: 5mg
Price: $182
Updated: 2024/03/01

Cayman Chemical

Product number: 60950
Product name: (±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane
Purity: ≥98%
Packaging: 10mg
Price: $322
Updated: 2024/03/01

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BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE Chemical Properties,Usage,Production

Uses

A potent and selective platlet activating factor

Biological Activity

(±)trans-2,5-bis-(3,4,5-trimethoxyphenyl)-1,3-dioxolane, also known as trans-btp dioxolane, is a paf receptor antagonist [1].platelet activating factor (paf), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. paf also stimulates the production of active oxygen species by human monocyte - derived macrophages. paf play important roles in a variety of pathophysiological states including acute allergy, inflammation, asthma, gastrointestinal ulceration, and toxic shock [1].(±)trans-2,5-bis-(3,4,5-trimethoxyphenyl)-1,3-dioxolane is a paf receptor antagonist. in the rabbit washed platelet assay, (±)trans-2,5-bis-(3,4,5-trimethoxyphenyl)-1,3-dioxolane showed good competitive paf antagonism with ki value of 0.3 μm, whereas the cis-isomer was much less active.

References

[1]. corey, e.j.,chen, c.p., and parry, m.j. dual binding modes to the receptor for platelet activating factor (paf) of anti-paf trans-2,5-diarylfurans. tetrahedron letters 29, 2899-2902 (1988).

BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE Preparation Products And Raw materials

Raw materials

Preparation Products

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116673-45-1, BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANERelated Search:

3,5,9-Trioxa-4-phosphapentacosan-1-aminium,7-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-10-oxo-,innersalt,4-oxide,(S] β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine hydrate P-ANISALDEHYDE DIMETHYL ACETAL VANILLIN PROPYLENE GLYCOL ACETAL 2-(3,4-Dimethoxyphenyl)ethanol (S)-(+)-2-METHOXY-2-PHENYLETHANOL 3,5-DIMETHOXY-4-HYDROXYPHENYLMETHYL CARBINOL DIVERATRYL ETHER BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE 2-(3,5-DIMETHOXYPHENYL)ETHANOL 2-(3,4,5-TRIMETHOXYPHENYL)ETHANOL (1R)-1-(3-METHOXYPHENYL)ETHANOL 1-(3,4-DIMETHOXYPHENYL)ETHANOL 3,4,5-TRIMETHOXYBENZALDEHYDE DIMETHYL ACETAL 3,4,5-TRIMETHOXYPHENYLMETHYL CARBINOL (+/-) CIS-2,5-BIS(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE 2,5-bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane

BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE

TRANS-BTP DIOXOLANE

(+/-) TRANS-2,5-BIS(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE

TRANS-(+/-)-2,4-BIS(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE

(2R,4R)-rel-2,4-Bis(3,4,5-triMethoxyphenyl)-1,3-dioxolane

1,3-Dioxolane, 2,4-bis(3,4,5-trimethoxyphenyl)-, (2R,4R)-rel-

116673-45-1

Aromatics Compounds

Aromatics

Heterocycles