2,5-BIS-BENZYLOXY-BENZOIC ACID

Product Name: 2,5-BIS-BENZYLOXY-BENZOIC ACID
CAS No.: 67127-91-7
Chemical Name: 2,5-BIS-BENZYLOXY-BENZOIC ACID
Synonyms: 2,5-BIS-BENZYLOXY-BENZOIC ACID;Benzoic acid, 2,5-bis(phenylmethoxy)-
CBNumber: CB1703915
Molecular Formula: C21H18O4
Formula Weight: 334.37
MOL File: 67127-91-7.mol

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2,5-BIS-BENZYLOXY-BENZOIC ACID Property

storage temp.: Sealed in dry,Room Temperature

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 0322AC
Product name: 2,5-Bis(benzyloxy)benzoicacid
Packaging: 1g
Price: $264
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0019640
Product name: 2,5-BIS-BENZYLOXY-BENZOIC ACID
Purity: 95.00%
Packaging: 1G
Price: $1000.52
Updated: 2021/12/16

AK Scientific

Product number: 0322AC
Product name: 2,5-Bis(benzyloxy)benzoicacid
Packaging: 25g
Price: $1776
Updated: 2021/12/16

Ambeed

Product number: A111500
Product name: 2,5-Bis(benzyloxy)benzoicacid
Purity: 98%
Packaging: 25g
Price: $1116
Updated: 2021/12/16

AstaTech

Product number: 37445
Product name: 2,5-BIS-BENZYLOXY-BENZOICACID
Purity: 96%
Packaging: 25/ G
Price: $1260
Updated: 2021/12/16

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2,5-BIS-BENZYLOXY-BENZOIC ACID Chemical Properties,Usage,Production

Synthesis

78283-37-1

67127-91-7

General procedure for the synthesis of 2,5-bis-benzyloxybenzoic acid from the compound (CAS: 78283-37-1): 1.0 g (2.4 mmol) of the ester 25 and 0.19 g (4.7 mmol) of sodium hydroxide were dissolved in 15 mL of a solvent mixture of methanol, dioxane, and water (1:1:1, v/v), and stirred at reflux for 14 hours. After completion of the reaction, it was cooled to 25 °C and most of the organic solvent was removed by rotary evaporator. The residue was diluted with water, acidified with 1N HCl to pH < 7 and subsequently extracted twice with ethyl acetate (50 mL). The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate, and concentrated. The crude product was purified by column chromatography using hexane and ethyl acetate (1:1, v/v) as eluents to afford 0.72 g (91% yield) of the target compound 13.1H NMR (δ, ppm): 11.06 (s, 1H), 7.81 (d, J = 3.1 Hz, 1H), 7.43-7.32 (m, 10H), 7.17 (dd, J = 9.0, 3.1 Hz, 1H), 7.07 (d, J = 9.0 Hz, 1H), 5.26 (s, 2H), 5.08 (s, 2H); 13C NMR (δ, ppm): 165.3, 153.9, 151.9, 136.6, 134.6, 129.4, 129.4, 128.8, 128.4, 128.2, 127.8, 123.0, 119.0, 117.8, 115.1, 73.2, 70.9.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 353 - 356
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 2570 - 2576
[3] Journal of Organic Chemistry, 2004, vol. 69, # 10, p. 3530 - 3537

2,5-BIS-BENZYLOXY-BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2,5-BIS-BENZYLOXY-BENZOIC ACID Suppliers

China 42 Germany 1 India 1 United Kingdom 2 United States 5 Global 51

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2,5-BIS-BENZYLOXY-BENZOIC ACID

Benzoic acid, 2,5-bis(phenylmethoxy)-

67127-91-7

C21H18O4