2,3,4-Trimethoxybenzaldehyde
- Product Name
- 2,3,4-Trimethoxybenzaldehyde
- CAS No.
- 2103-57-3
- Chemical Name
- 2,3,4-Trimethoxybenzaldehyde
- Synonyms
- TriMetazidine EP IMpurity-C;Benzaldehyde, 2,3,4-trimethoxy-;2,3,4-TMB;AKOS BBS-00003174;2,3,4-TrimethoxybenzaL;Trimetazidine Impurity C;4-TriMethoxybenzaldehyde;trimetazidine impurity1139;2,3,4-Trimetoxybenzaldehyde;Trimetazidine intermediate
- CBNumber
- CB9260504
- Molecular Formula
- C10H12O4
- Formula Weight
- 196.2
- MOL File
- 2103-57-3.mol
2,3,4-Trimethoxybenzaldehyde Property
- Melting point:
- 38-40 °C(lit.)
- Boiling point:
- 168-170 °C12 mm Hg(lit.)
- Density
- 1.2166 (rough estimate)
- refractive index
- n20/D 1.5547(lit.)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- methanol: 0.1 g/mL, clear
- form
- Crystals or Crystalline Powder
- color
- White to light yellow
- Sensitive
- Air Sensitive
- BRN
- 981091
- InChI
- InChI=1S/C10H12O4/c1-12-8-5-4-7(6-11)9(13-2)10(8)14-3/h4-6H,1-3H3
- InChIKey
- UCTUXUGXIFRVGX-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=C(OC)C(OC)=C1OC
- CAS DataBase Reference
- 2103-57-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzaldehyde, 2,3,4-trimethoxy-(2103-57-3)
- EPA Substance Registry System
- Benzaldehyde, 2,3,4-trimethoxy- (2103-57-3)
Safety
- Hazard Codes
- Xi,C
- Risk Statements
- 36/37/38-34
- Safety Statements
- 22-24/25-45-36/37/39-27-26
- WGK Germany
- 3
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29124900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 152099
- Product name
- 2,3,4-Trimethoxybenzaldehyde
- Purity
- 99%
- Packaging
- 10g
- Price
- $34.3
- Updated
- 2025/07/31
- Product number
- 152099
- Product name
- 2,3,4-Trimethoxybenzaldehyde
- Purity
- 99%
- Packaging
- 50g
- Price
- $111
- Updated
- 2025/07/31
- Product number
- T1101
- Product name
- 2,3,4-Trimethoxybenzaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $63
- Updated
- 2025/07/31
- Product number
- T795685
- Product name
- 2,3,4-Trimethoxybenzaldehyde
- Packaging
- 100g
- Price
- $215
- Updated
- 2021/12/16
- Product number
- T795685
- Product name
- 2,3,4-Trimethoxybenzaldehyde
- Packaging
- 25g
- Price
- $85
- Updated
- 2021/12/16
2,3,4-Trimethoxybenzaldehyde Chemical Properties,Usage,Production
Description
2,3,4-Trimethoxybenzaldehyde is a white crystalline powder, and the chemical formula is C 10H 12O 4; the molecular weight is 196.2; the fusing point is 38-40 degrees, and is a kind of important medicine intermediate; it is mainly used in new type drug Ca2+ Synthesizing of channel blocker. The alternative cerebral arteries that are used for this medicine reduce the headache incidence, mainly for the preparation of the intermediate of trimetazidine.
Synthesis
A coking gallic acid is utilized as a raw material, and dimethyl sulfate is utilized as an alkylate reagent; under the condition of the existence of sodium hydroxide, methylation is performed through an O-alkylation reaction to obtain an intermediate 1, 2, 3-trimethoxybenzene. After that, the 1,2, 3-trimethoxybenzene and a Vilsmeier-Haack reagent are subjected to a formylation reaction to get the 2,3,4-Trimethoxybenzaldehyde.
Chemical Properties
white to light yellow crystals or cryst. powder
Uses
2,3,4-Trimethoxybenzaldehyde is a trimethoxylated aromatic aldehyde. 2,3,4-Trimethoxybenzaldehyde is an Impurity of the anti-anginal drug Trimetazidine (T795610).
Uses
2,3,4-Trimethoxybenzaldehyde was used to study the effects of 2,3,4-trimethoxybenzaldehyde on tubulin-dependent GTP hydrolysis.
References
[1] Organic and Biomolecular Chemistry, 2014, vol. 12, # 22, p. 3721 - 3734
[2] Molecules, 2015, vol. 20, # 5, p. 9229 - 9241
[3] Justus Liebigs Annalen der Chemie, 1972, vol. 763, p. 109 - 120
2,3,4-Trimethoxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3,4-Trimethoxybenzaldehyde manufacturers
- Product
- 2,3,4-Trimethoxybenzaldehyde 2103-57-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-27
- Product
- 2,3,4-Trimethoxybenzaldehyde 2103-57-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28
- Product
- 2,3,4-Trimethoxy Benzaldehyde 2103-57-3
- Price
- US $1.00/KG
- Min. Order
- 100KG
- Purity
- 99%MIN.
- Supply Ability
- 100MT/Year
- Release date
- 2022-08-17