Trimethyl phosphate
- Product Name
- Trimethyl phosphate
- CAS No.
- 512-56-1
- Chemical Name
- Trimethyl phosphate
- Synonyms
- TMP;METHYL PHOSPHATE;(CH3O)3PO;Trimethyl phosphate(Trimethoxyphosphine oxide,Trimethyl orthophosphate);zCCCCFYZX;NCI-C03781;TriMethylphosp;Trimethylfosfat;(Lactic acid) TMP;rimethylphosphate
- CBNumber
- CB2853709
- Molecular Formula
- C3H9O4P
- Formula Weight
- 140.07
- MOL File
- 512-56-1.mol
Trimethyl phosphate Property
- Melting point:
- -46 °C (lit.)
- Boiling point:
- 197 °C (lit.)
- Density
- 1.197 g/mL at 25 °C (lit.)
- vapor pressure
- 1.133 hPa (25 °C)
- refractive index
- n20/D 1.395(lit.)
- Flash point:
- 107 °C
- storage temp.
- Store below +30°C.
- solubility
- 1000g/l
- form
- Liquid
- color
- Clear
- Specific Gravity
- 1.197
- Water Solubility
- 500 G/L (25 ºC)
- Sensitive
- Moisture Sensitive
- BRN
- 1071731
- Dielectric constant
- 21.260000000000002
- InChIKey
- WVLBCYQITXONBZ-UHFFFAOYSA-N
- LogP
- -0.46 at 25℃
- CAS DataBase Reference
- 512-56-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Phosphoric acid, trimethyl ester(512-56-1)
- EPA Substance Registry System
- Trimethyl phosphate (512-56-1)
Safety
- Hazard Codes
- T,Xn,Xi
- Risk Statements
- 46-22-40-68-45-20/21/22-38-36
- Safety Statements
- 53-36/37-45-36/37/39-26
- RIDADR
- 2810
- WGK Germany
- 1
- RTECS
- TC8225000
- F
- 21
- Hazard Note
- Toxic/Moisture Sensitive
- TSCA
- Yes
- HS Code
- 2919 90 00
- Hazardous Substances Data
- 512-56-1(Hazardous Substances Data)
- Toxicity
- LD50 orally in Rabbit: 840 mg/kg LD50 dermal Rabbit 3388 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H340May cause genetic defects
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 8.21184
- Product name
- Trimethyl phosphate
- Purity
- for synthesis
- Packaging
- 100mL
- Price
- $41
- Updated
- 2024/03/01
- Product number
- 8.21184
- Product name
- Trimethyl phosphate
- Purity
- for synthesis
- Packaging
- 500mL
- Price
- $82.4
- Updated
- 2024/03/01
- Product number
- 8.21184
- Product name
- Trimethyl phosphate
- Purity
- for synthesis
- Packaging
- 2.5L
- Price
- $294
- Updated
- 2024/03/01
- Product number
- 132195
- Product name
- Trimethyl phosphate
- Purity
- 97%
- Packaging
- 250g
- Price
- $56.7
- Updated
- 2024/03/01
- Product number
- 132195
- Product name
- Trimethyl phosphate
- Purity
- 97%
- Packaging
- 1kg
- Price
- $215
- Updated
- 2024/03/01
Trimethyl phosphate Chemical Properties,Usage,Production
Chemical Properties
Trimethyl phosphate (TMP), the simplest trialkyl ester of phosphoric acid, It is a colourless, nonvolatile liquid. soluble in most organic solvents, low solubility in water. TMP is stable in neutral, acidic or alkaline solutions, and is classified as "not readily biodegradable". Direct photodegradation is not expected because trimethyl phosphate does not absorb UV light.
Uses
Trimethyl phosphate is used as an intermediate in organic synthesis. Its industrial applications are much fewer than those of other organic phosphates.Trimethyl phosphate undergoes hydrolysis in contact with water, so it should be stored in a moisture-proof manner. Due to its hydrolysis and release of PO43-, thus becoming a homogeneous precipitant for the formation of insoluble phosphate precipitation, often used as a precipitation reagent for zirconium and hafnium and as a diffusion source for the determination of semiconductors. In addition, trimethyl phosphate is also a phospholipid extractant for the extraction and separation of certain metal ions.
Uses
Trimethyl Phosphate is used as an electrolyte additive in the synthesis of lithium ion batteries. for controlling spark plug fouling, surface ignition and rumble in gasoline engines.
Trimethyl phosphate used as a reagent for determination of zirconium, solvent, extractant and gas chromatography stationary phase.
Definition
ChEBI: Trimethyl phosphate is a trialkyl phosphate that is the trimethyl ester of phosphoric acid. It has a role as an insect attractant.
