4-IODO-6-PHENYLPYRIMIDINE

Product Name: 4-IODO-6-PHENYLPYRIMIDINE
CAS No.: 41270-96-6
Chemical Name: 4-IODO-6-PHENYLPYRIMIDINE
Synonyms: 4-IPP;MIF Antagonist III, 4-IPP;4-IODO-6-PHENYLPYRIMIDINE;Pyrimidine, 4-iodo-6-phenyl-;4-IPP (4-Iodo-6-phenylpyrimidine);MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem;Inhibitor,osteoclastogenesis,4IPP,MIF,4-IPP,inhibit,4 IPP,RANKL,osteoblast
CBNumber: CB1686643
Molecular Formula: C10H7IN2
Formula Weight: 282.08
MOL File: Mol file

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4-IODO-6-PHENYLPYRIMIDINE Property

Boiling point:: 380.2±30.0 °C(Predicted)
Density: 1.728±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble10mg/mL (clear solution, warmed)
form: powder
pka: -0.54±0.17(Predicted)
color: white to beige
InChIKey: ZTCJXHNJVLUUMR-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0472
Product name: 4-IPP
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $158
Updated: 2024/03/01

Sigma-Aldrich

Product number: 475846
Product name: MIF Antagonist III, 4-IPP
Packaging: 10mg
Price: $159
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0472
Product name: 4-IPP
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $631
Updated: 2024/03/01

Tocris

Product number: 3429
Product name: 4-IPP
Purity: ≥98%(HPLC)
Packaging: 50
Price: $688
Updated: 2021/12/16

Tocris

Product number: 3429
Product name: 4-IPP
Purity: ≥98%(HPLC)
Packaging: 10
Price: $163
Updated: 2021/12/16

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4-IODO-6-PHENYLPYRIMIDINE Chemical Properties,Usage,Production

Uses

4-IPP has been used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for in vitro migration assay.

Definition

ChEBI: 4-iodo-6-phenylpyrimidine is a member of the class of pyrimidines carrying iodo and phenyl substituents at positions 4 and 6 respectively. It has a role as a macrophage migration inhibitory factor inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of pyrimidines, a biaryl and an organoiodine compound.

Biological Activity

Inhibitor of macrophage migration inhibitor factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo . Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro .

Biochem/physiol Actions

4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas.

storage

Store at +4°C

4-IODO-6-PHENYLPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-IODO-6-PHENYLPYRIMIDINE Suppliers

China 43 The Netherlands 1 United Kingdom 1 United States 7 USA 1 Global 53

3B Pharmachem (Wuhan) International Co.,Ltd.

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Sigma-Aldrich

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DC Chemicals

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41270-96-6, 4-IODO-6-PHENYLPYRIMIDINERelated Search:

4-IODO-6-PHENYLPYRIMIDINE

4-IPP

MIF Antagonist III, 4-IPP

MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem

Pyrimidine, 4-iodo-6-phenyl-

4-IPP (4-Iodo-6-phenylpyrimidine)

Inhibitor,osteoclastogenesis,4IPP,MIF,4-IPP,inhibit,4 IPP,RANKL,osteoblast

41270-96-6