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Chymotrypsin Substrate II, Fluorogenic

Product Name
Chymotrypsin Substrate II, Fluorogenic
CAS No.
88467-45-2
Chemical Name
Chymotrypsin Substrate II, Fluorogenic
Synonyms
SUC-AAPF-AMC;FACTOR XIIA SUBSTRATE;Z-LYS-PHE-ARG-PNA 2HCL;SUC-ALA-ALA-PRO-PHE-MCA;SUC-ALA-ALA-PRO-PHE-AMC;Z-LYS-PHE-ARG-PNA DIHYDROCHLORIDE;Suc-Ala-Ala-Pro-Phe-AMC≥ 99% (HPLC);FACTOR XIIA SUBSTRATE DIHYDROCHLORIDE;CHYMOTRYPSIN SUBSTRATE II, FLUOROGENIC;5:PN:WO0197794 SEQID:34 claimed protein
CBNumber
CB1701335
Molecular Formula
C34H39N5O9
Formula Weight
661.7
MOL File
88467-45-2.mol
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Chymotrypsin Substrate II, Fluorogenic Property

Boiling point:
1093.0±65.0 °C(Predicted)
Density 
1.347±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Clear, colorless solution (10 mg/mL in Methanol)
form 
White lyophilized solid
pka
4.69±0.10(Predicted)
color 
White to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S9761
Product name
N-Succinyl-Ala-Ala-Pro-Phe-7-amido-4-methylcoumarin
Purity
Leucine aminopeptidase substrate
Packaging
1mg
Price
$94
Updated
2024/03/01
Sigma-Aldrich
Product number
230914
Product name
Chymotrypsin Substrate II, Fluorogenic
Packaging
25mg
Price
$142
Updated
2024/03/01
Sigma-Aldrich
Product number
S9761
Product name
N-Succinyl-Ala-Ala-Pro-Phe-7-amido-4-methylcoumarin
Purity
Leucine aminopeptidase substrate
Packaging
5mg
Price
$315
Updated
2024/03/01
TRC
Product number
C432958
Product name
Chymotrypsin Substrate II, Fluorogenic
Packaging
50mg
Price
$255
Updated
2021/12/16
Chem-Impex
Product number
04643
Product name
Suc-Ala-Ala-Pro-Phe-AMC,99%(HPLC)
Purity
99%(HPLC)
Packaging
50MG
Price
$436.8
Updated
2021/12/16
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Chymotrypsin Substrate II, Fluorogenic Chemical Properties,Usage,Production

Description

Chymotrypsin Substrate II, Fluorogenic finds widespread utility across diverse scientific research applications, encompassing the exploration of protein-protein interactions, enzyme kinetics, and receptor binding. Notably, its cost-effectiveness and user-friendly nature render it an appealing choice for researchers. Additionally, this peptide has been instrumental in delving into the intricate world of cell signaling pathways and unraveling the mechanisms governing gene expression regulation. It is postulated to function as a substrate for enzymes while also engaging with receptors. The prevailing belief suggests that the peptide effectively binds to specific receptors, subsequently triggering their activation and instigating consequential alterations in cellular signaling pathways.

Chemical Properties

White powder

Uses

Chymotrypsin Substrate II, Fluorogenic (cas# 88467-45-2) is a useful compound in organic synthesis and acts as a substrate for chymotrypsin enzyme.

Biological Activity

Sensitive fluorogenic substrate for the quantitative determination of chymotrypsin activity (excitation maximum: ~380 nm; emission maximum: ~460 nm).

References

[1] G B IRVINE C H W M Ennis. Visual detection of peptidase activity using fluorogenic substrates in a microtiter plate assay.[J]. Analytical biochemistry, 1990, 185 2: 304-307. DOI:10.1016/0003-2697(90)90298-n.
[2] LASZLO GRAF. Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin[J]. Biochemistry Biochemistry, 1987, 26 9: 2616-2623. DOI:10.1021/bi00383a031.
[3] OSHIMA G. Interaction of alpha-chymotrypsin with dimyristoyl phosphatidylcholine vesicles.[J]. Journal of biochemistry, 1984, 95 4: 1131-1136. DOI:10.1093/oxfordjournals.jbchem.a134701.
[4] OSHIMA G. Stimulation by phospholipid vesicles of proteolysis of egg white lysozyme by chymotrypsin.[J]. Journal of biochemistry, 1983, 5 1: 1615-1620. DOI:10.1093/OXFORDJOURNALS.JBCHEM.A134509.

