ChemicalBook > CAS DataBase List > S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA

Product Name
S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA
CAS No.
37686-84-3
Chemical Name
S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA
Synonyms
TDHL;dironyl;Teluron;tergurid;terguride;S(+)-TERGURIDE;R-(+)-TERGURIDE;TRANS-DIHYDROLISURIDE;(5R,8S,10R)-Terguride;9,10a-Dihydrolisuride
CBNumber
CB1710346
Molecular Formula
C20H28N4O
Formula Weight
340.46
MOL File
37686-84-3.mol
More
Less

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Property

Melting point:
203-204° (dec); mp 205-207° (dec) (Cerny)
alpha 
D20 +30° (c = 1 in pyridine); D20 +29.0° (c = 0.2 in pyridine)
Boiling point:
476.25°C (rough estimate)
Density 
1.1056 (rough estimate)
refractive index 
1.6620 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: soluble
form 
solid
pka
13.60±0.20(Predicted)
color 
white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
More
Less

Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
YS9378700
Toxicity
LD50 oral in rat: 100mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Medical Isotopes, Inc.
Product number
39958
Product name
trans-DihydroLisuride
Packaging
10mg
Price
$2800
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0004355
Product name
TERGURIDE
Purity
95.00%
Packaging
10MG
Price
$2804.55
Updated
2021/12/16
Alichem
Product number
37686843
Product name
1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea
Packaging
1g
Price
$988.8
Updated
2021/12/16
Crysdot
Product number
CD11133101
Product name
1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea
Purity
95+%
Packaging
1g
Price
$1186
Updated
2021/12/16
More
Less

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Chemical Properties,Usage,Production

Description

Terguride (37686-84-3) is a semi-synthetic ergoline derivative which acts as a partial dopamine D2 agonist and 5HT2B/2C receptor antagonist. Displays antiparkinsonian effects in MPTP-treated cynomolgus monkeys.1?Partial agonist at recruitment of β-arrestin2 to the D2 receptor.2 Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.3

Uses

An ergot alkaloid derivative that acts as a partial dopamine D2-receptor agonist. An anti-hyperprolactinemia agent.

Definition

ChEBI: Terguride is an organic molecular entity.

References

1) Akai et al. (1993), Effects of terguride, a partial D2 agonist, on MPTP-lesioned parkinsonian cynomolgus monkeys; Ann. Neurol., 133 507 2) Klewe et al. (2008), Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling; Neuropharmacology, 54 1215 3) Dumitrascu et al. (2011), Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats; Eur. Respir. J., 37 1104

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA Suppliers

Canada 1 China 18 Germany 1 India 1 Switzerland 1 United States 9 Global 31
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71

37686-84-3, S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREARelated Search:

Etoposide Sodium 4-phenylbutyrate Sunitinib Malate Pioglitazone hydrochloride Cabergoline Bromocriptine n,n-diethyl-n’-((8-alpha)-6-methylergolin-8-yl)urea(z)-2-butenedioat R)-3-PHENYL PIPERIDINE 3-AMINOPIPERIDINE (S)-3-Aminopiperidine S-(-)-LISURIDE S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA 1H-Indole, 4-(3-piperidinyl)-, (R)- 3-AMINO-1-METHYL-PIPERIDINE 2 HCL α-Ethyltryptamine Proterguride

  • S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA
  • S(+)-TERGURIDE
  • S(+)-TERGURIDE (5R, 8S, 10R)
  • R-(+)-TERGURIDE
  • TRANS-DIHYDROLISURIDE
  • 1-((5r,8s,10r)-6-methyl-8-ergolinyl)-3,3-diethylurea
  • 9,10-alpha-dihydrolisuride
  • N,N-Diethyl-N'-[(8α)-6-Methylergolin-8-yl]urea
  • dironyl
  • n,n-diethyl-n’-((8-alpha)-6-methylergolin-8-yl)-ure
  • tergurid
  • terguride
  • s(+)-n,n-diethyl-n'([8α]-6-methylergolin-8-yl)urea
  • (+)-(5R,8S,10R)-Terguride
  • (5R,8S,10R)-Terguride
  • 6-Methyl-8a-(diethylcarbamoylamino)ergoline
  • 9,10a-Dihydrolisuride
  • Ergoline, urea deriv.
  • Indolo[4,3-fg]quinoline, urea deriv.
  • N,N-Diethyl-N'-(D-6-methyl-10a-isoergolin-8-yl)urea
  • TDHL
  • Urea, N,N-diethyl-N'-[(8a)-6-methylergolin-8-yl]- (9CI)
  • S(+)-N,N-Diethyl-Nμ([8α]-6-methylergolin-8-yl)urea, S(+)-Terguride (5R, 8S, 10R)
  • 1,1-Diethyl-3-(6-methylergolin-8α-yl)urea
  • Teluron
  • 6-Methyl-8α-(diethylcarbaMoylaMino)ergoline
  • 9,10α-Dihydrolisuride
  • N,N-Diethyl-N'-(D-6-Methyl-10α-isoergolin-8-yl)urea
  • Urea, N,N-diethyl-N'-[(8α)-6-methylergolin-8-yl]-
  • 1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea
  • S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA
  • 37686-84-3
  • Agonists
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Neurochemicals
  • Pharmaceuticals
  • API