ChemicalBook > CAS DataBase List > 1-NAPHTHHYDRAZIDE

1-NAPHTHHYDRAZIDE

Product Name: 1-NAPHTHHYDRAZIDE
CAS No.: 43038-45-5
Chemical Name: 1-NAPHTHHYDRAZIDE
Synonyms: SKL728;AKOS BC-1515;1-phthhydrazide;1-NAPHTHHYDRAZIDE;1-NAPHTHOHYDRAZIDE;1-Naphthoylhydrazine;A-NAPHTHOYLHYDRAZINE;1-NAPHTHOIC HYDRAZIDE;SPECS AN-068/40186625;1-Naphthohydrazide>
CBNumber: CB1706406
Molecular Formula: C11H10N2O
Formula Weight: 186.21
MOL File: 43038-45-5.mol

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1-NAPHTHHYDRAZIDE Property

Melting point:: 166-168°C
Density: 1.232±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 12.65±0.30(Predicted)
color: White to Light yellow
BRN: 2966714
InChI: InChI=1S/C11H10N2O/c12-13-11(14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7H,12H2,(H,13,14)
InChIKey: VMFUMDXVTKTZQY-UHFFFAOYSA-N
SMILES: C1(C(NN)=O)=C2C(C=CC=C2)=CC=C1
CAS DataBase Reference: 43038-45-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
HS Code: 2928.00.2500
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: N0776
Product name: 1-Naphthohydrazide
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $189
Updated: 2025/07/31

TRC

Product number: N369028
Product name: 1-Naphthohydrazide
Packaging: 100mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4656-1-50
Product name: 1-Naphthhydrazide
Packaging: 1g
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 006585
Product name: 1-Naphthhydrazide
Packaging: 5g
Price: $50
Updated: 2021/12/16

Ark Pharm

Product number: AK-95950
Product name: 1-Naphthohydrazide
Purity: 98%
Packaging: 10g
Price: $64
Updated: 2021/12/16

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1-NAPHTHHYDRAZIDE Chemical Properties,Usage,Production

Synthesis

2459-24-7

43038-45-5

General procedure for the synthesis of 1-naphthylhydrazine from methyl 1-naphthalenecarboxylate: Methyl 1-naphthalenecarboxylate (0.52 g, 2.8 mmol) was dissolved in 15 mL of 98% hydrazine hydrate, fitted with an air condenser tube, and the reaction was stirred for 8 h at 110 °C. The reaction was carried out in the presence of an air condenser tube. Upon completion of the reaction, the mixture was cooled to room temperature and the precipitated crystalline solid was collected by filtration. The resulting solid was dissolved in ethyl acetate (EtOAc), and the organic phase was washed sequentially with water, saturated sodium bicarbonate (NaHCO3) solution and brine, and then concentrated under reduced pressure to remove the solvent. The product was purified by column chromatography (elution gradient: hexane/ethyl acetate 1:1; hexane/ethyl acetate 1:2) to give 0.38 g (73% yield) of white crystalline solid. Thin layer chromatography (TLC) Rf = 0.53 (unfolding agent: chloroform/methanol 10:1). Melting point 166-169 °C (literature value 166 °C).IR (KBr, cm-1): νmax 3280 (N-H), 1658 (C=O), 1606, 1588, 1524, 1261, 955.1H NMR (300 MHz, DMSO-d6): δ 9.69 (s, 1H, NH), 8.35-8.10 (m. 1H, Ar-H), 8.05-7.88 (m, 2H, Ar-H), 7.63-7.26 (m, 4H, Ar-H), 4.60 (s, 2H, NH2).13C NMR (75 MHz, DMSO-d6): δ 168.2 (C=O), 133.6, 133.3, 130.2, 130.1, 128.4, 128.4 126.8, 126.4, 125.6, 125.6, 125.2 (Ar-C).

References

[1] European Journal of Medicinal Chemistry, 2016, vol. 120, p. 97 - 110
[2] Journal of the American Chemical Society, 2010, vol. 132, # 20, p. 6900 - 6901
[3] Chemistry - A European Journal, 2011, vol. 17, # 30, p. 8294 - 8298
[4] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 11, p. 3615 - 3621
[5] RSC Advances, 2015, vol. 5, # 37, p. 28996 - 29001

1-NAPHTHHYDRAZIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-NAPHTHHYDRAZIDE Suppliers

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43038-45-5, 1-NAPHTHHYDRAZIDERelated Search:

LUCIFER YELLOW CH DILITHIUM SALT 1-NAPHTHHYDRAZIDE 1-(4-METHOXYBENZOYL)-2-(1-NAPHTHOYL)-HYDRAZINE 1-(3-METHOXYBENZOYL)-2-(1-NAPHTHOYL)-HYDRAZINE 2-NAPHTHHYDRAZIDE LUCIFER YELLOW CH DIPOTASSIUM SALT 2-AMINO-2,3-DIHYDRO-1H-BENZO[DE]ISOQUINOLINE-1,3-DIONE AKOS BBS-00007400 LUCIFER YELLOW CH, AMMONIUM SALT AKOS BBS-00007401 2-AMINO-6-NITRO-BENZO[DE]ISOQUINOLINE-1,3-DIONE 2-(4-OXO-2-THIOXO-5-([2-(TRIFLUOROMETHYL)PHENYL]METHYLENE)-1,3-THIAZOLAN-3-YL)-1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONE 1-(2,4-DICHLOROBENZOYL)-2-(1-NAPHTHOYL)HYDRAZINE SALOR-INT L401846-1EA SALOR-INT L400904-1EA 2-AMINO-6-BENZOYL-BENZO[DE]ISOQUINOLINE-1,3-DIONE 2-AMINO-5-NITRO-BENZO[DE]ISOQUINOLINE-1,3-DIONE N'-(2-CHLOROACETYL)-1-NAPHTHOHYDRAZIDE

ALPHA-NAPHTHOYLHYDRAZINE

AKOS BC-1515

1-NAPHTHOIC HYDRAZIDE

1-NAPHTHOHYDRAZIDE

1-NAPHTHOIC ACID HYDRAZIDE

1-NAPHTHHYDRAZIDE

1-NAPHTHALENECARBOHYDRAZIDE

1-Naphthalenecarboxylic acid, hydrazide

1-Naphthoylhydrazine

1-NAPHTHOIC HYDRAZIDE, 98+%

1-naphthohydrazide(SALTDATA: FREE)

4-Quinolinecarboxylic acid, hydrazide

A-NAPHTHOYLHYDRAZINE

1-phthhydrazide

SPECS AN-068/40186625

1-Naphthohydrazide&gt

SKL728

43038-45-5

C11H10N2O

Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes

Miscellaneous Compounds