description Chemical properties uses
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Trimethyl phosphate

description Chemical properties uses
Product Name
Trimethyl phosphate
CAS No.
512-56-1
Chemical Name
Trimethyl phosphate
Synonyms
TMP;(CH3O)3PO;NCI-C03781;TriMethylphosp;Trimethylfosfat;METHYL PHOSPHATE;(Lactic acid) TMP;rimethylphosphate;TRIMETHYL PHOSPHATE;Trimethyl phsophate
CBNumber
CB2853709
Molecular Formula
C3H9O4P
Formula Weight
140.07
MOL File
512-56-1.mol
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Trimethyl phosphate Property

Melting point:
-46 °C (lit.)
Boiling point:
197 °C (lit.)
Density 
1.197 g/mL at 25 °C (lit.)
vapor pressure 
1.133 hPa (25 °C)
refractive index 
n20/D 1.395(lit.)
Flash point:
107 °C
storage temp. 
Store below +30°C.
solubility 
1000g/l
form 
Liquid
color 
Clear
Specific Gravity
1.197
Water Solubility 
500 G/L (25 ºC)
Sensitive 
Moisture Sensitive
BRN 
1071731
InChIKey
WVLBCYQITXONBZ-UHFFFAOYSA-N
CAS DataBase Reference
512-56-1(CAS DataBase Reference)
NIST Chemistry Reference
Phosphoric acid, trimethyl ester(512-56-1)
EPA Substance Registry System
Trimethyl phosphate (512-56-1)
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Safety

Hazard Codes 
T,Xn,Xi
Risk Statements 
46-22-40-68-45-20/21/22-38-36
Safety Statements 
53-36/37-45-36/37/39-26
RIDADR 
2810
WGK Germany 
1
RTECS 
TC8225000
21
Hazard Note 
Toxic/Moisture Sensitive
TSCA 
Yes
HS Code 
2919 90 00
Hazardous Substances Data
512-56-1(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 840 mg/kg LD50 dermal Rabbit 3388 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H340May cause genetic defects

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P281Use personal protective equipment as required.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.21184
Product name
Trimethyl phosphate
Purity
for synthesis
Packaging
100 mL
Price
$31.08
Updated
2021/12/16
Sigma-Aldrich
Product number
132195
Product name
Trimethyl phosphate
Purity
97%
Packaging
250g
Price
$42.8
Updated
2021/12/16
Sigma-Aldrich
Product number
8.21184
Product name
Trimethyl phosphate
Purity
for synthesis
Packaging
500 mL
Price
$62.44
Updated
2021/12/16
Sigma-Aldrich
Product number
132195
Product name
Trimethyl phosphate
Purity
97%
Packaging
1kg
Price
$119
Updated
2021/12/16
Sigma-Aldrich
Product number
8.21184
Product name
Trimethyl phosphate
Purity
for synthesis
Packaging
2.5 L
Price
$234.02
Updated
2021/12/16
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Trimethyl phosphate Chemical Properties,Usage,Production

description

Trimethyl phosphate (TMP) is a kind of organic reagent, stable at room temperature, good solubility in a variety of resins, low viscosity, low hue, so it can be used as special solvents; such as epoxy resin additives (reduced viscosity); anti stain when processing polyester fiber (To improve the dyeing quality); textile finishing agent; used as gasoline additives, can prevent the detonation, improve the octane number, increase the stability of lead-based gasoline storage; can also be used as a control agent for gasoline surface ignition, tetraethyllead decomposition inhibitor when high temperature; non-corrosive gasoline additive; catalyst for polymerization of polyester fiber; modifier for graphite product; plasticizer; extraction agent; pesticide raw material for pesticide. Trimethyl phosphate hydrolysis occurs in water, so it is necessary to preserve moisture. Because of its hydrolysis and the release of PO43-, thus becoming the homogeneous precipitation agent, which is insoluble phosphate precipitation, is often used as precipitation reagents of zirconium and hafnium and a diffusion source for the determination of semiconductors. In addition, trimethyl phosphate is also a phospholipid extractant for the extraction and separation of certain metal ions.

Chemical properties

Trimethyl phosphate is a colorless transparent liquid, soluble in water, soluble in ether, but insoluble in ethanol.

uses

(1) Trimethyl phosphate used as a reagent for determination of zirconium, solvent, extractant and gas chromatography stationary phase.
(2) It is mainly used as medicine and solvent and extraction agent of pesticide. Pesticide intermediates. In Japan, mainly used for textile oil and anti-coloring agent of polymer.
(3) It is used as gas chromatography stationary phase; for the determination of zirconium; used as extraction agent.

Chemical Properties

Colorless liquid; bp 197°C (386°F); density 1.197 at 20°C (68 °F); soluble in most organic solvents, low solubility in water.

Uses

TMP is used as an intermediate in organic synthesis. Its industrial applications are much fewer than those of other organic phosphates.

Uses

For controlling spark plug fouling, surface ignition and rumble in gasoline engines.

Uses

Trimethyl Phosphate is used as an electrolyte additive in the synthesis of lithium ion batteries.

Production Methods

Prepared by the reaction of phosphorus oxychloride with methanol.

Definition

ChEBI: A trialkyl phosphate that is the trimethyl ester of phosphoric acid.

