TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE
- Product Name
- TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE
- CAS No.
- 183741-80-2
- Chemical Name
- TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE
- Synonyms
- 3-(Boc-amino)-6-methoxypyridine;tert-Butyl (6-methoxypyridin-3-yl);tert-butyl 6-Methoxypyridin-3-ylcarbaMate;TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE;tert-Butyl N-(6-methoxypyridin-3-yl)carbamate;(6-Methoxy-pyridin-3-yl)-carbaMic acid tert-butyl ester;(6-Methoxy-3-pyridinyl)-carbamic acid 1,1-dimethylethyl ester;Carbamic acid, N-(6-methoxy-3-pyridinyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB1690048
- Molecular Formula
- C11H16N2O3
- Formula Weight
- 224.26
- MOL File
- 183741-80-2.mol
TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE Property
- Boiling point:
- 278.6℃
- Density
- 1.146
- Flash point:
- 122.3℃
- storage temp.
- 2-8°C
- pka
- 12.34±0.70(Predicted)
- Appearance
- Off-white to pale purple Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T135780
- Product name
- tert-Butyl6-Methoxypyridin3-ylcarbamate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB54415
- Product name
- tert-Butyl-n-(6-methoxy-3-pyridyl)carbamate
- Packaging
- 250mg
- Price
- $77.5
- Updated
- 2021/12/16
- Product number
- FB54415
- Product name
- tert-Butyl-n-(6-methoxy-3-pyridyl)carbamate
- Packaging
- 500mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- Z3431
- Product name
- tert-ButylN-(6-methoxypyridin-3-yl)carbamate
- Packaging
- 1g
- Price
- $278
- Updated
- 2021/12/16
- Product number
- FB54415
- Product name
- tert-Butyl-n-(6-methoxy-3-pyridyl)carbamate
- Packaging
- 1g
- Price
- $316.3
- Updated
- 2021/12/16
TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE Chemical Properties,Usage,Production
Synthesis
6628-77-9
24424-99-5
183741-80-2
The general procedure for the synthesis of 3-(Boc-amino)-6-methoxypyridine from 5-amino-2-methoxypyridine and di-tert-butyl dicarbonate was as follows: 1.0 g of 5-amino-2-methoxypyridine was placed in a single-neck flask and dissolved in 40 mL of dioxane. Subsequently 1.79 g of di-tert-butyl dicarbonate was added and the reaction mixture was heated to reflux overnight. After completion of the reaction, it was cooled to room temperature and the solvent was removed by evaporation under reduced pressure. The resulting residue was purified by silica gel column chromatography using a solvent mixture of heptane and ethyl acetate (the volume ratio was tapered from 90/10 to 70/30) as eluent for gradient elution. Finally, 1.58 g of the target product 3-(Boc-amino)-6-methoxypyridine was obtained in 97% yield.
References
[1] Patent: US2011/178053, 2011, A1. Location in patent: Page/Page column 46
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 12, p. 3303 - 3306
[3] Journal of the Chemical Society - Perkin Transactions 1, 1996, # 18, p. 2221 - 2226
[4] Tetrahedron Letters, 2011, vol. 52, # 41, p. 5292 - 5296
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 12, p. 5053 - 5074
TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE Preparation Products And Raw materials
Raw materials
Preparation Products
TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE Suppliers
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- Country
- India
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View Lastest Price from TERT-BUTYL-N-(6-METHOXY-3-PYRIDYL)CARBAMATE manufacturers
- Product
- tert-Butyl-n-(6-Methoxy-3-pyridyl)carbaMate 183741-80-2
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%minNMR
- Supply Ability
- 50kgs/month
- Release date
- 2022-04-17