Chymotrypsin Substrate II, Fluorogenic Preparation Products And Raw materials

Raw materials

Preparation Products

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Chymotrypsin Substrate II, Fluorogenic Suppliers

China 40 France 1 Germany 2 India 1 Japan 2 Switzerland 1 United Kingdom 2 United States 10 Global 59
CARBONE SCIENTIFIC CO.,LTD
Tel
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Fax
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Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
VWR International
Tel
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Fax
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Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
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View Lastest Price from Chymotrypsin Substrate II, Fluorogenic manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
FACTOR XIIA SUBSTRATE DIHYDROCHLORIDE 88467-45-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-11

88467-45-2, Chymotrypsin Substrate II, FluorogenicRelated Search:

SUC-ALA-GLU-PRO-PHE-AMC SUC-ALA-LEU-PRO-PHE-AMC succinimidyl-alanyl-phenylalanyl-prolyl-phenylalanine 4-nitroanilide SUC-ALA-ALA-PRO-LYS-PNA SUC-ALA-ALA-PRO-ASP-PNA SUC-ALA-ILE-PRO-PHE-PNA SUC-GLY-PHE-GLY-PNA CHYMOTRYPSIN SUBSTRATE I, COLORIMETRIC SUC-ALA-ALA-PRO-VAL-AMC SUC-ALA-PRO-PNA SUC-ALA-PHE-LYS-AMC SUC-PHE-PRO-PHE-PNA SUC-ALA-VAL-PRO-PHE-PNA SUC-ALA-GLU-PRO-PHE-PNA Suc-Phe-Gly-Leu-βNA SUC-PHE-ALA-ALA-PHE-PNA SUC-ALA-ALA-VAL-AMC SUC-ALA-ALA-PRO-NVA-PNA

  • SUCCINYL-L-ALANYL-L-ALANYL-L-PROLYL-L-PHENYLALANINE 4-METHYLCOUMARYL-7-AMIDE
  • SUC-AAPF-AMC
  • SUC-ALA-ALA-PRO-PHE-MCA
  • SUC-ALA-ALA-PRO-PHE-7-AMINO-4-METHYLCOUMARIN
  • SUC-ALA-ALA-PRO-PHE-AMC
  • N-SUCCINYL-ALA-ALA-PRO-PHE 7-AMIDO-4-METHYLCOUMARIN
  • Z-LYS-PHE-ARG-PNA 2HCL
  • Chymotrypsin Substrate II, Fluorogenic - CAS 88467-45-2 - Calbiochem
  • CHYMOTRYPSIN SUBSTRATE II, FLUOROGENIC
  • FACTOR XIIA SUBSTRATE DIHYDROCHLORIDE
  • N-SUCCINYL-ALA-ALA-PRO-PHE 7-AMIDO-4-*ME THYLCOUMARI
  • FACTOR XIIA SUBSTRATE
  • succinylalanylalanyl-prolyl-phenylalanine-4-methylcoumaryl-7-amide
  • Z-LYS-PHE-ARG-PNA DIHYDROCHLORIDE
  • Suc-Ala-Ala-Pro-Phe-AMC≥ 99% (HPLC)
  • L-Phenylalaninamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
  • 5:PN:WO0197794 SEQID:34 claimed protein
  • 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-2-[(4-methyl-2-oxochromen-7-yl)amino]-3-phenylpropanoyl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
  • N-(3-Carboxy-1-oxopropyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-Phenylalaninamide
  • 88467-45-2
  • C34H39N5O9
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Substrates
  • Leucine Aminopeptidase
  • Substrates by Enzyme
  • BioChemical
  • Biochemicals and Reagents
  • Chymotrypsin, alphaEnzyme Substrates
  • Leucine aminopeptidase
  • Leucine AminopeptidaseEnzyme Substrates
  • Enzyme Substrates
  • Protease Substrates
  • Substrates by Enzyme