Production Methods
Trimethyl phosphate is prepared by treating phosphorus oxychloride with methanol in the presence of an amine base:
POCl3 + 3 CH3OH + 3 R3N → PO(OCH3)3 + 3 R3NH+Cl
It is a tetrahedral molecule that is a weakly polar solvent.
Synthesis Reference(s)
The Journal of Organic Chemistry, 39, p. 3178, 1974 DOI: 10.1021/jo00935a041
Tetrahedron Letters, 28, p. 2981, 1987 DOI: 10.1016/S0040-4039(00)96262-2
General Description
Trimethyl phosphate appears as a pale straw colored liquid. Inhalation may irritate respiratory tract. Vapor or liquid may irritate skin or eyes. Ingestion may irritate the mucous membranes of the gastrointestinal tract.
Reactivity Profile
TRIMETHYL PHOSPHATE may explode when heated. Residue from a large scale atmospheric pressure distillation of Trimethyl phosphate has exploded violently. Trimethyl phosphate is incompatible with nitrates. . Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Hazard
Toxic by ingestion and inhalation, strong irritant to skin and eyes. trimethyl phosphate (TMP) is absorbed rapidly and completely by inhalation of its vapour, through the skin and by ingestion (WHO).
Health Hazard
Trimethyl phosphate (TMP) is a mutagen, teratogen, and a cancercausing compound. The health hazard from this compound is somewhat different from those of the higher members of the organic phosphate series. While carcinogenicity is observed only for this phosphate, with mutagenicity and the teratogenic effects being more marked, higher alkyl phosphates are more neurotoxic but noncarcinogenic.
TMP is toxic at high dosages.LD50 value,oral(mice):1470 mg/kg(NIOSH 1986)
Laboratory tests on animals indicated clear evidence of its cancer-causing actions, producing uterine and skin tumors. There is so far no report on such carcinogenic actions in humans. The compound tested positive in mutagenic tests and caused fetal deaths and birth defects in mice, rats, and hamsters when given orally or intraperitoneally.
Fire Hazard
Trimethyl phosphate is nonflammable.
Flammability and Explosibility
Not classified
Industrial uses
1 Gasoline additive at 0.25 g/gal for controlling surface ignition and spark plug
fouling.
2 Methylating agent, chemical intermediate in the production of polymethyl
polyphosphates.
3 Flame retardant solvent for paints and polymers.
4 Catalyst in the preparation of polymers and resins.
Safety Profile
Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by ingestion, skin contact, intraperitoneal, and intravenous routes. Experimental reproductive effects. Human mutation data reported. Explodes when heat distilled. When heated to decomposition it emits toxic fumes of POx. See also ESTERS.
Metabolism
A system utilizing isolated anterior forearm stratum corneum conjunctum of man
to study skin penetrating capacity of a series of organic phosphates was developed.
Trimethyl phosphate was tested in the system and had the greatest skin-penetrating
capacity of the 8 related compounds tested (Marzulli et al 1965).
Rats treated orally at 100 mg/kg and mice treated i.p. at 1000 mg/kg with
[32]P-labeled trimethyl phosphate excreted primarily dimethyl phosphate in the
urine. Only traces of the parent compound were detected, and only in the rats at
less than 6 h after treatment. S-Methyl cysteine and S-methyl cysteine N-acetate
were also isolated. Small amounts of S-methyl glutathione were detected, presumably
the initial methylation product in this series of metabolites (Jones 1970).
Metabolism of trimethyl phosphate was faster in the mouse than in the rat, but
there was no evidence of further conversion to monomethyl phosphate or inorganic
phosphate in either species (Jackson and Jones 1968).
Purification Methods
Purify the phosphate by fractionation through an efficient column at high reflux ratio. It is quite soluble in H2O; the solubility is 1:1 at 25o. [Becker J Am Chem Soc 74 2923 1952, IR: Bergmann et al. J Chem Soc 847 1952, McIvor et al. Can J Chem 36 820 1958, Kosolapoff Organophosphorus Compounds, Wiley p 258 1950, and Cherbuliez in Organo Phosphorus Compounds (Kosolapoff & Maier eds) Wiley Vol 6 pp 211-577 1973, Beilstein 1 IV 1259.]
Waste Disposal
TMP is mixed with a combustible solvent and destroyed by burning in a chemical incinerator.
Trimethyl phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Trimethyl phosphate manufacturers
- Product
- Trimethyl phosphate 512-56-1
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-14
- Product
- Trimethyl phosphate 512-56-1
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 25KG
- Purity
- 99%GC
- Supply Ability
- 10 TONS
- Release date
- 2021-06-17
- Product
- Trimethyl phosphate 512-56-1
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99.5%
- Supply Ability
- 100 TON
- Release date
- 2024-10-31