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Chymotrypsin Substrate II, Fluorogenic

Product Name
Chymotrypsin Substrate II, Fluorogenic
CAS No.
88467-45-2
Chemical Name
Chymotrypsin Substrate II, Fluorogenic
Synonyms
SUC-AAPF-AMC;FACTOR XIIA SUBSTRATE;Z-LYS-PHE-ARG-PNA 2HCL;SUC-ALA-ALA-PRO-PHE-MCA;SUC-ALA-ALA-PRO-PHE-AMC;Z-LYS-PHE-ARG-PNA DIHYDROCHLORIDE;Suc-Ala-Ala-Pro-Phe-AMC≥ 99% (HPLC);FACTOR XIIA SUBSTRATE DIHYDROCHLORIDE;CHYMOTRYPSIN SUBSTRATE II, FLUOROGENIC;5:PN:WO0197794 SEQID:34 claimed protein
CBNumber
CB1701335
Molecular Formula
C34H39N5O9
Formula Weight
661.7
MOL File
88467-45-2.mol
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Chymotrypsin Substrate II, Fluorogenic Property

Boiling point:
1093.0±65.0 °C(Predicted)
Density 
1.347±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Clear, colorless solution (10 mg/mL in Methanol)
form 
White lyophilized solid
pka
4.69±0.10(Predicted)
color 
White to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S9761
Product name
N-Succinyl-Ala-Ala-Pro-Phe-7-amido-4-methylcoumarin
Purity
Leucine aminopeptidase substrate
Packaging
1mg
Price
$94
Updated
2024/03/01
Sigma-Aldrich
Product number
230914
Product name
Chymotrypsin Substrate II, Fluorogenic
Packaging
25mg
Price
$142
Updated
2024/03/01
Sigma-Aldrich
Product number
S9761
Product name
N-Succinyl-Ala-Ala-Pro-Phe-7-amido-4-methylcoumarin
Purity
Leucine aminopeptidase substrate
Packaging
5mg
Price
$315
Updated
2024/03/01
TRC
Product number
C432958
Product name
Chymotrypsin Substrate II, Fluorogenic
Packaging
50mg
Price
$255
Updated
2021/12/16
Chem-Impex
Product number
04643
Product name
Suc-Ala-Ala-Pro-Phe-AMC,99%(HPLC)
Purity
99%(HPLC)
Packaging
50MG
Price
$436.8
Updated
2021/12/16
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Chymotrypsin Substrate II, Fluorogenic Chemical Properties,Usage,Production

Description

Chymotrypsin Substrate II, Fluorogenic finds widespread utility across diverse scientific research applications, encompassing the exploration of protein-protein interactions, enzyme kinetics, and receptor binding. Notably, its cost-effectiveness and user-friendly nature render it an appealing choice for researchers. Additionally, this peptide has been instrumental in delving into the intricate world of cell signaling pathways and unraveling the mechanisms governing gene expression regulation. It is postulated to function as a substrate for enzymes while also engaging with receptors. The prevailing belief suggests that the peptide effectively binds to specific receptors, subsequently triggering their activation and instigating consequential alterations in cellular signaling pathways.

Chemical Properties

White powder

Uses

Chymotrypsin Substrate II, Fluorogenic (cas# 88467-45-2) is a useful compound in organic synthesis and acts as a substrate for chymotrypsin enzyme.

Biological Activity

Sensitive fluorogenic substrate for the quantitative determination of chymotrypsin activity (excitation maximum: ~380 nm; emission maximum: ~460 nm).

References

[1] G B IRVINE C H W M Ennis. Visual detection of peptidase activity using fluorogenic substrates in a microtiter plate assay.[J]. Analytical biochemistry, 1990, 185 2: 304-307. DOI:10.1016/0003-2697(90)90298-n.
[2] LASZLO GRAF. Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin[J]. Biochemistry Biochemistry, 1987, 26 9: 2616-2623. DOI:10.1021/bi00383a031.
[3] OSHIMA G. Interaction of alpha-chymotrypsin with dimyristoyl phosphatidylcholine vesicles.[J]. Journal of biochemistry, 1984, 95 4: 1131-1136. DOI:10.1093/oxfordjournals.jbchem.a134701.
[4] OSHIMA G. Stimulation by phospholipid vesicles of proteolysis of egg white lysozyme by chymotrypsin.[J]. Journal of biochemistry, 1983, 5 1: 1615-1620. DOI:10.1093/OXFORDJOURNALS.JBCHEM.A134509.

Chymotrypsin Substrate II, Fluorogenic Preparation Products And Raw materials

Raw materials

Preparation Products

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Chymotrypsin Substrate II, Fluorogenic Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9979
Advantage
55
Wuhan Henruixintai Biological Co., Ltd.
Tel
027-027-65522215 18163303831
Fax
-
Email
360034463@qq.com
Country
China
ProdList
996
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Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
6756
Advantage
58
Beijing Minruida Technology Co., Ltd.
Tel
010-82387566 18001021521;
Fax
82387566-801
Email
sales@mreda.com.cn
Country
China
ProdList
10789
Advantage
58
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View Lastest Price from Chymotrypsin Substrate II, Fluorogenic manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
FACTOR XIIA SUBSTRATE DIHYDROCHLORIDE 88467-45-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-11

88467-45-2, Chymotrypsin Substrate II, FluorogenicRelated Search:


  • SUCCINYL-L-ALANYL-L-ALANYL-L-PROLYL-L-PHENYLALANINE 4-METHYLCOUMARYL-7-AMIDE
  • SUC-AAPF-AMC
  • SUC-ALA-ALA-PRO-PHE-MCA
  • SUC-ALA-ALA-PRO-PHE-7-AMINO-4-METHYLCOUMARIN
  • SUC-ALA-ALA-PRO-PHE-AMC
  • N-SUCCINYL-ALA-ALA-PRO-PHE 7-AMIDO-4-METHYLCOUMARIN
  • Z-LYS-PHE-ARG-PNA 2HCL
  • Chymotrypsin Substrate II, Fluorogenic - CAS 88467-45-2 - Calbiochem
  • CHYMOTRYPSIN SUBSTRATE II, FLUOROGENIC
  • FACTOR XIIA SUBSTRATE DIHYDROCHLORIDE
  • N-SUCCINYL-ALA-ALA-PRO-PHE 7-AMIDO-4-*ME THYLCOUMARI
  • FACTOR XIIA SUBSTRATE
  • succinylalanylalanyl-prolyl-phenylalanine-4-methylcoumaryl-7-amide
  • Z-LYS-PHE-ARG-PNA DIHYDROCHLORIDE
  • Suc-Ala-Ala-Pro-Phe-AMC≥ 99% (HPLC)
  • L-Phenylalaninamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
  • 5:PN:WO0197794 SEQID:34 claimed protein
  • 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-2-[(4-methyl-2-oxochromen-7-yl)amino]-3-phenylpropanoyl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
  • N-(3-Carboxy-1-oxopropyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-Phenylalaninamide
  • 88467-45-2
  • C34H39N5O9
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Substrates
  • Leucine Aminopeptidase
  • Substrates by Enzyme
  • BioChemical
  • Biochemicals and Reagents
  • Chymotrypsin, alphaEnzyme Substrates
  • Leucine aminopeptidase
  • Leucine AminopeptidaseEnzyme Substrates
  • Enzyme Substrates
  • Protease Substrates
  • Substrates by Enzyme