1-NAPHTHHYDRAZIDE
- Product Name
- 1-NAPHTHHYDRAZIDE
- CAS No.
- 43038-45-5
- Chemical Name
- 1-NAPHTHHYDRAZIDE
- Synonyms
- SKL728;AKOS BC-1515;1-phthhydrazide;1-NAPHTHHYDRAZIDE;1-NAPHTHOHYDRAZIDE;1-Naphthoylhydrazine;A-NAPHTHOYLHYDRAZINE;1-NAPHTHOIC HYDRAZIDE;SPECS AN-068/40186625;1-Naphthohydrazide>
- CBNumber
- CB1706406
- Molecular Formula
- C11H10N2O
- Formula Weight
- 186.21
- MOL File
- 43038-45-5.mol
1-NAPHTHHYDRAZIDE Property
- Melting point:
- 166-168°C
- Density
- 1.232±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 12.65±0.30(Predicted)
- color
- White to Light yellow
- BRN
- 2966714
- InChI
- InChI=1S/C11H10N2O/c12-13-11(14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7H,12H2,(H,13,14)
- InChIKey
- VMFUMDXVTKTZQY-UHFFFAOYSA-N
- SMILES
- C1(C(NN)=O)=C2C(C=CC=C2)=CC=C1
- CAS DataBase Reference
- 43038-45-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- N0776
- Product name
- 1-Naphthohydrazide
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $189
- Updated
- 2025/07/31
- Product number
- N369028
- Product name
- 1-Naphthohydrazide
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- AK-95950
- Product name
- 1-Naphthohydrazide
- Purity
- 98%
- Packaging
- 10g
- Price
- $64
- Updated
- 2021/12/16
- Product number
- 4656-1-50
- Product name
- 1-Naphthhydrazide
- Packaging
- 5G
- Price
- $89
- Updated
- 2021/12/16
- Product number
- 006585
- Product name
- 1-Naphthhydrazide
- Packaging
- 25g
- Price
- $207
- Updated
- 2021/12/16
1-NAPHTHHYDRAZIDE Chemical Properties,Usage,Production
Synthesis
2459-24-7
43038-45-5
General procedure for the synthesis of 1-naphthylhydrazine from methyl 1-naphthalenecarboxylate: Methyl 1-naphthalenecarboxylate (0.52 g, 2.8 mmol) was dissolved in 15 mL of 98% hydrazine hydrate, fitted with an air condenser tube, and the reaction was stirred for 8 h at 110 °C. The reaction was carried out in the presence of an air condenser tube. Upon completion of the reaction, the mixture was cooled to room temperature and the precipitated crystalline solid was collected by filtration. The resulting solid was dissolved in ethyl acetate (EtOAc), and the organic phase was washed sequentially with water, saturated sodium bicarbonate (NaHCO3) solution and brine, and then concentrated under reduced pressure to remove the solvent. The product was purified by column chromatography (elution gradient: hexane/ethyl acetate 1:1; hexane/ethyl acetate 1:2) to give 0.38 g (73% yield) of white crystalline solid. Thin layer chromatography (TLC) Rf = 0.53 (unfolding agent: chloroform/methanol 10:1). Melting point 166-169 °C (literature value 166 °C).IR (KBr, cm-1): νmax 3280 (N-H), 1658 (C=O), 1606, 1588, 1524, 1261, 955.1H NMR (300 MHz, DMSO-d6): δ 9.69 (s, 1H, NH), 8.35-8.10 (m. 1H, Ar-H), 8.05-7.88 (m, 2H, Ar-H), 7.63-7.26 (m, 4H, Ar-H), 4.60 (s, 2H, NH2).13C NMR (75 MHz, DMSO-d6): δ 168.2 (C=O), 133.6, 133.3, 130.2, 130.1, 128.4, 128.4 126.8, 126.4, 125.6, 125.6, 125.2 (Ar-C).
References
[1] European Journal of Medicinal Chemistry, 2016, vol. 120, p. 97 - 110
[2] Journal of the American Chemical Society, 2010, vol. 132, # 20, p. 6900 - 6901
[3] Chemistry - A European Journal, 2011, vol. 17, # 30, p. 8294 - 8298
[4] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 11, p. 3615 - 3621
[5] RSC Advances, 2015, vol. 5, # 37, p. 28996 - 29001
1-NAPHTHHYDRAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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