ChemicalBook > CAS DataBase List > Trimethyl phosphite

Trimethyl phosphite

Product Name
Trimethyl phosphite
CAS No.
121-45-9
Chemical Name
Trimethyl phosphite
Synonyms
P(OMe)3;P(OCH3)3;AURORA KA-1230;Trimethylfosfit;Trimethoxyfosfin;METHYL PHOSPHITE;TrimethyPhosphite;Trimethylphosphit ;TRIMETHYL PHOSPHITE;TRIMETHYLPHOSPHIT S
CBNumber
CB7100684
Molecular Formula
C3H9O3P
Formula Weight
124.08
MOL File
121-45-9.mol
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Trimethyl phosphite Property

Melting point:
−78 °C(lit.)
Boiling point:
111-112 °C(lit.)
Density 
1.052 g/mL at 25 °C(lit.)
vapor density 
4.3 (vs air)
vapor pressure 
17 mm Hg ( 20 °C)
refractive index 
n20/D 1.408(lit.)
Flash point:
82 °F
storage temp. 
2-8°C
form 
Liquid
color 
Colorless
Specific Gravity
1.052
explosive limit
5.2-61.2%(V)
Water Solubility 
Hydrolyzes with water.
Sensitive 
Air & Moisture Sensitive
Hydrolytic Sensitivity
4: no reaction with water under neutral conditions
BRN 
956570
Exposure limits
TLV-TWA 10 mg/m3 (2 ppm) (ACGIH).
CAS DataBase Reference
121-45-9(CAS DataBase Reference)
NIST Chemistry Reference
Phosphorous acid, trimethyl ester(121-45-9)
EPA Substance Registry System
Trimethyl phosphite (121-45-9)
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Safety

Hazard Codes 
Xn,T,F,Xi
Risk Statements 
10-22-36/37/38-41-37/38-65-48/23/24/25-11-46-45-67-66-36
Safety Statements 
26-39-62-45-16-53
RIDADR 
UN 2329 3/PG 3
WGK Germany 
1
RTECS 
TH1400000
10-13-21
Autoignition Temperature
250 °C
TSCA 
Yes
HS Code 
2920 23 00
HazardClass 
3
PackingGroup 
III
Hazardous Substances Data
121-45-9(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 1600 mg/kg LD50 dermal Rabbit 2600 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H313May be harmful in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

H341Suspected of causing genetic defects

H351Suspected of causing cancer

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.00553
Product name
Trimethyl phosphite
Purity
for synthesis
Packaging
100 mL
Price
$35.61
Updated
2021/03/22
Sigma-Aldrich
Product number
240907
Product name
Trimethyl phosphite
Purity
≥99%
Packaging
25g
Price
$35.8
Updated
2021/03/22
Sigma-Aldrich
Product number
8.00553
Product name
Trimethyl phosphite
Purity
for synthesis
Packaging
500 mL
Price
$127.65
Updated
2021/03/22
Sigma-Aldrich
Product number
240907
Product name
Trimethyl phosphite
Purity
≥99%
Packaging
100g
Price
$85.4
Updated
2021/03/22
Alfa Aesar
Product number
030132
Product name
Trimethyl phosphite
Purity
97%
Packaging
500g
Price
$136
Updated
2021/03/22
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Trimethyl phosphite Chemical Properties,Usage,Production

Chemical Properties

Trimethyl phosphite is a colorless liquid. Distinctive pungent, pyridine-like odor. The Odor Threshold is 0.0001 ppm.

Uses

Chemical intermediate, especially for insecticides.

Uses

Trimethyl phosphite is used in the manufacture of pesticides and fire retardants..

Uses

Used primarily in the synthesis of organophosphate insecticides; also used in the production of flame-retardant polymers and textiles.

Production Methods

Produced via a reaction between phosphorus trichloride and methanol in the presence of a tertiary amine catalyst such as diethylaniline.

General Description

A clear colorless liquid with a strong foul odor. Flash point 99°F. Denser than water and insoluble in waterwater; soluble in hexane, benzene, acetone, alcohol, ether, carbon tetrachloride, and kerosene.. Vapors heavier than air. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Insoluble in water and denser than water. Slowly reacts with water to form phosphoric acid and corresponding organic alcohol.

