3-Benzyloxybenzaldehyde
- Product Name
- 3-Benzyloxybenzaldehyde
- CAS No.
- 1700-37-4
- Chemical Name
- 3-Benzyloxybenzaldehyde
- Synonyms
- ASISCHEM N42207;AKOS BBS-00003155;3-Benzyloxybenzaldeh;3-BENZYLOXYBENZALDEHYDE;M-BENZYLOXYBENZALDEHYDE;Metaraminol Impurity 34;3-Benzyloxybenzaldehyde98%;3-Benzyloxybenzaldehyde 98%;3-Benzyloxybenzaldehyde >Benzaldehyde, m-(benzyloxy)-
- CBNumber
- CB5459377
- Molecular Formula
- C14H12O2
- Formula Weight
- 212.24
- MOL File
- 1700-37-4.mol
3-Benzyloxybenzaldehyde Property
- Melting point:
- 56-58 °C(lit.)
- Boiling point:
- 180°C 0,08mm
- Density
- 1.1035 (rough estimate)
- refractive index
- 1.6000 (estimate)
- Flash point:
- 180°C/0.08mm
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Fine Crystalline Powder
- color
- White to light beige
- Water Solubility
- Soluble in water 38.87 mg/L @ 25°C.
- Sensitive
- Air Sensitive
- BRN
- 1956589
- LogP
- 2.960 (est)
- CAS DataBase Reference
- 1700-37-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzyl 3-formylphenyl ether(1700-37-4)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 24/25-36-26
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29124990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B27005
- Product name
- 3-Benzyloxybenzaldehyde
- Purity
- 98%
- Packaging
- 5g
- Price
- $51.4
- Updated
- 2023/01/07
- Product number
- B27005
- Product name
- 3-Benzyloxybenzaldehyde
- Purity
- 98%
- Packaging
- 25g
- Price
- $170
- Updated
- 2023/01/07
- Product number
- B2400
- Product name
- 3-Benzyloxybenzaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $83
- Updated
- 2025/07/31
- Product number
- B285460
- Product name
- 3-Benzyloxybenzaldehyde
- Packaging
- 10g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 2615-1-62
- Product name
- 3-(Benzyloxy)benzaldehyde
- Purity
- 98%
- Packaging
- 100g
- Price
- $188
- Updated
- 2021/12/16
3-Benzyloxybenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
WHITE TO LIGHT BEIGE FINE CRYSTALLINE POWDER
Uses
3-Benzyloxybenzaldehyde is used as a pharmaceutical intermediate. It activates the adenyl cyclase.
Synthesis
100-39-0
100-83-4
1700-37-4
The general procedure for the synthesis of 3-(benzyloxy)benzaldehyde from benzyl bromide and m-hydroxybenzaldehyde was as follows: m-hydroxybenzaldehyde (3 g, 24.6 mmol) and anhydrous potassium carbonate (10.2 g, 73.8 mmol) were suspended in N,N-dimethylformamide (60 mL). Benzyl bromide (3.21 mL, 27.1 mmol) was added dropwise to this suspension and the reaction was stirred at room temperature for 14 hours. Upon completion of the reaction, the reaction mixture was poured into a mixture of ethyl acetate and water for liquid-liquid partitioning. The organic phase was separated, washed three times with water, the organic phase was dried with anhydrous magnesium sulfate, and the desiccant was removed by filtration. The filtrate was concentrated under reduced pressure and the resulting crude product was purified by silica gel column chromatography with an eluent ratio of heptane:ethyl acetate (4:1 to 1:1 gradient elution) to afford the target compound 3-(benzyloxy)benzaldehyde (5.16 g, 99% yield). The product was characterized by 1H-NMR (CDCl3) with the following chemical shift δ (ppm): 5.13 (2H, s, -OCH2-), 7.24-7.25 (1H, m, aryl ring H), 7.35-7.49 (8H, m, aryl ring H), 9.98 (1H, s, -CHO).
References
[1] Journal of the American Chemical Society, 1994, vol. 116, # 18, p. 8402 - 8403
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 7, p. 3188 - 3208
[3] Patent: US2007/105904, 2007, A1. Location in patent: Page/Page column 112
[4] Molecules, 2010, vol. 15, # 11, p. 7971 - 7984
[5] Journal of the American Chemical Society, 2001, vol. 123, # 22, p. 5382 - 5383
3-Benzyloxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Benzyloxybenzaldehyde manufacturers
- Product
- 3-Benzyloxybenzaldehyde 1700-37-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-15
- Product
- 3-Benzyloxybenzaldehyde 1700-37-4
- Price
- US $5.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-08-05