4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid

Product Name: 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid
CAS No.: 175281-76-2
Chemical Name: 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid
Synonyms: RMA-280;4-(4-(1-Hydroxyethyl);HYDROXYETHYL PHOTOLINKER;-2-methoxy-5-nitrophenoxy);HYDROXYETHYL PHOTOLINKER 1 G;Hydroxyethyl photolinker Novabiochem;4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophen;4-(4-(1-HYDROXYETHYL)-2-METHOXY-5-NITRO-PHENOXY)BUTYRIC ACID;4-[4-(1-HYDROXYETHYL)-2-METHOXY-5-NITROPHENOXY)BUTANOIC ACID;4-[4-(1-Hydroxyethyl)-2-methoxy-6-nitrophenoxy]butanoic Acid
CBNumber: CB1699531
Molecular Formula: C13H17NO7
Formula Weight: 299.28
MOL File: 175281-76-2.mol

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4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid Property

Melting point:: 163-166 °C
Boiling point:: 540.1±50.0 °C(Predicted)
Density: 1.333±0.06 g/cm3(Predicted)
storage temp.: Store below +30°C.
solubility: DMSO (Sparingly), Methanol (Slightly)
form: Solid
pka: 4.54±0.10(Predicted)
color: Yellow
optical activity: 0.3°(C=0.01g/ml DMF)
BRN: 7717635

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 8-10
HS Code: 2918 99 90

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 55262
Product name: 4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butyric acid
Purity: ≥98.0% (HPLC)
Packaging: 1g
Price: $899
Updated: 2025/07/31

TRC

Product number: H825255
Product name: 4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoicAcid
Packaging: 1g
Price: $275
Updated: 2021/12/16

Activate Scientific

Product number: AS146018
Product name: 4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butanoicacid
Purity: 95%
Packaging: 1g
Price: $354
Updated: 2021/12/16

Matrix Scientific

Product number: 093753
Product name: 4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butanoic acid
Purity: 95+%
Packaging: 250mg
Price: $492
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0115079
Product name: 4-[4-(1-HYDROXYETHYL)-2-METHOXY-5-NITROPHENOXY]BUTYRIC ACID
Purity: 95.00%
Packaging: 1G
Price: $750.75
Updated: 2021/12/16

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4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

It is used as a photolabile linker for the preparation of carboxylic acids.

Uses

4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid is used for preparation of photolabile linking groups for use in solid phase synthesis.

reaction suitability

reagent type: cross-linking reagent

Synthesis

1073426-06-8

175281-76-2

General procedure for the synthesis of 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoic acid from ethyl 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoate: ethyl 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoate (8.53 g) was dissolved in a mixture of trifluoroacetic acid (10 mL) and water ( 100 mL) in a mixed solvent, heated to 80 °C and maintained for 18 hours. The progress of the reaction was monitored by 1H NMR and the conversion was found to be incomplete. Subsequently, additional trifluoroacetic acid (5 mL) was added and the reaction was continued for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and a solid precipitate was precipitated, which was collected by filtration. Finally, the resulting solid was freeze-dried to afford the target product 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoic acid (8.53 g, 86% yield) as a yellow powder.1H NMR (δ, ppm, acetone-d6): 1.53 (d, CHCH3), 2.12 (p, ArOCH2CH2CH2), 2.55 (t , ArOCH2CH2CH2), 4.03 (s, ArOCH3), 4.16 (m, ArOCH2), 5.47 (q, CHCH3), 7.47 (d, neighboring aromatic H of ArOCH2), 7.59 (s, neighboring aromatic H of ArOCH3).

References

[1] Patent: US8343710, 2013, B1. Location in patent: Page/Page column 14; 16
[2] Patent: WO2018/57941, 2018, A1. Location in patent: Page/Page column 39; 43; 44
[3] Soft Matter, 2011, vol. 7, # 10, p. 4881 - 4887
[4] Patent: WO2014/197991, 2014, A1. Location in patent: Paragraph 00199-00200
[5] Patent: US2016/370376, 2016, A1. Location in patent: Paragraph 0120

4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid Suppliers

Canada 1 China 81 India 3 Japan 1 Switzerland 1 United Kingdom 1 United States 10 Global 98

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Sigma-Aldrich

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View Lastest Price from 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid manufacturers

PNP Biotech Co. Ltd

Product: 4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoic Acid 175281-76-2
Price: US $0.00/KG
Min. Order: 25KG
Purity: 97%
Supply Ability: Inquiry
Release date: 2022-09-19

Career Henan Chemical Co

Product: 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid 175281-76-2
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-13

175281-76-2, 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic AcidRelated Search:

Hydroxyethyl-Photolinker NovaSyn TG resin HYDROXYETHYL-PHOTOLINKER NOVASYN(R) TG RESIN HYDROXYETHYL-PHOTOLINKER AM RESIN 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid 4-(4-HYDROXYMETHYL-2-METHOXY-5-NITROPHENOXY)BUTYRIC ACID 4,5-DIMETHOXY-2-NITROBENZYL ALCOHOL

HYDROXYETHYL PHOTOLINKER

4-[4-(1-HYDROXYETHYL)-2-METHOXY-5-NITROPHENOXY)BUTANOIC ACID

4-(4-(1-HYDROXYETHYL)-2-METHOXY-5-NITRO-PHENOXY)BUTYRIC ACID

4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophen

-2-methoxy-5-nitrophenoxy)

4-(4-(1-Hydroxyethyl)

4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butyric acid≥ 98% (HPLC)

Hydroxyethyl photolinker Novabiochem

4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butyric acid >=98.0% (HPLC)

HYDROXYETHYL PHOTOLINKER 1 G

Butanoic acid, 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]-

4-[4-(1-Hydroxyethyl)-2-methoxy-6-nitrophenoxy]butanoic Acid

4-(4-(1-Hydroxyethyl)-2-Methoxy-5-Nitro-Phenoxy)Butylic Acid

RMA-280

175281-76-2

C13H17NO7

Linkers

Peptide Synthesis

Specialty Synthesis

Bifunctional Crosslinkers

Aromatics