ChemicalBook > CAS DataBase List > 2,3,4-Trimethoxybenzaldehyde

2,3,4-Trimethoxybenzaldehyde

Product Name
2,3,4-Trimethoxybenzaldehyde
CAS No.
2103-57-3
Chemical Name
2,3,4-Trimethoxybenzaldehyde
Synonyms
TriMetazidine EP IMpurity-C;Benzaldehyde, 2,3,4-trimethoxy-;2,3,4-TMB;AKOS BBS-00003174;2,3,4-TrimethoxybenzaL;Trimetazidine Impurity C;4-TriMethoxybenzaldehyde;trimetazidine impurity1139;2,3,4-Trimetoxybenzaldehyde;Trimetazidine intermediate
CBNumber
CB9260504
Molecular Formula
C10H12O4
Formula Weight
196.2
MOL File
2103-57-3.mol
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2,3,4-Trimethoxybenzaldehyde Property

Melting point:
38-40 °C(lit.)
Boiling point:
168-170 °C12 mm Hg(lit.)
Density 
1.2166 (rough estimate)
refractive index 
n20/D 1.5547(lit.)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
methanol: 0.1 g/mL, clear
form 
Crystals or Crystalline Powder
color 
White to light yellow
Sensitive 
Air Sensitive
BRN 
981091
InChI
InChI=1S/C10H12O4/c1-12-8-5-4-7(6-11)9(13-2)10(8)14-3/h4-6H,1-3H3
InChIKey
UCTUXUGXIFRVGX-UHFFFAOYSA-N
SMILES
C(=O)C1=CC=C(OC)C(OC)=C1OC
CAS DataBase Reference
2103-57-3(CAS DataBase Reference)
NIST Chemistry Reference
Benzaldehyde, 2,3,4-trimethoxy-(2103-57-3)
EPA Substance Registry System
Benzaldehyde, 2,3,4-trimethoxy- (2103-57-3)
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Safety

Hazard Codes 
Xi,C
Risk Statements 
36/37/38-34
Safety Statements 
22-24/25-45-36/37/39-27-26
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29124900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
152099
Product name
2,3,4-Trimethoxybenzaldehyde
Purity
99%
Packaging
10g
Price
$34.3
Updated
2025/07/31
Sigma-Aldrich
Product number
152099
Product name
2,3,4-Trimethoxybenzaldehyde
Purity
99%
Packaging
50g
Price
$111
Updated
2025/07/31
TCI Chemical
Product number
T1101
Product name
2,3,4-Trimethoxybenzaldehyde
Purity
>98.0%(GC)
Packaging
25g
Price
$63
Updated
2025/07/31
TRC
Product number
T795685
Product name
2,3,4-Trimethoxybenzaldehyde
Packaging
100g
Price
$215
Updated
2021/12/16
TRC
Product number
T795685
Product name
2,3,4-Trimethoxybenzaldehyde
Packaging
25g
Price
$85
Updated
2021/12/16
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2,3,4-Trimethoxybenzaldehyde Chemical Properties,Usage,Production

Description

2,3,4-Trimethoxybenzaldehyde is a white crystalline powder, and the chemical formula is C 10H 12O 4; the molecular weight is 196.2; the fusing point is 38-40 degrees, and is a kind of important medicine intermediate; it is mainly used in new type drug Ca2+ Synthesizing of channel blocker. The alternative cerebral arteries that are used for this medicine reduce the headache incidence, mainly for the preparation of the intermediate of trimetazidine.

Synthesis

A coking gallic acid is utilized as a raw material, and dimethyl sulfate is utilized as an alkylate reagent; under the condition of the existence of sodium hydroxide, methylation is performed through an O-alkylation reaction to obtain an intermediate 1, 2, 3-trimethoxybenzene. After that, the 1,2, 3-trimethoxybenzene and a Vilsmeier-Haack reagent are subjected to a formylation reaction to get the 2,3,4-Trimethoxybenzaldehyde.

Chemical Properties

white to light yellow crystals or cryst. powder

Uses

2,3,4-Trimethoxybenzaldehyde is a trimethoxylated aromatic aldehyde. 2,3,4-Trimethoxybenzaldehyde is an Impurity of the anti-anginal drug Trimetazidine (T795610).

Uses

2,3,4-Trimethoxybenzaldehyde was used to study the effects of 2,3,4-trimethoxybenzaldehyde on tubulin-dependent GTP hydrolysis.

