(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione

Product Name: (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione
CAS No.: 168828-82-8
Chemical Name: (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione
Synonyms: PNU100440;PNU 100440;PNU-100440;Linezolid-12;Linezolid-003-R;Linezolid impurity E;PNU100440,PNU 100440;Linezolid Impurity 46;Linezolid Impurity210;Linezolid InterMediate
CBNumber: CB5684900
Molecular Formula: C14H17FN2O4
Formula Weight: 296.29
MOL File: 168828-82-8.mol

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(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione Property

Melting point:: 110-112 °C
Boiling point:: 494.2±45.0 °C(Predicted)
Density: 1.361±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 14.05±0.10(Predicted)
color: White to Pale Red
optical activity: -56.8447°(C=0.805g/100ml CHCL3)
CAS DataBase Reference: 168828-82-8(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F594975
Product name: [(R)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methanol
Packaging: 100mg
Price: $185
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IF58045
Product name: (R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one
Packaging: 100g
Price: $280
Updated: 2021/12/16

Matrix Scientific

Product number: 119476
Product name: (R)-3-(3-Fluoro-4-morpholinophenyl)-5-(hydroxymethyl)oxazolidin-2-one
Purity: 95+%
Packaging: 1g
Price: $324
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IF58045
Product name: (R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one
Packaging: 250g
Price: $550
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 51409
Product name: [(R)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methanol
Packaging: 100mg
Price: $650
Updated: 2021/12/16

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(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione Chemical Properties,Usage,Production

Uses

[(R)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methanol is an intermediate in the synthesis of Linezolid Dimer (L466520), an impurity of the antibacterial agent Linezolid (L466500).

Synthesis

60456-26-0

168828-81-7

168828-82-8

GENERAL STEPS: Example 3: Preparation of (R)-3-[3-fluoro-4-(4-morpholinophenyl)]-5-hydroxymethyl-2-oxazolidinone [131] To a mixed solution of n-butanol (51.5 g) and THF (100 ml) was added slowly at 20-30°C under nitrogen protection n-butyllithium (1.6 M in hexanes, 391.7 g), keeping the reaction temperature at 10-20°C. The process was continued for 45-60 minutes. In another reactor, N-carboxyphenylmethoxy-3-fluoro-4-morpholino aniline (100 g) was dissolved in THF (500 ml) under nitrogen protection and stirred at 20-30 °C. Subsequently, the mixture was cooled to -15 to -5°C, and the n-butyllithium solution prepared as described previously was slowly added, maintaining the temperature at -15 to -5°C for 45-60 minutes of reaction. Then, (R)-(-)-glycidyl butyrate (48.0 g) was slowly added to this solution and kept at -10 to -5°C for 1 hour. After the addition was completed, the reaction temperature was raised to 8-13°C maintained at 8-13°C for 1 hr, and then raised to 13-15°C for 4-5 hrs of reaction. After completion of the reaction, water (800 ml) and ethyl acetate (300 ml) were added for layering. The organic layer was washed with ethyl acetate-hexane mixture and the solid was dried in an air pan drier at 55-60 °C. Yield: 0.765 g in 85% yield. [132]

References

[1] Synthetic Communications, 2010, vol. 40, # 6, p. 789 - 798
[2] Patent: WO2011/77310, 2011, A1. Location in patent: Page/Page column 12
[3] Organic Syntheses, 2005, vol. 81, p. 112 - 120
[4] Patent: WO2013/111048, 2013, A1. Location in patent: Page/Page column 19; 20
[5] Patent: US2015/25236, 2015, A1. Location in patent: Paragraph 0131; 0132

(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione Preparation Products And Raw materials

Raw materials

Preparation Products

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(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione Suppliers

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View Lastest Price from (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione manufacturers

Qiuxian Baitai New Material Co., LTD

Product: (5R)-3-[3-fluoro-4 -(4-morpholine) phenyl] -5-hydroxymethyl-2-oxazolidone 168828-82-8
Price: US $2.00/g
Min. Order: 1KG
Purity: 99%
Supply Ability: 5ton/Month
Release date: 2021-12-21

Career Henan Chemical Co

Product: (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione 168828-82-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-08-20

Shanghai Yingrui Biopharma Co., Ltd.

