Dimethyl acetylmethylphosphonate
- Product Name
- Dimethyl acetylmethylphosphonate
- CAS No.
- 4202-14-6
- Chemical Name
- Dimethyl acetylmethylphosphonate
- Synonyms
- DIMETHYL (2-OXOPROPYL)PHOSPHONATE;DIMETHYL ACE;LABOTEST-BB LT00847718;Dimethyl(2-oxopropyl)phosph;DIMETHYL ACETONYLPHOSPHONATE;Dimethyl acetylmethylphosphote;DIMETHYL ACETYLMETHYLPHOSPHONATE;1-Dimethoxyphosphorylpropan-2-one;Dimethyle(2-oxopropyl)phosphonate;Dimethyl 2-oxopropylphosphonate 95%
- CBNumber
- CB6339733
- Molecular Formula
- C5H11O4P
- Formula Weight
- 166.11
- MOL File
- 4202-14-6.mol
Dimethyl acetylmethylphosphonate Property
- Boiling point:
- 76-79 °C3 mm Hg(lit.)
- Density
- 1.202 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.439(lit.)
- Flash point:
- 200 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Difficult to mix.
- form
- Liquid
- color
- Clear colorless to light brown
- BRN
- 1766218
- InChI
- InChI=1S/C5H11O4P/c1-5(6)4-10(7,8-2)9-3/h4H2,1-3H3
- InChIKey
- UOWIYNWMROWVDG-UHFFFAOYSA-N
- SMILES
- P(CC(=O)C)(=O)(OC)OC
- CAS DataBase Reference
- 4202-14-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Dimethyl (2-oxopropyl)phosphonate(4202-14-6)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 180696
- Product name
- Dimethyl 2-oxopropylphosphonate
- Purity
- 95%
- Packaging
- 5g
- Price
- $27.34
- Updated
- 2025/07/31
- Product number
- 180696
- Product name
- Dimethyl 2-oxopropylphosphonate
- Purity
- 95%
- Packaging
- 25g
- Price
- $163
- Updated
- 2025/07/31
- Product number
- O0208
- Product name
- Dimethyl (2-Oxopropyl)phosphonate
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $55
- Updated
- 2025/07/31
- Product number
- O0208
- Product name
- Dimethyl (2-Oxopropyl)phosphonate
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $222
- Updated
- 2025/07/31
- Product number
- D476790
- Product name
- Dimethyl 2-oxopropylphosphonate
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
Dimethyl acetylmethylphosphonate Chemical Properties,Usage,Production
Chemical Properties
CLEAR COLOURLESS TO LIGHT BROWN LIQUID
Uses
Dimethyl acetylmethylphosphonate is a Reagent used together with tosyl azide in a one-pot alkynylation of aldehydes.
Synthesis Reference(s)
Tetrahedron Letters, 17, p. 2829, 1976 DOI: 10.1016/S0040-4039(01)85513-1
reaction suitability
reaction type: C-C Bond Formation
Synthesis
78-95-5
121-45-9
4202-14-6
General procedure for the synthesis of dimethyl acetone-based phosphonate from chloroacetone and trimethoxyphosphine: a dry and clean 500 mL coil was heated to 135 °C. 1000 g (0.7 eq., 10.81 mol) of chloroacetone (boiling point 117 to 119 °C at standard atmospheric pressure) was placed in charge bottle A and diluted with 4000 g of toluene. 1878 g (1.0 eq., 15.13 mol) of trimethoxyphosphine (boiling point at 112°C at standard atmospheric pressure) was placed in charge bottle B and diluted with 3122 g of toluene. After the temperature was stabilized, batch pumping of the chloroacetone-toluene solution in Bottle A and the trimethoxyphosphine-toluene solution in Bottle B was started at a rate of 12.5 g/min. The residence time of the reactants was 20 min, and the reaction pressure was maintained at 0.5 to 2.0 MPa. The reacted mixture was directly introduced into a thin-film evaporation unit, with a controlled pressure of 4 to 10 x 10^2 Pa and a temperature of between 60 and 70 °C. The reaction was carried out at a pressure of 4 to 10 x 10^2 Pa. Ultimately, 1230 g of dimethyl acetone-based phosphonate (boiling point 85 to 88 °C, 666 Pa) was obtained in 88% yield.
References
[1] Patent: CN107163079, 2017, A. Location in patent: Paragraph 0076; 0077; 0078
[2] Organic Letters, 2015, vol. 17, # 5, p. 1308 - 1311
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 21, p. 8765 - 8780
[4] Journal of the American Chemical Society, 1995, vol. 117, # 10, p. 2931 - 2932
[5] Organic and Biomolecular Chemistry, 2017, vol. 15, # 15, p. 3304 - 3309
Dimethyl acetylmethylphosphonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Dimethyl acetylmethylphosphonate manufacturers
- Product
- Dimethyl acetylmethylphosphonate 4202-14-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- Dimethyl acetonylphosphonate 4202-14-6
- Price
- US $1.00-35.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 350000KG
- Release date
- 2024-08-06
- Product
- DiMethyl (2-oxopropyl)phosphonate 4202-14-6
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2020-01-14