References

[1] Organic and Biomolecular Chemistry, 2014, vol. 12, # 22, p. 3721 - 3734
[2] Molecules, 2015, vol. 20, # 5, p. 9229 - 9241
[3] Justus Liebigs Annalen der Chemie, 1972, vol. 763, p. 109 - 120

2,3,4-Trimethoxybenzaldehyde Preparation Products And Raw materials

Raw materials

Gallic acid

Preparation Products

Trimethoprim
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View Lastest Price from 2,3,4-Trimethoxybenzaldehyde manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
2,3,4-Trimethoxybenzaldehyde 2103-57-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-27
Hebei Chuanghai Biotechnology Co., Ltd
Product
2,3,4-Trimethoxybenzaldehyde 2103-57-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Jiurui Biology Chemistry Co.,Ltd.
Product
2,3,4-Trimethoxy Benzaldehyde 2103-57-3
Price
US $1.00/KG
Min. Order
100KG
Purity
99%MIN.
Supply Ability
100MT/Year
Release date
2022-08-17

2103-57-3, 2,3,4-TrimethoxybenzaldehydeRelated Search:

3-(Trifluoromethyl)benzaldehyde 3-Methoxybenzaldehyde p-Anisaldehyde 4-(Trifluoromethoxy)aniline Trimethyl phosphite Mesitaldehyde 3-(Trifluoromethoxy)bromobenzene o-Anisaldehyde (Trifluoromethoxy)benzene 2,3,4-Trihydroxybenzaldehyde 2,3,4-TRIMETHOXYPHENYLACETIC ACID TriMethopriM IMpurity C 3-Iodobenzyl bromide 3-Anilino-2-(3,4,5-triMethoxybenzyl)acrylonitrile, (Mixture of cis/trans isoMers) Trimethoprim Related Compound B (25 mg) (2,4-diaminopyrimidin-5-yl)(3,4,5-trimethoxyphenyl)methanone) (AS) 1,4-Bis(2,3,4-triMethoxybenzyl)piperazine 4-[(2,3,4-TriMethoxyphenyl)Methyl]-1-piperazinecarboxylic Acid Ethyl Ester 1-(3,4,5-TRIMETHOXY-BENZYL)-PIPERAZINE

  • 2,3,4-trimethoxy-benzaldehyd
  • 2,3,4-TRIMETHOXYBENZALDEHYDE FOR SYNTHES
  • TriMetazidine EP IMpurity-C
  • Trimetazidine Impurity C
  • 2,3,4-TriMethoxybenzaldehyde, 97+%
  • 2,3,4-TrimethoxybenzaL
  • 2,3,4-Trimedhoxy Benzaldehyde
  • Trimetazidine Impurity 3（Trimetazidine EP Impurity C)
  • 2,3,4-Trimethoxybenzaidehyde
  • 2,3,4 TRIMETHOXYBENZYLALDEHYDE
  • 2,3,4-TRIMETHOXYBENZALDEHYDE
  • 2,3,4-TMB
  • 2,3,4-Trimethoxybenzaldehyde, 99+%
  • Benzaldehyde, 2,3,4-trimethoxy-
  • 2,3,4-trimethoxybenzaldehyde (intermediate of trimetazidine.)
  • 2,3,4-Trimetoxybenzaldehyde
  • 4.2,3,4-trimethoxybenzaldehyde
  • 2,3,4-TRIMETHOXYBENZALDEHYDE, 98+%
  • 4-TriMethoxybenzaldehyde
  • 2,3,4-TriMethoxybenzaldehyde, 99% 10GR
  • AKOS BBS-00003174
  • 2,3,4-Trimethoxybenzaldehyde ISO 9001：2015 REACH
  • trimetazidine impurity1139
  • 2,3,4-Trimethoxybenzaldehyde (Trimetazidine Hydrochloride Impurity)
  • Trimetazidine intermediate
  • Trimetazidine Dihydrochloride EP Impurity C
  • Trimetazidine Dihydrochloride Impurity C
  • 2103-57-3
  • 2103-57-31
  • Organic Building Blocks
  • ALDEHYDE
  • Aldehydes
  • Building Blocks
  • C10 to C21
  • Carbonyl Compounds
  • Aromatics, Impurities, Intermediates
  • BUILDING BLOCKS
  • Benzaldehyde
  • API intermediates
  • (intermediate of trimetazidine.)
  • Aldehydes
  • C10 to C21
  • Carbonyl Compounds
  • Aromatic Aldehydes & Derivatives (substituted)
  • bc0001
  • 2103-57-3