4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid
- Product Name
- 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid
- CAS No.
- 175281-76-2
- Chemical Name
- 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid
- Synonyms
- RMA-280;4-(4-(1-Hydroxyethyl);HYDROXYETHYL PHOTOLINKER;-2-methoxy-5-nitrophenoxy);HYDROXYETHYL PHOTOLINKER 1 G;Hydroxyethyl photolinker Novabiochem;4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophen;4-(4-(1-HYDROXYETHYL)-2-METHOXY-5-NITRO-PHENOXY)BUTYRIC ACID;4-[4-(1-HYDROXYETHYL)-2-METHOXY-5-NITROPHENOXY)BUTANOIC ACID;4-[4-(1-Hydroxyethyl)-2-methoxy-6-nitrophenoxy]butanoic Acid
- CBNumber
- CB1699531
- Molecular Formula
- C13H17NO7
- Formula Weight
- 299.28
- MOL File
- 175281-76-2.mol
4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid Property
- Melting point:
- 163-166 °C
- Boiling point:
- 540.1±50.0 °C(Predicted)
- Density
- 1.333±0.06 g/cm3(Predicted)
- storage temp.
- Store below +30°C.
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- form
- Solid
- pka
- 4.54±0.10(Predicted)
- color
- Yellow
- optical activity
- 0.3°(C=0.01g/ml DMF)
- BRN
- 7717635
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 55262
- Product name
- 4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butyric acid
- Purity
- ≥98.0% (HPLC)
- Packaging
- 1g
- Price
- $899
- Updated
- 2025/07/31
- Product number
- H825255
- Product name
- 4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoicAcid
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- AS146018
- Product name
- 4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butanoicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $354
- Updated
- 2021/12/16
- Product number
- 093753
- Product name
- 4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butanoic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $492
- Updated
- 2021/12/16
- Product number
- CHM0115079
- Product name
- 4-[4-(1-HYDROXYETHYL)-2-METHOXY-5-NITROPHENOXY]BUTYRIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $750.75
- Updated
- 2021/12/16
4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
It is used as a photolabile linker for the preparation of carboxylic acids.
Uses
4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid is used for preparation of photolabile linking groups for use in solid phase synthesis.
reaction suitability
reagent type: cross-linking reagent
Synthesis
1073426-06-8
175281-76-2
General procedure for the synthesis of 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoic acid from ethyl 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoate: ethyl 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoate (8.53 g) was dissolved in a mixture of trifluoroacetic acid (10 mL) and water ( 100 mL) in a mixed solvent, heated to 80 °C and maintained for 18 hours. The progress of the reaction was monitored by 1H NMR and the conversion was found to be incomplete. Subsequently, additional trifluoroacetic acid (5 mL) was added and the reaction was continued for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and a solid precipitate was precipitated, which was collected by filtration. Finally, the resulting solid was freeze-dried to afford the target product 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoic acid (8.53 g, 86% yield) as a yellow powder.1H NMR (δ, ppm, acetone-d6): 1.53 (d, CHCH3), 2.12 (p, ArOCH2CH2CH2), 2.55 (t , ArOCH2CH2CH2), 4.03 (s, ArOCH3), 4.16 (m, ArOCH2), 5.47 (q, CHCH3), 7.47 (d, neighboring aromatic H of ArOCH2), 7.59 (s, neighboring aromatic H of ArOCH3).
References
[1] Patent: US8343710, 2013, B1. Location in patent: Page/Page column 14; 16
[2] Patent: WO2018/57941, 2018, A1. Location in patent: Page/Page column 39; 43; 44
[3] Soft Matter, 2011, vol. 7, # 10, p. 4881 - 4887
[4] Patent: WO2014/197991, 2014, A1. Location in patent: Paragraph 00199-00200
[5] Patent: US2016/370376, 2016, A1. Location in patent: Paragraph 0120
4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid Preparation Products And Raw materials
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View Lastest Price from 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid manufacturers
- Product
- 4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoic Acid 175281-76-2
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 97%
- Supply Ability
- Inquiry
- Release date
- 2022-09-19
- Product
- 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid 175281-76-2
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-13