SODIUM CARBONATE, MONOHYDRATE Property

Melting point:

851 °C(lit.)

Boiling point:

1600 °C

Density 

2.53

storage temp. 

Store at RT.

solubility 

H₂O: 1 M at 20 °C, clear, colorless

form 

Powder/Solid

Specific Gravity

2.25

color 

White

Water Solubility 

Soluble in water. Insoluble in alcoholSoluble in water and glycerol. Insoluble in alcohol, acetone, alkyl acetates,benzonitrile and liquid ammonia.

Sensitive 

Hygroscopic

Merck 

14,8596

Dielectric constant

3.0（Ambient）

Stability:

Stable. Incompatible with strong acids, aluminium, fluorine, lithium, phosphorus oxides.

LogP

-0.809 (est)

CAS DataBase Reference

5968-11-6(CAS DataBase Reference)

EPA Substance Registry System

Sodium carbonate, monohydrate (5968-11-6)

Safety

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26-22

WGK Germany 

1

RTECS 

VZ4050000

F 

3

TSCA 

Yes

HS Code 

28362000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

SODIUM CARBONATE, MONOHYDRATE Chemical Properties,Usage,Production

Chemical Properties

white powder

Chemical Properties

Sodium carbonate is a white, almost white, or colorless inorganic salt, produced as crystalline powder or granules. It is hygroscopic and odorless with an alkaline taste.

Uses

Buffers; pH adjustment.

Uses

Sodium Carbonate Monohydrate can be used for sterilization or virus inactivating agent composition.

Uses

Buffer component, may be used for the removal of peripheral membrane proteins.

Production Methods

Sodium carbonate is produced by the ammonia-soda process, also known as the Solvay process.

Pharmaceutical Applications

Sodium carbonate is used as an alkalizing agent in injectable, ophthalmic, oral, and rectal formulations. In effervescent tablets or granules, sodium carbonate is used in combination with an acid, typically citric acid or tartaric acid. When the tablets or granules come into contact with water, an acid– base reaction occurs in which carbon dioxide gas is produced and the product disintegrates. Raw materials with low moisture contents are required to prevent the early triggering of the effervescent reaction.
As an alkalizing agent, concentrations of sodium carbonate between 2% and 5% w/w are used in compressed tablet formulations. As an effervescent agent, concentrations of sodium carbonate up to 10% w/w can be used.
Therapeutically, sodium carbonate is also used as an oral antacid.

Industrial uses

The most prominent characteristic of soda ash in solution is the high buffered pH response. For example, changing the sodium carbonate dosage from 0.03% to 30% only causes the solution pH to change from 10.5 to 11.7. Because of this, in mineral processing application, soda ash is used for pH control to a maximum value of 10.5.

Industrial uses

Soda ash is the name of various grades of sodium carbonate (Na2CO3). A large portion of soda ash is manufactured via the Solvay process, based on the following reaction:
NH₃ + CO₂ + H₂O → NH₄HCO₃
NaCl + NH₄HCO₃→ NaHCO₃ + NH₄Cl
2NaHCO₃ + heat → Na₂CO₃ + CO₂ (recycled)
Soda ash is an off-white to white anhydrous powder or granular material. The quality of soda ash is usually characterized by the percent of sodium oxide (Na₂O) content.

Safety

Sodium carbonate is used in injectable, oral, and rectal pharmaceutical formulations. The pure form of sodium carbonate is mildly toxic by ingestion, moderately toxic by inhalation and SC routes, and very toxic by the IP route. It is irritating to the skin and eyes. Dust and vapors of sodium carbonate may irritate mucous membranes, causing coughing and shortness of breath. It also has experimental reproductive effects.
Sodium carbonate can migrate to food from packaging materials. When used as an excipient or antacid, sodium carbonate is generally regarded as a nontoxic and nonirritating material.
LD50 (mouse, IP): 0.12 g/kg
LD50 (mouse, SC): 2.21 g/kg
LD50 (rat, oral): 4.09 g/kg

storage

Sodium carbonate converts to the monohydrate form when in contact with water and produces heat. It begins to lose carbon dioxide at temperatures above 400℃ and decomposes before boiling. Store in airtight containers.

Incompatibilities

Sodium carbonate decomposes when in contact with acids in the presence of water to produce carbon dioxide and effervescence. It may react violently with aluminum, phosphorous pentoxide, sulfuric acid, fluorine, and lithium.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections; ophthalmic solution; oral capsules and tablets; rectal suspensions). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in parenteral (powder for solution for injection) and nonparenteral medicines (oral effervescent tablets, soluble tablets, granules, lozenges, chewing gums) licensed in the UK.
USP32–NF27 allows either the anhydrous or the monohydrate form.