ChemicalBook > CAS DataBase List > 6-Methylisoquinoline

6-Methylisoquinoline

Product Name
6-Methylisoquinoline
CAS No.
42398-73-2
Chemical Name
6-Methylisoquinoline
Synonyms
6-Methylisoquinoline;Isoquinoline, 6-methyl-;6-Methylisoquinoline 98%;6-Methylisoquinoline ,98%;3,4,4-trimethylpentan-2-one;6-Methylisoquinoline ISO 9001：2015 REACH
CBNumber
CB5879955
Molecular Formula
C10H9N
Formula Weight
143.19
MOL File
42398-73-2.mol
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6-Methylisoquinoline Property

Melting point:
85.5°C
Boiling point:
246.29°C (estimate)
Density 
1.0584 (estimate)
refractive index 
1.6103 (estimate)
pka
5.85±0.10(Predicted)
form 
solid
color 
Beige
CAS DataBase Reference
42398-73-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26-24/25
Hazard Note 
Irritant
HS Code 
29334900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M321770
Product name
6-Methylisoquinoline
Packaging
100mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR8565
Product name
6-Methylisoquinoline
Purity
98%
Packaging
1g
Price
$82
Updated
2021/12/16
Apolloscientific
Product number
OR8565
Product name
6-Methylisoquinoline
Purity
98%
Packaging
5g
Price
$180
Updated
2021/12/16
AK Scientific
Product number
Y9087
Product name
6-Methylisoquinoline
Packaging
25g
Price
$477
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0027846
Product name
6-METHYLISOQUINOLINE
Purity
95.00%
Packaging
250MG
Price
$657.54
Updated
2021/12/16
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6-Methylisoquinoline Chemical Properties,Usage,Production

Chemical Properties

Light beige powder

Uses

6-Methylisoquinoline (cas# 42398-73-2) is a useful reagent for the green preparation of polyfluoroarylated heterocyclic compounds.

Preparation

A benzene solution (50 ml, CAUTION) of equimolar amounts of p-tolualdehyde (8.4 g, 0.07 mol) and aminoacetaldehyde dimethyl acetal (7.35 g, 0.07 mol) is refluxed overnight into a Dean and Stark trap. The solution is evaporated in vacuo and then twice evaporated again with added benzene and the viscous oil dissolved in dry tetrahydrofuran. This solution is cooled to - 10 °C and 1 equivalent of ethyl chloroformate (7. 1 ml, 0.07 mol) is added with rapid stirring and the mixture stirred for a further 5 minutes. The cooling bath is removed and 1.2 equivalents of trimethyl phosphite ( 10.5 ml, 0.09 mol) is added with stirring. The solution is stirred at room temperature for 1 5 hours and then evaporated t o an oil. The oil is then re-evaporated twice with added toluene to remove traces of trimethyl phosphite. The oil is dissolved in dry dichloromethane, 6 equivalents of titanium(1v) chloride (50 ml, 0.45 mol) is added and the solution refluxed for 36 hours under a drying tube. The cooled solution is shaken with 1 equivalent of aqueous sodium hydroxide solution to neutrality, whereupon titanium(1v) oxide precipitates as a white solid. The filtered organic layer is extracted with 3 M hydrochloric acid, and the extract is washed with dichloromethane, basified strongly with aqueous alkali, and extracted with dichloromethane. This organic extract is dried over anhydrous sodium sulphate and evaporated to afford 6-methylisoquinoline (yield 7 1 %, m.p. 88 °C).

Synthesis Reference(s)

The Journal of Organic Chemistry, 48, p. 3344, 1983 DOI: 10.1021/jo00167a043

6-Methylisoquinoline Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid Ethanol Aminoacetaldehyde dimethyl acetal p-Tolualdehyde Toluene Sodium borohydride Triethylamine Ethyl chloroformate Aluminum chloride Tosyl chloride Tetrahydrofuran Trimethyl phosphite Potassium sodium tartrate tetrahydrate Hydrochloric acid Sodium bicarbonate Dichloromethane Titanium tetrachloride Pyridine

Preparation Products

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View Lastest Price from 6-Methylisoquinoline manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
6-Methylisoquinoline 42398-73-2
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-29
Career Henan Chemical Co
Product
6-Methylisoquinoline 42398-73-2
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,50kg
Release date
2020-01-18
Career Henan Chemical Co
Product
6-Methylisoquinoline 5340-45-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1KG, 5KG, 50KG
Release date
2020-01-14

42398-73-2, 6-MethylisoquinolineRelated Search:

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  • 6-Methylisoquinoline 98%
  • 6-Methylisoquinoline
  • Isoquinoline, 6-methyl-
  • 6-Methylisoquinoline ,98%
  • 3,4,4-trimethylpentan-2-one
  • 6-Methylisoquinoline ISO 9001：2015 REACH
  • 42398-73-2
  • 5340-45-5
  • Quinoline&Isoquinoline
  • Isoquinoline Derivertives
  • blocks
  • Heterocycles
  • Quinolines
  • Heterocyclic Series