ChemicalBook > CAS DataBase List > 3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE

3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE

Product Name
3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE
CAS No.
93246-53-8
Chemical Name
3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE
Synonyms
3-FLUORO-4-MORPHOLINOANILINE;Linezolid AMine IMpurity;AKOS B033533;TIMTEC-BB SBB010944;Linezolid Impurity 28;Linezolid Intermediate 1;3-Fluoro-4-morpholinoanili;3-Fluoro-4-morpholin-4-yl-;3-FLUORO-4-MORPHOLIN-ANILINE;Linezolid Phenylamine Impurity
CBNumber
CB1698428
Molecular Formula
C10H13FN2O
Formula Weight
196.22
MOL File
93246-53-8.mol
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3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE Property

Melting point:
121-123°C
Boiling point:
364.9±42.0 °C(Predicted)
Density 
1.232±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform, Methanol
form 
Solid
pka
6.53±0.40(Predicted)
color 
Off-White to Brown
InChI
InChI=1S/C10H13FN2O/c11-9-7-8(12)1-2-10(9)13-3-5-14-6-4-13/h1-2,7H,3-6,12H2
InChIKey
FQGIBHQUVCGEAC-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(N2CCOCC2)C(F)=C1
CAS DataBase Reference
93246-53-8(CAS DataBase Reference)
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Safety

HazardClass 
IRRITANT
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
F0849
Product name
3-Fluoro-4-morpholinoaniline
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$89
Updated
2025/07/31
TCI Chemical
Product number
F0849
Product name
3-Fluoro-4-morpholinoaniline
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$269
Updated
2025/07/31
TRC
Product number
F595895
Product name
3-Fluoro-4-(4-morpholinyl)Benzenamine
Packaging
1g
Price
$50
Updated
2021/12/16
Matrix Scientific
Product number
051328
Product name
3-Fluoro-4-(4-morpholinyl)aniline
Packaging
25g
Price
$34
Updated
2021/12/16
AK Scientific
Product number
W9598
Product name
3-Fluoro-4-morpholinoaniline
Packaging
25g
Price
$45
Updated
2021/12/16
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3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Uses

Intermediate in the synthesis of Linezolid (L466500).

Definition

ChEBI: 3-Fluoro-4-morpholinoaniline is a member of morpholines.

Synthesis

2689-39-6

93246-53-8

The general procedure for the synthesis of 3-fluoro-4-(4-morpholinyl)aniline from 3-fluoro-4-(4-morpholinyl)nitrobenzene was as follows: 4-(2-fluoro-4-nitrophenyl)morpholine D1 (42.6 g, 0.19 mol) was dissolved in ethanol (1.2 L), 10% Pd/C catalyst (4 g) was added, and hydrogenation was carried out at standard temperature and pressure (STP) for 18 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was evaporated under vacuum to afford the target product 3-fluoro-4-(4-morpholinyl)aniline (36.9 g, 100% yield) as a colorless solid. The structure of the product was confirmed by 1H NMR (CDCl3): δ 2.96 (4H, m), 3.55 (2H, br s), 3.84 (4H, m), 6.41 (2H, m), 6.79 (1H, m).

References

[1] Patent: WO2005/58317, 2005, A1. Location in patent: Page/Page column 35
[2] Patent: WO2005/58885, 2005, A2. Location in patent: Page/Page column 33
[3] Patent: WO2005/75461, 2005, A1. Location in patent: Page/Page column 100
[4] Patent: WO2006/2956, 2006, A1. Location in patent: Page/Page column 31
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 9, p. 4052 - 4066

3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE Suppliers

Americas 1 Belgium 1 Canada 2 China 304 Europe 2 France 1 Germany 3 India 33 Japan 1 United Kingdom 6 United States 37 Global 391
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
ecochem international chemical broker
Tel
--
Fax
--
Email
export@ecochem.dk
Country
Europe
ProdList
6371
Advantage
66
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View Lastest Price from 3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE 93246-53-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98
Supply Ability
10000KGS
Release date
2025-12-05
Hebei Chuanghai Biotechnology Co., Ltd
Product
3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE 93246-53-8
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-22
Longyan Tianhua Biological Technology Co., Ltd
Product
3-FLUORO-4-MORPHOLIN-ANILINE 93246-53-8
Price
US $21.00/Kg/Bag
Min. Order
25Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2020-11-02

93246-53-8, 3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINERelated Search:

Linezolid 4-(2-FLUORO-4-NITRO-PHENYL)-MORPHOLINE (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate O-descarbonyl O-Acetyl Linezolid Linezolid Impurity 33 Linezolid Impurity 56 DeacetaMide Linezolid PhthaliMide Linezolid IMpurity D HCl Linezolid Related Impurity 1 Desacetyl-N,O-descarbonyl Linezolid Linezolid Impurity 21 Linezolid Diphthalimide Linezolid Impurity 37 Linezolid Impurity 24 Linezolid Impurity 25 Linezolid Impurity 34 Linezolid Impurity 57 (R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone

  • AKOS B033533
  • 3-FLUORO-4-(4-MORPHOLINYL)-BENZEAMINE
  • 3-FLUORO-4-(4-MORPHOLINYL)-BENZENAMINE
  • 3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE
  • 3-FLUORO-4-MORPHOLIN-ANILINE
  • 3-FLUORO-4-MORPHOLINOANILINE
  • 3-FLUORO-4-MORPHOLINOPHENYLAMINE
  • TIMTEC-BB SBB010944
  • Linazolamide intermediate B impurity 4
  • 3-Fluoro-4-(4-morpholinyl)aniline
  • 3-fluoro-4-morpholin-4-ylaniline
  • 3-fluoro-4-morpholinobenzenamine
  • 3-fluoro-4-(4-morpholinyl)aniline(SALTDATA: HCl)
  • Linezolid Intermediate 1
  • 3- fluorine-4-(4- Morphine groups)aniline
  • N-(4-AMino-2-fluorophenyl)Morpholine.
  • 4-(2-Fluoro-4-aminophenyl)morpholine
  • BenzenaMine, 3-fluoro-4-(4-Morpholinyl)-
  • Linezolid AMine IMpurity
  • 3-FLUORO3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE
  • 3-Fluoro-4-morpholinoanili
  • Linezolid Impurity 28
  • 3-Fluoro-4-morpholinoaniline&gt
  • Linezolid Phenylamine Impurity
  • 3-Fluoro-4-morpholinoaniline, 98+%
  • 3-Fluoro-4-(4-morpholinyl)-benzamine
  • 3-Fluoro-4-morpholin-4-yl-
  • 3-Fluoro-4-morpholinoaniline 98%
  • 93246-53-8
  • 93246-53-81
  • C10H13FN2O
  • linezolid intermediate
  • Agonist