ChemicalBook > CAS DataBase List > NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

Product Name
NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
CAS No.
220805-22-1
Chemical Name
NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
Synonyms
ADMA;ADMA 2HCL;ADMA DIHYDROCHLORIDE;asym-Dimethylarginine;asym-Dimethylarginine, ADMA;Arginine Impurity 12 Dihydrochloride;NG,NG-DIMETHYLARGININE, DIHYDROCHLORIDE;NG,NG-dimethyl-L-Arginine (hydrochloride);NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE;NG,NG-Dimethylarginine Dihydrochloride，ADMA
CBNumber
CB1706734
Molecular Formula
C8H20Cl2N4O2
Formula Weight
275.18
MOL File
220805-22-1.mol
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NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Property

Melting point:
202-204OC
storage temp. 
room temp
solubility 
DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
form 
White to off-white crystalline solid.
color 
White to Off-White
Water Solubility 
Soluble in water (100 mM)
Stability:
Store at 0-5°C; Moisture Sensitive; Hygroscopic
CAS DataBase Reference
220805-22-1
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D4268
Product name
NG,NG-Dimethylarginine dihydrochloride
Packaging
10mg
Price
$80.7
Updated
2024/03/01
Sigma-Aldrich
Product number
D4268
Product name
NG,NG-Dimethylarginine dihydrochloride
Packaging
50mg
Price
$281
Updated
2024/03/01
Sigma-Aldrich
Product number
311203
Product name
NG,NG-Dimethyl-L-arginine, Dihydrochloride - CAS 220805-22-1 - Calbiochem
Purity
A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC?? = 2-3 μM) and in vivo.
Packaging
25MG
Price
$187
Updated
2024/03/01
Cayman Chemical
Product number
80230
Product name
NG,NG-dimethyl-L-Arginine (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
80230
Product name
NG,NG-dimethyl-L-Arginine (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$45
Updated
2024/03/01
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NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells

Uses

NG,NG- Dimethylarginine dihydrochloride has been used:

  • to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
  • as a standard for measuring L-arginine and dimethylarginines
  • to study its effects on hepatic deterioration

General Description

NG,NG-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).

Biological Activity

ng,ng-dimethyl-l-arginine is an endogenous nitric oxide synthase inhibitor.nitric oxide (no) that is synthesised from l-arginine contributes to the regulation of blood pressure and to host defence.

Biochem/physiol Actions

Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.

in vitro

ng,ng-dimethyl-l-arginine (adma) was found to be able to inhibit macrophage and vascular no synthase. when added to a cytosolic preparation of macrophage no synthase, adma could cause dose-dependent inhibition of no formation. in the presence of added arginine, adma could inhibited no synthesis and the inhibitory effects of adma were prevented by addition of l-arginine so that the rate of no synthesis did not significantly differ from control values [1].

in vivo

animal study showed that the injection of 1-30 mg/kg adma into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. moreover, during continuous infusion of adma, which caused plasma adma concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].

storage

Room temperature (desiccate)

References

[1] vallance, p. ,leone, a.,calver, a., et al. accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. lancet 339, 572-575 (1992).

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Suppliers

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220805-22-1, NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDERelated Search:

L-N5-(1-IMINOETHYL)ORNITHINE*HYDROCHLORI DE Aminoguanidine bicarbonate NG-MONOMETHYL-L-ARGININE ACETATE AMINOGUANIDINE HEMISULFATE IroMycin A 2-IMINOBIOTIN HYDROBROMIDE N'-Nitro-L-arginine-methyl ester hydrochloride S-ISOPROPYLTHIOUREA HYDROBROMIDE L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE L-THIOCITRULLINE DIHYDROCHLORIDE L-NAA HCL 7-NINA L-Ornithine DL-ORNITHINE DIHYDROCHLORIDE L-ORNITHINE DIHYDROCHLORIDE NG,NG'-DIMETHYL-L-ARGININE, DIHYDROCHLORIDE H-ARG(ME)-OH NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

  • NG,NG-Dimethylarginine Dihydrochloride Solution, 100ppm
  • asym-Dimethylarginine, ADMA
  • NG,NG-dimethyl-L-Arginine (hydrochloride)
  • (S)-2-aMino-5-(3,3-diMethylguanidino)pentanoic acid dihydrochloride
  • NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
  • NG,NG-DIMETHYLARGININE, DIHYDROCHLORIDE
  • N5-[(DIMETHYLAMINO)IMINOMETHYL]-L-ORNITHINE, DIHYDROCHLORIDE
  • ADMA
  • ADMA 2HCL
  • ADMA DIHYDROCHLORIDE
  • asym-Dimethylarginine
  • Arginine Impurity 12 Dihydrochloride
  • NG,NG-Dimethylarginine Dihydrochloride，ADMA
  • (Z)-N~5~-[amino(dimethylamino)methylidene]-L-ornithine dihydrochloride
  • NG，NG-dimethyl-L-Arginine hydrochloride (ADMA)
  • NG,NG dimethyl L Arginine dihydrochloride,NG,NGdimethylLArginine dihydrochloride
  • Asymmetric dimethylarginine (dihydrochloride)
  • 220805-22-1
  • Biochemicals and Reagents
  • BioChemical
  • Enzyme Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • L to O
  • Nitric Oxide Synthase
  • Amino Acids 13C, 2H, 15N
  • Amino Acids & Derivatives
  • Intermediates & Fine Chemicals
  • Pharmaceuticals