6-Methylisoquinoline
- Product Name
- 6-Methylisoquinoline
- CAS No.
- 42398-73-2
- Chemical Name
- 6-Methylisoquinoline
- Synonyms
- 6-Methylisoquinoline;Isoquinoline, 6-methyl-;6-Methylisoquinoline 98%;6-Methylisoquinoline ,98%;3,4,4-trimethylpentan-2-one;6-Methylisoquinoline ISO 9001：2015 REACH
- CBNumber
- CB5879955
- Molecular Formula
- C10H9N
- Formula Weight
- 143.19
- MOL File
- 42398-73-2.mol
6-Methylisoquinoline Property
- Melting point:
- 85.5°C
- Boiling point:
- 246.29°C (estimate)
- Density
- 1.0584 (estimate)
- refractive index
- 1.6103 (estimate)
- pka
- 5.85±0.10(Predicted)
- form
- solid
- color
- Beige
- CAS DataBase Reference
- 42398-73-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M321770
- Product name
- 6-Methylisoquinoline
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR8565
- Product name
- 6-Methylisoquinoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $82
- Updated
- 2021/12/16
- Product number
- OR8565
- Product name
- 6-Methylisoquinoline
- Purity
- 98%
- Packaging
- 5g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- Y9087
- Product name
- 6-Methylisoquinoline
- Packaging
- 25g
- Price
- $477
- Updated
- 2021/12/16
- Product number
- CHM0027846
- Product name
- 6-METHYLISOQUINOLINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $657.54
- Updated
- 2021/12/16
6-Methylisoquinoline Chemical Properties,Usage,Production
Chemical Properties
Light beige powder
Uses
6-Methylisoquinoline (cas# 42398-73-2) is a useful reagent for the green preparation of polyfluoroarylated heterocyclic compounds.
Preparation
A benzene solution (50 ml, CAUTION) of equimolar amounts of p-tolualdehyde (8.4 g, 0.07 mol) and aminoacetaldehyde dimethyl acetal (7.35 g, 0.07 mol) is refluxed overnight into a Dean and Stark trap. The solution is evaporated in vacuo and then twice evaporated again with added benzene and the viscous oil dissolved in dry tetrahydrofuran. This solution is cooled to - 10 °C and 1 equivalent of ethyl chloroformate (7. 1 ml, 0.07 mol) is added with rapid stirring and the mixture stirred for a further 5 minutes. The cooling bath is removed and 1.2 equivalents of trimethyl phosphite ( 10.5 ml, 0.09 mol) is added with stirring. The solution is stirred at room temperature for 1 5 hours and then evaporated t o an oil. The oil is then re-evaporated twice with added toluene to remove traces of trimethyl phosphite. The oil is dissolved in dry dichloromethane, 6 equivalents of titanium(1v) chloride (50 ml, 0.45 mol) is added and the solution refluxed for 36 hours under a drying tube. The cooled solution is shaken with 1 equivalent of aqueous sodium hydroxide solution to neutrality, whereupon titanium(1v) oxide precipitates as a white solid. The filtered organic layer is extracted with 3 M hydrochloric acid, and the extract is washed with dichloromethane, basified strongly with aqueous alkali, and extracted with dichloromethane. This organic extract is dried over anhydrous sodium sulphate and evaporated to afford 6-methylisoquinoline (yield 7 1 %, m.p. 88 °C).
Synthesis Reference(s)
The Journal of Organic Chemistry, 48, p. 3344, 1983 DOI: 10.1021/jo00167a043
6-Methylisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Methylisoquinoline manufacturers
- Product
- 6-Methylisoquinoline 42398-73-2
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,50kg
- Release date
- 2020-01-18
- Product
- 6-Methylisoquinoline 5340-45-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1KG, 5KG, 50KG
- Release date
- 2020-01-14