4-IODO-6-PHENYLPYRIMIDINE
- Product Name
- 4-IODO-6-PHENYLPYRIMIDINE
- CAS No.
- 41270-96-6
- Chemical Name
- 4-IODO-6-PHENYLPYRIMIDINE
- Synonyms
- 4-IPP;4-IPP, 10 mM in DMSO;MIF Antagonist III, 4-IPP;4-IODO-6-PHENYLPYRIMIDINE;Pyrimidine, 4-iodo-6-phenyl-;4-IPP (4-Iodo-6-phenylpyrimidine);MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem;Inhibitor,osteoclastogenesis,4IPP,MIF,4-IPP,inhibit,4 IPP,RANKL,osteoblast
- CBNumber
- CB1686643
- Molecular Formula
- C10H7IN2
- Formula Weight
- 282.08
- MOL File
- Mol file
4-IODO-6-PHENYLPYRIMIDINE Property
- Boiling point:
- 380.2±30.0 °C(Predicted)
- Density
- 1.728±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble10mg/mL (clear solution, warmed)
- form
- powder
- pka
- -0.54±0.17(Predicted)
- color
- white to beige
- InChIKey
- ZTCJXHNJVLUUMR-UHFFFAOYSA-N
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0472
- Product name
- 4-IPP
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $158
- Updated
- 2024/03/01
- Product number
- 475846
- Product name
- MIF Antagonist III, 4-IPP
- Packaging
- 10mg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- SML0472
- Product name
- 4-IPP
- Purity
- ≥97% (HPLC)
- Packaging
- 25mg
- Price
- $631
- Updated
- 2024/03/01
- Product number
- 3429
- Product name
- 4-IPP
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $688
- Updated
- 2021/12/16
- Product number
- 3429
- Product name
- 4-IPP
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $163
- Updated
- 2021/12/16
4-IODO-6-PHENYLPYRIMIDINE Chemical Properties,Usage,Production
Uses
4-IPP has been used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for in vitro migration assay.
Definition
ChEBI: 4-iodo-6-phenylpyrimidine is a member of the class of pyrimidines carrying iodo and phenyl substituents at positions 4 and 6 respectively. It has a role as a macrophage migration inhibitory factor inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of pyrimidines, a biaryl and an organoiodine compound.
Biological Activity
Inhibitor of macrophage migration inhibitor factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo . Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro .
Biochem/physiol Actions
4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas.
storage
Store at +4°C
4-IODO-6-PHENYLPYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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