Reactivity Profile

As soon as Trimethyl phosphite contacted a small amount of magnesium perchlorate in a flask, there was a flash and an explosion that shattered the flask (Allison 1968).

Health Hazard

Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.

Health Hazard

Trimethyl phosphite is a skin, eye, and mucous membrane irritant with low subacute inhalation toxicity. Its irritating action on rabbits’ skin was moderate to severe. The pure liquid instilled into the eyes can cause severe irritation and swelling, which can last for a few days. Chronic exposure to 300–600 ppm concentration in air produced lung inflammation and cataracts in mice. There was no acute inhalation toxicity observed in test animals. The oral and dermal toxicities were low.
LD50 value, oral (rats): 1600 mg/kg
Teratogenic effects showing gross abnormalities were observed in newborn rats when pregnant rats were dosed with high concentrations of trimethyl phosphite.
The odor threshold for this compound was determined to be 0.0001 ppm (ACGIH 1986). The odor is irritating and pungent at high concentrations..

Fire Hazard

Special Hazards of Combustion Products: Toxic fumes of PO x

Safety Profile

Moderately toxic by ingestion and skin contact. An experimental teratogen. A severe skin and eye irritant. Flammable liquid when exposed to heat, flame, or oxidizers. To fight fire, use water, foam, fog, CO2. Violent explosive reaction on contact with magnesium perchlorate or trimethyl platinum(IV) azide tetramer. When heated to decomposition it emits toxic fumes of POx. An intermediate in the production of pesticides, fire retardants, and organic phosphorus additives. See also ESTERS.

Potential Exposure

Trimethyl phosphite is a flame retardant, and used as an intermediate in the manufacture of a number of pesticides, and organophosphorus additives.

Carcinogenicity

Trimethyl phosphite was genotoxic in mouse lymphoma assays but was not mutagenic in various bacterial assays.

Shipping

UN2329 Trimethyl phosphite, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

Treat the phosphite with Na (to remove water and any dialkyl phosphonate), then decant and distil it with protection against moisture. It has also been treated with sodium wire for 24hours, then distilled in an inert atmosphere onto activated molecular sieves [Connor et al. J Chem Soc, Dalton Trans 511 1986]. It can be fractionally distilled using a spinning band column at high reflux ratio. It is a colourless liquid which is slowly hydrolysed by H2O. [Gillis et al. J Am Chem Soc 80 2999 1958, NMR: Callis et al. J Am Chem Soc 79 2719 1957, Kosolapoff Organophosphorus Compounds, Wiley p 203 1950, Beilstein 1 IV 1256.]

Incompatibilities

Vaor May form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Violent reaction with magnesium perchlorate. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Reacts (hydrolyzes) with water. Incompatible with air, moisture.

Waste Disposal

Trimethyl phosphite may be burned in a chemical incinerator equipped with an afterburner and scrubber.

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Trimethyl phosphite Suppliers

Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 qq:2355568890
Fax
0086-21-50182339
Email
sales@demochem.com; export1@demochem.com
Country
China
ProdList
2582
Advantage
57
Beijing dtftchem Technology Co., Ltd.
Tel
13651141086; 86(10)60275028、60275820
Fax
86 (10) 60270825
Email
dtftchem@sina.com
Country
China
ProdList
3392
Advantage
62
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43503
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028-
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12356
Advantage
60
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
;021-54306202- ;
Email
jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com
Country
China
ProdList
43253
Advantage
64
Chengdu XiYa Chemical Technology Co., Ltd.
Tel
;
Fax
0539-6365991
Email
sale@xiyashiji.com;3007716753@qq.com
Country
China
ProdList
10578
Advantage
57
Syntechem Co.,Ltd
Tel
Please Email
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
13009
Advantage
57
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View Lastest Price from Trimethyl phosphite manufacturers

Hebei Zhanyao Biotechnology Co. Ltd
Product
Trimethyl Phosphite 121-45-9
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-08
Hebei Zhanyao Biotechnology Co. Ltd
Product
Trimethyl Phosphite 121-45-9
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-05
Hebei Guanlang Biotechnology Co., Ltd.
Product
Trimethyl phosphite 121-45-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2021-09-27

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