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ENDOMORPHIN-1

Product Name
ENDOMORPHIN-1
CAS No.
189388-22-5
Chemical Name
ENDOMORPHIN-1
Synonyms
YPWF-NH2;ENDOMORPHIN-1;TYR-PRO-TRP-PHE-NH2;H-TYR-PRO-TRP-PHE-NH2;Endomorphin-1 Acetate Salt;Endomorphin 1, Endomorphin 1;ENDOMORPHIN-1 (HUMAN, BOVINE);L-Tyrosyl-L-prolyl-L-tryptophyl-L-phenylalaninamide;L-Phenylalaninamide,L-tyrosyl-L-prolyl-L-tryptophyl-;(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-[[(1S)-1-carbamoyl-2-phenyl-ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]pyrrolidine-2-carboxamide
CBNumber
CB1684104
Molecular Formula
C34H38N6O5
Formula Weight
610.7
MOL File
189388-22-5.mol
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ENDOMORPHIN-1 Property

Melting point:
144-146℃
Boiling point:
1052.8±65.0 °C(Predicted)
Density 
1.343±0.06 g/cm3(Predicted)
RTECS 
SQ7316800
storage temp. 
−20°C
solubility 
≥14.9 mg/mL in H2O; ≥30.55 mg/mL in DMSO; ≥47 mg/mL in EtOH
pka
9.86±0.15(Predicted)
form 
Solid
color 
White to off-white
Water Solubility 
Soluble in water
CAS DataBase Reference
189388-22-5(CAS DataBase Reference)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J66775
Product name
Endomorphin-1
Packaging
5mg
Price
$80.4
Updated
2021/12/16
Alfa Aesar
Product number
J66775
Product name
Endomorphin-1
Packaging
25mg
Price
$308
Updated
2021/12/16
Tocris
Product number
1055
Product name
Endomorphin-1
Packaging
5
Price
$127
Updated
2021/12/16
Usbiological
Product number
448211
Product name
Endomorphin 1
Packaging
5mg
Price
$403
Updated
2021/12/16
Usbiological
Product number
E2291-02
Product name
Endomorphin 1
Packaging
50ul
Price
$410
Updated
2021/12/16
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ENDOMORPHIN-1 Chemical Properties,Usage,Production

Definition

ChEBI: L-Phenylalaninamide, L-tyrosyl-L-prolyl-L-tryptophyl- is an oligopeptide.

Biological Activity

endomorphins are two endogenous opioid peptides. endomorphin-1 (tyr-pro-trp-phe-nh2) and endomorphin-2 (tyr-pro-phe-phe-nh2) are tetrapeptides with the highest known affinity and specificity for the μ opioid receptor. endomorphin-1 is located in the nucleus of the solitary tract, the periventricular hypothalamus, and the dorsomedial hypothalamus, where it is found within histaminergic neurons and may regulate sedative and arousal behaviors(1). it is assumed that endomorphins are the cleavage products of a larger precursor, but this polypeptide or protein has not yet been identified. perikarya expressing em2-like immunoreactivity were present in the posterior hypothalamus, whereas those expressing em1-like immunoreactivity were present in both the posterior hypothalamus and the nucleus of the solitary tract (nts). em1-like immunoreactivity was more widely and densely distributed throughout the brain than was em2-like immunoreactivity, whereas em2-like immunoreactivity was more prevalent in the spinal cord than was em1-like immunoreactivity. endomorphins participate in modulating nociceptive and autonomic nervous system processes and responsiveness to stress.figure1 formula of endomorphin-1figure 2 the endomorphin system and its evolving neurophysiological role

in vitro

Endomorphin 1 (EM-1) is an endogenous opioid peptide and one of the two Endomorphins. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with Endomorphin 2 (EM-2 ).

target

Ki: 20-30 nM (kappa 3 opioid receptor)

storage

-20°C (desiccate)

References

1. Greco, MA; Fuller, PM; Jhou, TC; Martin-Schild, S; Zadina, JE; Hu, Z; Shiromani, P; Lu, J (2008). "Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus". Brain Research 1245: 96–107.

ENDOMORPHIN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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ENDOMORPHIN-1 Suppliers

China 86 France 1 Germany 6 Japan 1 Switzerland 1 United Kingdom 3 United States 18 Global 116
MOLEKULA Ltd.
Tel
--
Fax
--
Email
kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
Advantage
66
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
VWR International
Tel
--
Fax
--
Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82
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View Lastest Price from ENDOMORPHIN-1 manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd
Product
ENDOMORPHIN-1 189388-22-5
Price
US $0.00/gram
Min. Order
1gram
Purity
99% min
Supply Ability
20 tons
Release date
2023-07-18
Career Henan Chemical Co
Product
ENDOMORPHIN-1 189388-22-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-13

189388-22-5, ENDOMORPHIN-1Related Search:

ANTI-ENDOMORPHIN-1 AND -2 ENDOMORPHIN-2,ENDOMORPHIN-2 (HUMAN, BOVINE) ANTI-ENDOMORPHIN-1 ENDOMORPHIN-1,RABBITANTI-HUMAN,EIAKIT ([125I]-TYR)-ENDOMORPHIN-2 ENDOMORPHIN-2,RABBITANTI-,EIAKIT ENDOMORPHIN 1, [TYR-3,5-3H] ANTI-ENDOMORPHIN ENDOMORPHIN-2 (HUMAN, BOVINE) ACOH H2O ENDOMORPHIN 2, [TYR-3,5-3H] prolyl(2)-endomorphin-2 ANTI-ENDOMORPHIN-2 BIOTIN-BETA-ENDOMORPHIN, HUMAN ENDOMORPHIN-1 (HUMAN, BOVINE) ACOH H2O ENDOMORPHIN-1 H-TYR-PRO-TRP-GLY-NH2

  • L-Tyrosyl-L-prolyl-L-tryptophyl-L-phenylalaninamide
  • H-TYR-PRO-TRP-PHE-NH2
  • ENDOMORPHIN-1
  • ENDOMORPHIN-1 (HUMAN, BOVINE)
  • TYR-PRO-TRP-PHE-NH2
  • YPWF-NH2
  • L-Phenylalaninamide,L-tyrosyl-L-prolyl-L-tryptophyl-
  • Endomorphin 1, Endomorphin 1
  • (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-[[(1S)-1-carbamoyl-2-phenyl-ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]pyrrolidine-2-carboxamide
  • (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
  • Endomorphin-1 Acetate Salt
  • 189388-22-5
  • C34H38N6O5
  • Biochemicals and Reagents
  • BioChemical
  • Amino Acids and Peptides
  • Peptides
  • Opioid Peptides
  • Other Opioid Peptides
  • SignalTransduction
  • Other Opioid Peptides
  • Other Opioid PeptidesPeptides for Cell Biology
  • Opioid receptor and opioid-like receptor
  • Peptide
  • Neuropeptides
  • Opioid Peptides