Product: (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione 168828-82-8
Price: US $0.00/KG
Min. Order: 0KG
Purity: 99%
Supply Ability: 100t
Release date: 2018-03-06

168828-82-8, (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidioneRelated Search:

Tetrakis(hydroxymethyl)phosphonium sulfate Diphenyl ether methylol cellulose Methyltriphenylphosphonium bromide CARBOXYMETHYLCELLULOSE SODIUM SALT Dichloromethylphenylsilane Tetrakis(hydroxymethyl)phosphonium chloride PHENYL VALERATE 2-Hydroxyethyl methacrylate Trimethylolpropane Tris(hydroxymethyl)aminomethane PHENYL RESIN Fluorine Phenylacetic acid 3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE (R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE (R)-5-(HYDROXYMETHYL)-3-METHYLOXAZOLIDIN-2-ONE (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione

2-Oxazolidinone, 3-[3-fluoro-4-(4-morpholinyl)phenyl]-5-(hydroxymethyl)-, (5R)-

3-(3-FLUORO-4-(4-MORPHOLINYL)PHENYL)-5-HYDROXYMETHYL-(5R)-2-OXAZOLIDIONE

(R)-3-(3-FLUORO-4-MORPHOLINOPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE

R-N-(3-FLUORO-4-MORPHOLINYLPHENYL)-2-OXO-5-OXAZOLIDINYLMETHANOL

(5R)-3-[3-FLUORO-4-(4-MORPHOLINYL)PHENYL]-5-(HYDROXYMETHYL)-2-OXAZOLIDINONE

5-hydroxymethyl-2-ox azolidione

Linezolid impurity PNU100440

(R)-3-(3-fluoro-4-morpholinophenyl)

Linezolid impurity 12/(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione

Linezolid-12

Linezolid Hydroxymethyl Impurity

Linezolid Hydroxy Impurity

Linezolid Impurity 46

3-[3-fluoro-4-(4-morpholinyl)phenyl]-5-(hydroxymethyl)oxazolidine-2,4-dione

2-Oxazolidinone,3-[3-fluoro-4-(4-morpholinyl)phen

R)-5-(Hydroxymethyl)-3-(3-fluoro-4-morpholinopheny

(5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-(hydroxymethyl)-2-oxazolindinone

(5R)-3-(3-FLUORO-4-(4-MORPHOLINYL)PHENYL)-5-HYDROXYMETHYL-2-OXAZOLIDIONE

R-N-[[3-[3-FLUORO-4-MORPHOLINYL]PHENYL]-2-OXO-5-OXAZOLIDINYL]METHANOL

(5R)-3-(3-Fluoro-4-Morpholin-4-yl-phenyl)-5-hydroxyMethyl-oxazolidin-2-one

[(R)-3-(3-Fluoro-4-Morpholinophenyl)-2-oxo-5-oxazolidinyl]Methanol

Linezolid InterMediate

(5R)-3-(3-fluoro-4-Morpholinophenyl)-5-(hydroxyMethyl)oxazolidin-2-one

(5R)-3-[3-fluoro-4-(Morpholin-4-yl)phenyl]-5-(hydroxyMethyl)-1,3-oxazolidin-2-one

(R)-5-( hydroxy)-3(3-fluoro-4-Morpholinphenyl)oxazolidin-2-one

3-[3-fluoro-4-(4-Morpholinyl)phenyl]-5-(hydroxyMethyl)- (5R)-2-Oxazolidinone

(R)-3-(3-Fluoro-4-Morpholin-4-ylphenyl)-5-(hydroxyMethyl)oxazolidine-2,4-dione

(R)-N-(3-(3-FLuORO-(4-MORPHOLINYL)PHENYL)-2-OXO-5-OXAZOLIDINYL)METHANAOL MESYLATE

Linezolid DesacetaMide Hydroxy IMpurity

(5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-(hydroxymethyl)--oxazolidione

(5R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one

Linezolid impurity E

(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione 98%

Linezolid Impurity ((5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-hydroxymethyl-2-oxazolidinone)

Linezolid-003-R

(R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one

Linezolid Hydroxymethyl Impurity (Linezolid Desacetamide Hydroxy Impurity)

Linezolid hydroxymethyl imp(R-isomer)

(5R)-3-[3-fluoro-4 -(4-morpholine) phenyl] -5-hydroxymethyl-2-oxazolidone

(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-...

Linezolid Impurity210

Linezolid Impurity1306

(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2- 168828-82-8

PNU 100440

PNU100440

PNU-100440

PNU100440,PNU 100440

Unezolld Desacetamlde Hydroxy

(5R)-3-[3-fluoro-4 -(4-morphinyl) phenyl] -5-hydroxymethyl-2-oxazolidinone

5(R)-Hydroxymethyl-3-[3-fluoro-4-(4-morpholinyl)phenyl]oxazolidin-2-one

(R) - (3 - (3 -flour o - 4 - morph olinophenyl) - 2 - o xo - 5 - ox a zo lidinyl)methyl

(5R)-3-(3-Fluoro-4- morpholin-4-yl-phenyl)-(5R) -hydroxymethyl- oxazolidin-2-one

(R)-3-(3-Fluoro-4-morpholinophenyl)-5-(hydroxymethyl)oxazolidin-2-one (Linezolid Impurity)

PNU-100440, 10 mM in DMSO

(R)-[3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl]methanol

168828-82-8

C14H17FN2O4