Butyl chloroformate
- Product Name
- Butyl chloroformate
- CAS No.
- 592-34-7
- Chemical Name
- Butyl chloroformate
- Synonyms
- butyl carbonochloridate;BUTYL CHLOROFORMATE;n-Buty chloroformate;N-BUTYL CHLOROFORMATE;Butyl chlorocarbonate;Butyl chloridocarbonate;Butoxycarbonyl chloride;BUTYL CHLOROCARBOXYLATE;N-Butyl Chlorocarbonate;Butyl chloroformate,98%
- CBNumber
- CB1692042
- Molecular Formula
- C5H9ClO2
- Formula Weight
- 136.58
- MOL File
- 592-34-7.mol
Butyl chloroformate Property
- Melting point:
- -70 °C
- Boiling point:
- 142 °C(lit.)
- Density
- 1.074 g/mL at 25 °C(lit.)
- vapor pressure
- 2.42 psi ( 20 °C)
- refractive index
- n20/D 1.412(lit.)
- Flash point:
- 77 °F
- storage temp.
- 2-8°C
- form
- Liquid
- color
- Clear
- Water Solubility
- DECOMPOSES
- Sensitive
- Moisture Sensitive
- BRN
- 605635
- LogP
- 1.895 (est)
- CAS DataBase Reference
- 592-34-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Carbonochloridic acid, butyl ester(592-34-7)
- EPA Substance Registry System
- n-Butyl chloroformate (592-34-7)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H314Causes severe skin burns and eye damage
H331Toxic if inhaled
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 184462
- Product name
- Butyl chloroformate
- Purity
- 98%
- Packaging
- 100g
- Price
- $145
- Updated
- 2026/03/19
- Product number
- B692725
- Product name
- Butyl chloroformate
- Packaging
- 5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB05915
- Product name
- Butyl chloroformate
- Packaging
- 250g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FB05915
- Product name
- Butyl chloroformate
- Packaging
- 500g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FB05915
- Product name
- Butyl chloroformate
- Packaging
- 1kg
- Price
- $300
- Updated
- 2021/12/16
Butyl chloroformate Chemical Properties,Usage,Production
Chemical Properties
clear liquid
Uses
Butyl Chloroformate is a reactant in the preparation of Lapatinib derivatives as HER1/HER2 targeting antitumor drugs.
General Description
A colorless liquid. Flash point near 70°F. Very toxic by inhalation. Denser than water. Used to make other chemicals.
Air & Water Reactions
Highly flammable. Decomposes exothermically in water to give hydrochloric acid and organic acids.
Reactivity Profile
Butyl chloroformate is incompatible with bases (including amines), with water, with strong oxidizing agents, with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
Inhalation of vapor irritates nose and throat and can cause delayed pulmonary edema. Liquid irritates eyes and causes severe skin burns and irreversible skin damage if allowed to remain. Can cause blindness. Ingestion causes burns of mouth and stomach.
Flammability and Explosibility
Flammable
Synthesis
The n-butyl chloroformate was prepared as follows: 1580g of n-butanol (M=74) was preheated to 100C, added from the upper inlet of the reaction distillation tower using a stratospheric pump, and fully contacted with the phosgene gas (0.5MPa, M=98.9) entering from the lower inlet in the reaction section, which was 100C. The liquid hydrogen chloride and the excess of hydrogen chloride were separated by deep condensation at -40C through a heat exchanger into the reaction distillation tower for reuse. The generated hydrogen chloride and excess phosgene enter the subsequent recovery unit through the top of the tower and are separated by deep condensation at -40C. The liquid phosgene passes through a heat exchanger into the reaction distillation tower for reuse, and the hydrogen chloride gas is passed into a 1.0 wt% NaOH aqueous solution for absorption. The n-butyl chloroformate as a single product stream passes through the tower kettle into the storage tank for subsequent use. The composition of the reaction solution was analyzed by gas chromatography, which showed that the conversion of butanol was >99.9% and the selectivity of chloroformate was >99.9%.
Butyl chloroformate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Butyl chloroformate manufacturers
- Product
- Butyl chloroformate 592-34-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-03
- Product
- Butyl chloroformate 592-34-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.99
- Supply Ability
- 10Ton
- Release date
- 2021-03-17
- Product
- Butyl chloroformate 592-34-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-15