S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA

Product Name: S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA
CAS No.: 37686-84-3
Chemical Name: S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA
Synonyms: TDHL;dironyl;Teluron;tergurid;terguride;S(+)-TERGURIDE;R-(+)-TERGURIDE;TRANS-DIHYDROLISURIDE;(5R,8S,10R)-Terguride;9,10a-Dihydrolisuride
CBNumber: CB1710346
Molecular Formula: C20H28N4O
Formula Weight: 340.46
MOL File: 37686-84-3.mol

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S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Property

Melting point:: 203-204° (dec); mp 205-207° (dec) (Cerny)
alpha: D20 +30° (c = 1 in pyridine); D20 +29.0° (c = 0.2 in pyridine)
Boiling point:: 476.25°C (rough estimate)
Density: 1.1056 (rough estimate)
refractive index: 1.6620 (estimate)
storage temp.: 2-8°C
solubility: DMSO: soluble
form: solid
pka: 13.60±0.20(Predicted)
color: white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

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Safety

Hazard Codes: T
Risk Statements: 23/24/25
Safety Statements: 36/37/39-45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: YS9378700
Toxicity: LD50 oral in rat: 100mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Medical Isotopes, Inc.

Product number: 39958
Product name: trans-DihydroLisuride
Packaging: 10mg
Price: $2800
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0004355
Product name: TERGURIDE
Purity: 95.00%
Packaging: 10MG
Price: $2804.55
Updated: 2021/12/16

Alichem

Product number: 37686843
Product name: 1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea
Packaging: 1g
Price: $988.8
Updated: 2021/12/16

Crysdot

Product number: CD11133101
Product name: 1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea
Purity: 95+%
Packaging: 1g
Price: $1186
Updated: 2021/12/16

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S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Chemical Properties,Usage,Production

Description

Terguride (37686-84-3) is a semi-synthetic ergoline derivative which acts as a partial dopamine D2 agonist and 5HT2B/2C receptor antagonist. Displays antiparkinsonian effects in MPTP-treated cynomolgus monkeys.1?Partial agonist at recruitment of β-arrestin2 to the D2 receptor.2 Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.3

Uses

An ergot alkaloid derivative that acts as a partial dopamine D2-receptor agonist. An anti-hyperprolactinemia agent.

Definition

ChEBI: Terguride is an organic molecular entity.

References

1) Akai et al. (1993), Effects of terguride, a partial D2 agonist, on MPTP-lesioned parkinsonian cynomolgus monkeys; Ann. Neurol., 133 507 2) Klewe et al. (2008), Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling; Neuropharmacology, 54 1215 3) Dumitrascu et al. (2011), Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats; Eur. Respir. J., 37 1104

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Preparation Products And Raw materials

Raw materials

Preparation Products

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S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Suppliers

Canada 1 China 18 Germany 1 India 1 Switzerland 1 United States 9 Global 31

3B Pharmachem (Wuhan) International Co.,Ltd.

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LGM Pharma

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Chemsky (shanghai) International Co.,Ltd

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Aikon International Limited

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Hunan chemfish Scientific co.,ltd

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HUNAN CHEMFISH SCIENTIFIC CO.,LTD

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Energy Chemical

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TargetMol Chemicals Inc.

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Cdreamlab (Hubei) Technology Co., LTD

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37686-84-3, S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREARelated Search:

Etoposide Sodium 4-phenylbutyrate Sunitinib Malate Pioglitazone hydrochloride Cabergoline Bromocriptine n,n-diethyl-n’-((8-alpha)-6-methylergolin-8-yl)urea(z)-2-butenedioat R)-3-PHENYL PIPERIDINE 3-AMINOPIPERIDINE (S)-3-Aminopiperidine S-(-)-LISURIDE S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA 1H-Indole, 4-(3-piperidinyl)-, (R)- 3-AMINO-1-METHYL-PIPERIDINE 2 HCL α-Ethyltryptamine Proterguride

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA

S(+)-TERGURIDE

S(+)-TERGURIDE (5R, 8S, 10R)

R-(+)-TERGURIDE

TRANS-DIHYDROLISURIDE

1-((5r,8s,10r)-6-methyl-8-ergolinyl)-3,3-diethylurea

9,10-alpha-dihydrolisuride

N,N-Diethyl-N'-[(8α)-6-Methylergolin-8-yl]urea

dironyl

n,n-diethyl-n’-((8-alpha)-6-methylergolin-8-yl)-ure

tergurid

terguride

s(+)-n,n-diethyl-n'([8α]-6-methylergolin-8-yl)urea

(+)-(5R,8S,10R)-Terguride

(5R,8S,10R)-Terguride

6-Methyl-8a-(diethylcarbamoylamino)ergoline

9,10a-Dihydrolisuride

Ergoline, urea deriv.

Indolo[4,3-fg]quinoline, urea deriv.

N,N-Diethyl-N'-(D-6-methyl-10a-isoergolin-8-yl)urea

TDHL

Urea, N,N-diethyl-N'-[(8a)-6-methylergolin-8-yl]- (9CI)

S(+)-N,N-Diethyl-Nμ([8α]-6-methylergolin-8-yl)urea, S(+)-Terguride (5R, 8S, 10R)

1,1-Diethyl-3-(6-methylergolin-8α-yl)urea

Teluron

6-Methyl-8α-(diethylcarbaMoylaMino)ergoline

9,10α-Dihydrolisuride

N,N-Diethyl-N'-(D-6-Methyl-10α-isoergolin-8-yl)urea

Urea, N,N-diethyl-N'-[(8α)-6-methylergolin-8-yl]-

1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA

37686-84-3

Agonists

Heterocycles

Intermediates & Fine Chemicals

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