NAPHTHOFLUORESCEIN
- Product Name
- NAPHTHOFLUORESCEIN
- CAS No.
- 61419-02-1
- Chemical Name
- NAPHTHOFLUORESCEIN
- Synonyms
- Naphthafluorescein;NAPHTHOFLUORESCEIN;NAPHTHOFLUORESCEIN, FOR FLUORESCENCE;NAPHTHOFLUORESCEIN FOR FLUORESCENCE 95+%;Spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one,3,11-dihydroxy-
- CBNumber
- CB1689770
- Molecular Formula
- C28H16O5
- Formula Weight
- 432.42
- MOL File
- 61419-02-1.mol
NAPHTHOFLUORESCEIN Property
- Melting point:
- 189 °C (dec.)(lit.)
- Boiling point:
- 755.5±60.0 °C(Predicted)
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: soluble
- form
- A crystalline solid
- pka
- 8.82±0.20(Predicted)
- color
- Purple to purplish red
- BRN
- 61335
- InChIKey
- IXQIUDNVFVTQLJ-UHFFFAOYSA-N
- EPA Substance Registry System
- Spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one, 3,11-dihydroxy- (61419-02-1)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 70420
- Product name
- Naphthofluorescein
- Purity
- suitable for fluorescence
- Packaging
- 100mg
- Price
- $85.7
- Updated
- 2024/03/01
- Product number
- 70420
- Product name
- Naphthofluorescein
- Purity
- suitable for fluorescence
- Packaging
- 500mg
- Price
- $311
- Updated
- 2024/03/01
- Product number
- 13055
- Product name
- Naphthofluorescein
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 13055
- Product name
- Naphthofluorescein
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 13055
- Product name
- Naphthofluorescein
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $214
- Updated
- 2024/03/01
NAPHTHOFLUORESCEIN Chemical Properties,Usage,Production
Uses
Naphthofluorescein is a furin inhibitor.
Uses
Naphtofluorescein is a pH-sensitive fluorescent probe, also used for preparation of labels and enzyme substrates.
Definition
ChEBI: Naphthofluorescein is a member of xanthenes.
in vivo
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks)does not show weight loss or apparent histological abnormalities in the lung, liver, and kidney, or cause cause severe adverse effects for at least 2 weeks in mice[1].
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks) strikingly suppresses the tumour growth of subcutaneously injected E0771 cells and significantly attenuates tumour growth of MDA-MB-231 and AsPC-1 cells in immunodeficient mice. In turn, naphthofluorescein does not attenuate tumour growth of FIH-1-depleted MDA-MB-231 cells[1].
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks) suppresses tumour growth in human cancer cells in an FIH-1-dependent manner[1].
| Animal Model: | Male C57BL/6J mice (8 weeks)[1] |
| Dosage: | 100 mg/kg |
| Administration: | i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks |
| Result: | Neither showed weight loss or apparent histological abnormalities in the lung, liver, and kidney, or caused cause severe adverse effects for at least 2 weeks in mice. |
| Animal Model: | Female C57BL/6J mice (E0771) and BALB/c nude mice (HT1080, MDA-MB-231, and AsPC-1) (6 weeks)[1] |
| Dosage: | 100 mg/kg |
| Administration: | i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks |
| Result: | Strikingly suppressed the tumour growth of subcutaneously injected E0771 cells and significantly attenuated tumour growth of MDA-MB-231 and AsPC-1 cells in immunodeficient mice. In turn, naphthofluorescein did not attenuate tumour growth of FIH-1-depleted MDA-MB-231 cells. |
NAPHTHOFLUORESCEIN Preparation Products And Raw materials
Raw materials
Preparation Products
NAPHTHOFLUORESCEIN Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71