NAPHTHOFLUORESCEIN

Product Name: NAPHTHOFLUORESCEIN
CAS No.: 61419-02-1
Chemical Name: NAPHTHOFLUORESCEIN
Synonyms: Naphthafluorescein;NAPHTHOFLUORESCEIN;NAPHTHOFLUORESCEIN, FOR FLUORESCENCE;NAPHTHOFLUORESCEIN FOR FLUORESCENCE 95+%;Spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one,3,11-dihydroxy-
CBNumber: CB1689770
Molecular Formula: C28H16O5
Formula Weight: 432.42
MOL File: 61419-02-1.mol

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NAPHTHOFLUORESCEIN Property

Melting point:: 189 °C (dec.)(lit.)
Boiling point:: 755.5±60.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: soluble
form: A crystalline solid
pka: 8.82±0.20(Predicted)
color: Purple to purplish red
BRN: 61335
InChI: 1S/C28H16O5/c29-17-7-9-19-15(13-17)5-11-23-25(19)32-26-20-10-8-18(30)14-16(20)6-12-24(26)28(23)22-4-2-1-3-21(22)27(31)33-28/h1-14,29-30H
InChIKey: IXQIUDNVFVTQLJ-UHFFFAOYSA-N
SMILES: Oc1ccc2c3Oc4c(ccc5cc(O)ccc45)C6(OC(=O)c7ccccc67)c3ccc2c1
EPA Substance Registry System: Spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one, 3,11-dihydroxy- (61419-02-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 8-10
TSCA: TSCA listed
HS Code: 29329990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 70420
Product name: Naphthofluorescein
Purity: suitable for fluorescence
Packaging: 100mg
Price: $88.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 70420
Product name: Naphthofluorescein
Purity: suitable for fluorescence
Packaging: 500mg
Price: $322
Updated: 2025/07/31

Cayman Chemical

Product number: 13055
Product name: Naphthofluorescein
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 13055
Product name: Naphthofluorescein
Purity: ≥98%
Packaging: 10mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 13055
Product name: Naphthofluorescein
Purity: ≥98%
Packaging: 50mg
Price: $214
Updated: 2024/03/01

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NAPHTHOFLUORESCEIN Chemical Properties,Usage,Production

Uses

Naphthofluorescein is a furin inhibitor.

Uses

Naphtofluorescein is a pH-sensitive fluorescent probe, also used for preparation of labels and enzyme substrates.

Definition

ChEBI: Naphthofluorescein is a member of xanthenes.

in vivo

Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks)does not show weight loss or apparent histological abnormalities in the lung, liver, and kidney, or cause cause severe adverse effects for at least 2 weeks in mice^[1].
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks) strikingly suppresses the tumour growth of subcutaneously injected E0771 cells and significantly attenuates tumour growth of MDA-MB-231 and AsPC-1 cells in immunodeficient mice. In turn, naphthofluorescein does not attenuate tumour growth of FIH-1-depleted MDA-MB-231 cells^[1].
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks) suppresses tumour growth in human cancer cells in an FIH-1-dependent manner^[1].

Animal Model:	Male C57BL/6J mice (8 weeks)^[1]
Dosage:	100 mg/kg
Administration:	i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks
Result:	Neither showed weight loss or apparent histological abnormalities in the lung, liver, and kidney, or caused cause severe adverse effects for at least 2 weeks in mice.

Animal Model:	Female C57BL/6J mice (E0771) and BALB/c nude mice (HT1080, MDA-MB-231, and AsPC-1) (6 weeks)^[1]
Dosage:	100 mg/kg
Administration:	i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks
Result:	Strikingly suppressed the tumour growth of subcutaneously injected E0771 cells and significantly attenuated tumour growth of MDA-MB-231 and AsPC-1 cells in immunodeficient mice. In turn, naphthofluorescein did not attenuate tumour growth of FIH-1-depleted MDA-MB-231 cells.

NAPHTHOFLUORESCEIN Preparation Products And Raw materials

Raw materials

Preparation Products

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NAPHTHOFLUORESCEIN Suppliers

China 52 Germany 1 Switzerland 2 United States 6 Global 61

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61419-02-1, NAPHTHOFLUORESCEINRelated Search:

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NAPHTHOFLUORESCEIN

NAPHTHOFLUORESCEIN, FOR FLUORESCENCE

NAPHTHOFLUORESCEIN FOR FLUORESCENCE 95+%

Naphthafluorescein

Spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one,3,11-dihydroxy-

61419-02-1

Detection

Fluorescent Probes, Labels, Particles and Stains

BioChemical

Biochemicals and Reagents