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 3178, 1974 DOI: 10.1021/jo00935a041
Tetrahedron Letters, 28, p. 2981, 1987 DOI: 10.1016/S0040-4039(00)96262-2

General Description

A pale straw colored liquid. Inhalation may irritate or seriously burn respiratory tract. vapor or liquid may irritate or severely burn skin or eyes. Ingestion may irritate or burn the mucous membranes of the gastrointestinal tract.

Reactivity Profile

TRIMETHYL PHOSPHATE may explode when heated. Residue from a large scale atmospheric pressure distillation of Trimethyl phosphate has exploded violently. Trimethyl phosphate is incompatible with nitrates. . Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Hazard

Toxic by ingestion and inhalation, strong irritant to skin and eyes.

Health Hazard

There are no reports on the toxicity of trimethyl phosphate to humans.

Health Hazard

TMP is a mutagen, teratogen, and a cancercausing compound. The health hazard from this compound is somewhat different from those of the higher members of the organic phosphate series. While carcinogenicity is observed only for this phosphate, with mutagenicity and the teratogenic effects being more marked, higher alkyl phosphates are more neurotoxic but noncarcinogenic.
TMP is toxic at high dosages.LD50 value,oral(mice):1470 mg/kg(NIOSH 1986)
Laboratory tests on animals indicated clear evidence of its cancer-causing actions, producing uterine and skin tumors. There is so far no report on such carcinogenic actions in humans. The compound tested positive in mutagenic tests and caused fetal deaths and birth defects in mice, rats, and hamsters when given orally or intraperitoneally..

Fire Hazard

Trimethyl phosphate is nonflammable.

Industrial uses

1 Gasoline additive at 0.25 g/gal for controlling surface ignition and spark plug fouling.
2 Methylating agent, chemical intermediate in the production of polymethyl polyphosphates.
3 Flame retardant solvent for paints and polymers.
4 Catalyst in the preparation of polymers and resins.

Safety Profile

Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by ingestion, skin contact, intraperitoneal, and intravenous routes. Experimental reproductive effects. Human mutation data reported. Explodes when heat distilled. When heated to decomposition it emits toxic fumes of POx. See also ESTERS.

Metabolism

A system utilizing isolated anterior forearm stratum corneum conjunctum of man to study skin penetrating capacity of a series of organic phosphates was developed. Trimethyl phosphate was tested in the system and had the greatest skin-penetrating capacity of the 8 related compounds tested (Marzulli et al 1965).
Rats treated orally at 100 mg/kg and mice treated i.p. at 1000 mg/kg with [32]P-labeled trimethyl phosphate excreted primarily dimethyl phosphate in the urine. Only traces of the parent compound were detected, and only in the rats at less than 6 h after treatment. S-Methyl cysteine and S-methyl cysteine N-acetate were also isolated. Small amounts of S-methyl glutathione were detected, presumably the initial methylation product in this series of metabolites (Jones 1970). Metabolism of trimethyl phosphate was faster in the mouse than in the rat, but there was no evidence of further conversion to monomethyl phosphate or inorganic phosphate in either species (Jackson and Jones 1968).

Purification Methods

Purify the phosphate by fractionation through an efficient column at high reflux ratio. It is quite soluble in H2O; the solubility is 1:1 at 25o. [Becker J Am Chem Soc 74 2923 1952, IR: Bergmann et al. J Chem Soc 847 1952, McIvor et al. Can J Chem 36 820 1958, Kosolapoff Organophosphorus Compounds, Wiley p 258 1950, and Cherbuliez in Organo Phosphorus Compounds (Kosolapoff & Maier eds) Wiley Vol 6 pp 211-577 1973, Beilstein 1 IV 1259.]

Waste Disposal

TMP is mixed with a combustible solvent and destroyed by burning in a chemical incinerator.

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Trimethyl phosphate Suppliers

Zhang Jia Gang YaRui Chemical co.,Ltd
Tel
0512-58961066
Fax
86-0512-58961068
Email
sales@yaruichem.com
Country
China
ProdList
35
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64
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-62063333-1
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24980
Advantage
65
Zhangjiagang create Material Co., Ltd.
Tel
0512-58361933
Fax
0512-58662200
Email
2624018324@qq.com
Country
China
ProdList
22
Advantage
58
ZhangJiaGang YaRui Chemical Co.,Ltd.
Tel
0512-58961066-
Fax
0512-58961068
Email
sales@yaruichem.com
Country
China
ProdList
40
Advantage
62
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
+86-021-61259100
Fax
86-21-61259102
Email
int02@meryer.com
Country
China
ProdList
40264
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 qq:2355568890
Fax
0086-21-50182339
Email
sales@demochem.com; export1@demochem.com
Country
China
ProdList
2582
Advantage
57
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View Lastest Price from Trimethyl phosphate manufacturers

Wuhan Mulei New Material Technology Co. Ltd
Product
Trimethyl phosphate 512-56-1
Price
US $10.00/KG/Tin
Min. Order
1KG
Purity
99%
Supply Ability
5000tons per month
Release date
2021-04-02
Hebei Crovell Biotech Co Ltd
Product
Trimethyl Phosphate 512-56-1
Price
US $15.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
50 ton
Release date
2021-07-06
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Trimethyl phosphate 512-56-1
Price
US $0.00-0.00/Kg/Drum
Min. Order
25KG
Purity
99%GC
Supply Ability
10 TONS
Release date
2021-06-17

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