(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate

Product Name: (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
CAS No.: 174649-09-3
Chemical Name: (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
Synonyms: Linezolid related Compound;Linezolid USP RC D;Unezolld Impurlty 47;Linezolid Impurity 32;Mesylate imp USP RC-D;Linezolid Impurity1318;Linezolid impurity D RS;Linezolid Related Compound 1;Linezolid USP Related Compound D;Linezolid Related Compound D (Linezolid Mesylate Impurity)
CBNumber: CB02510028
Molecular Formula: C15H19FN2O6S
Formula Weight: 374.38
MOL File: 174649-09-3.mol

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(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Property

Melting point:: 183-185℃
Boiling point:: 592.7±50.0 °C(Predicted)
Density: 1.418
storage temp.: 2-8°C
solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 5.71±0.40(Predicted)
color: White to Off-White

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Safety

HS Code: 2934990002

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F594970
Product name: (5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-[[(methylsulfonyl)oxy]methyl]-2-oxazolidinone
Packaging: 100mg
Price: $1455
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 51408
Product name: (5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-[[(methylsulfonyl)oxy]methyl]-2-oxazolidinone
Packaging: 100mg
Price: $1475
Updated: 2021/12/16

Matrix Scientific

Product number: 094498
Product name: (R)-(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate
Purity: 95+%
Packaging: 1g
Price: $1647
Updated: 2021/12/16

AK Scientific

Product number: 9040AA
Product name: LinezolidRelatedCompoundD
Packaging: 25mg
Price: $39
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IF58046
Product name: (R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate
Packaging: 10g
Price: $70
Updated: 2021/12/16

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(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Chemical Properties,Usage,Production

Uses

(5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-[[(methylsulfonyl)oxy]methyl]-2-oxazolidinone (Linezolid USP Related Compound D) is an intermediate in the synthesis of Linezolid Dimer (L466520), an impurity of the antibacterial agent Linezolid (L466500).

Synthesis

124-63-0

168828-82-8

174649-09-3

To a 1L solution of dichloromethane containing 132.8 g of (R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-5-hydroxymethyl-2-oxazolidinone and 87.1 g of triethylamine was slowly added 74 g of methanesulfonyl chloride at 0°C under nitrogen protection. The reaction mixture was stirred at 0 °C for 30 min and then gradually warmed up to room temperature. A white solid precipitated during the reaction. Subsequently, a solvent mixture consisting of 1.75 L of water, 6.50 L of dichloromethane and 1 L of ethyl acetate was added to the reaction system and stirring was continued for 30 minutes. Upon completion of the reaction, the white solid product was collected by filtration. A final product of 140 g was obtained with a yield of 105.42% (w/w).

References

[1] Patent: WO2009/63505, 2009, A2. Location in patent: Page/Page column 14
[2] Patent: EP2163547, 2010, A1. Location in patent: Page/Page column 8
[3] Patent: WO2011/77310, 2011, A1. Location in patent: Page/Page column 12; 13
[4] Synthetic Communications, 2010, vol. 40, # 6, p. 789 - 798
[5] Patent: WO2010/84514, 2010, A2. Location in patent: Page/Page column 15

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Suppliers

China 145 India 10 United Kingdom 1 United States 6 Global 162

J & K SCIENTIFIC LTD.

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View Lastest Price from (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (R)-(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate 174649-09-3
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-29

Career Henan Chemical Co

Product: (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate 174649-09-3
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: ask
Release date: 2018-12-19

174649-09-3, (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonateRelated Search:

Linezolid Diphthalimide Linezolid (S)-N-((3-(3-fluoro-4-Morpholinophenyl)-2-oxooxazolidin-5-yl)Methyl)ethanethioaMide (S)-N-(3-Chloro-2-hydroxypropyl)acetamide 4-(2-BROMO-4-NITROPHENYL)MORPHOLINE (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione (R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone O-descarbonyl O-Acetyl Linezolid Linezolid Impurity 34 Linezolid Impurity 11 3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE 2-amino-3-chloropropan-1-ol hydrochloride (R)-1-Amino-3-chloro-2-propanol hydrochloride N-[(2R)-3-[[3-Fluoro-4-(4-Morpholinyl)phenyl]aMino]-2-hydroxypropyl]acetaMide N-(3-PhthaliMido-2-(R)-hydroxypropyl)-3-fluoro-4-(Morpholinyl)aniline 1-ACETAMIDO-ACETONE N-[[(5R)-3-[3-Fluoro-4-(4-Morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]Methyl]acetaMide Bis-Linezolid

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate

(R)-[3-(3-Fluoro-4-Morpholinophenyl)-2-oxo-5-oxazolidinyl]Methyl Methanesulfonat

(R)-(3-(3-flouro-4-Morpholinophenyl)-2-oxo-5-oxazolidinyl)Methyl Methanesulfonate

(R)-(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate

(5R)-3-[3-Fluoro-4-(4-Morpholinyl)phenyl]-5-[[(Methylsulfonyl)oxy]Methyl]-2-oxazolidinone

2-Oxazolidinone, 3-[3-fluoro-4-(4-Morpholinyl)phenyl]-5-[[(Methylsulfonyl)oxy]Methyl]-, (5R)-

Linezolid related Compound

Linezolid USP RC D

(R)-N-(3-(3-Fluoro-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methanol mesylate

Linezolid Impurity 32

(R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate

Linezolid USP Related Compound D

Linezolid Related Compound 1

Linezolid Related Compound D (Linezolid Mesylate Impurity)

Mesylate imp USP RC-D

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]me...

Linezolid Impurity1318

TIANFU-CHEM --(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate

Unezolld Impurlty 47

(R) - N - [3- (3-fluoro - (4-morpholino) phenyl) -2-oxo-5-oxazolyl] methanesulfonate

(R)-Methanesulfonic acid 3-(3-fluoro-4- morpholin-4-yl- phenyl)-2-oxo- oxazolidin-5-ylmethyl

(5R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl]methyl Methanesulfonate

(R)-N-[3-(3-Fluoro-4-(morpholin-4-yl)phenyl)-2-oxo-5-oxazolidinyl]methanolMethanesulfonate

(R)-(3-(3-FLUORO-4-MORPHOLINOPHENYL)-2- OXOOXAZOLIDIN-5-YL)METHYL METHANESULFONATE / LINEZOLID RELATED COMPOUND D

Linezolid impurity D RS

174649-09-3

185608-75-8