ChemicalBook > CAS DataBase List > 3-FLUORO-4-METHOXYBENZYL BROMIDE

3-FLUORO-4-METHOXYBENZYL BROMIDE

Product Name
3-FLUORO-4-METHOXYBENZYL BROMIDE
CAS No.
331-61-3
Chemical Name
3-FLUORO-4-METHOXYBENZYL BROMIDE
Synonyms
3-FLUORO-4-METHOXYBENZYL BROMIDE;3-Fluoro-4-methoxybenzyl bromide ,98%;4-(broMoMethyl)-2-fluoro-1-Methoxybenzene;Benzene, 4-(bromomethyl)-2-fluoro-1-methoxy-;4-(Bromomethyl)-2-fluoroanisole, 4-(Bromomethyl)-2-fluoro-1-methoxybenzene, 4-(Bromomethyl)-2-fluorophenyl methyl ether
CBNumber
CB1711732
Molecular Formula
C8H8BrFO
Formula Weight
219.05
MOL File
331-61-3.mol
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3-FLUORO-4-METHOXYBENZYL BROMIDE Property

Melting point:
44-46°C
Boiling point:
149-155 °C(Press: 25-28 Torr)
Density 
1.488±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
color 
Red
Sensitive 
Lachrymatory
CAS DataBase Reference
331-61-3(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xn
Risk Statements 
36/37/38-52-22-34
Safety Statements 
26-36/37/39-45
RIDADR 
UN3261
Hazard Note 
Corrosive/Lachrymatory
HazardClass 
8
PackingGroup 
III
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
F599395
Product name
3-Fluoro-4-methoxybenzylBromide
Packaging
1g
Price
$75
Updated
2021/12/16
Oakwood
Product number
013839
Product name
3-Fluoro-4-methoxybenzyl bromide
Packaging
1g
Price
$10
Updated
2021/12/16
SynQuest Laboratories
Product number
2707-B-34
Product name
3-Fluoro-4-methoxybenzyl bromide
Purity
98%
Packaging
1g
Price
$20
Updated
2021/12/16
Matrix Scientific
Product number
008958
Product name
3-Fluoro-4-methoxybenzyl bromide
Purity
98%
Packaging
5g
Price
$23
Updated
2021/12/16
Oakwood
Product number
013839
Product name
3-Fluoro-4-methoxybenzyl bromide
Packaging
5g
Price
$30
Updated
2021/12/16
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3-FLUORO-4-METHOXYBENZYL BROMIDE Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

96047-32-4

331-61-3

The general procedure for the synthesis of 3-fluoro-4-methoxybenzyl bromide from (3-fluoro-4-methoxyphenyl)methanol was as follows: at room temperature, (3-fluoro-4-methoxyphenyl)methanol (2.35 g, 15.05 mmol) and triethylamine (3.15 mL, 22.58 mmol) were dissolved in anhydrous dichloromethane (50 mL). Subsequently, methanesulfonyl chloride (1.41 mL, 18.06 mmol) was added dropwise. After 15 minutes of reaction, the reaction mixture was diluted with dichloromethane (50 mL) and the organic layer was washed with saturated aqueous sodium bicarbonate solution. The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was dissolved in anhydrous acetone (100 mL), excess lithium bromide was added and the mixture was heated to reflux for 30 minutes. After the reaction was complete, the solution was cooled and the solvent was evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water and the aqueous layer was extracted twice with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 3-fluoro-4-methoxybenzyl bromide (3.00 g, 91% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ7.16-7.07 (2H, m), 6.90 (1H, dd, J=8.3,8.4Hz), 4.45 (2H, s), 3.89 (3H, s).

References

[1] Patent: WO2017/155909, 2017, A1. Location in patent: Paragraph 0120
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 24, p. 6842 - 6846
[3] Chemical Biology and Drug Design, 2016, p. 97 - 109

3-FLUORO-4-METHOXYBENZYL BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-FLUORO-4-METHOXYBENZYL BROMIDE Suppliers

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View Lastest Price from 3-FLUORO-4-METHOXYBENZYL BROMIDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
3-FLUORO-4-METHOXYBENZYL BROMIDE 331-61-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-03
Career Henan Chemical Co
Product
3-FLUORO-4-METHOXYBENZYL BROMIDE 331-61-3
Price
US $1.00/KG
Min. Order
1IU
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-07

331-61-3, 3-FLUORO-4-METHOXYBENZYL BROMIDERelated Search:

3-FLUORO-4-(TRIFLUOROMETHOXY)BENZYL BROMIDE 3-FLUORO-4-METHOXYBENZYL BROMIDE 4-METHOXYTETRAFLUOROBENZYL BROMIDE 3-CHLORO-5-FLUORO-4-METHOXYBENZYL BROMIDE 3,5-DIFLUORO-4-METHOXYBENZYL BROMIDE 2,3-DIFLUORO-4-METHOXYBENZYL BROMIDE 2-CHLORO-6-FLUORO-3-METHOXYBENZYL BROMIDE 2-FLUORO-6-METHOXYBENZYL BROMIDE 5-Fluoro-2-methoxybenzyl bromide, 98+%,5-FLUORO-2-METHOXYBENZYL BROMIDE 97,5-Fluoro-2-methoxybenzyl bromide 97%,5-FLUORO-2-METHOXYBENZYL BROMIDE 6-CHLORO-2-FLUORO-3-METHOXYBENZYL BROMIDE 4-FLUORO-2-METHOXYBENZYL BROMIDE 4-FLUORO-3-METHOXYBENZYL BROMIDE 2,6-DIFLUORO-4-METHOXYBENZYL BROMIDE 4-Methoxybenzyl bromide 3-FLUORO-5-METHOXYBENZYL BROMIDE 3-FLUORO-2-METHOXYBENZYL BROMIDE 2-FLUORO-4-METHOXYBENZYL BROMIDE

  • 3-FLUORO-4-METHOXYBENZYL BROMIDE
  • 3-Fluoro-4-methoxybenzyl bromide ,98%
  • 4-(broMoMethyl)-2-fluoro-1-Methoxybenzene
  • 4-(Bromomethyl)-2-fluoroanisole, 4-(Bromomethyl)-2-fluoro-1-methoxybenzene, 4-(Bromomethyl)-2-fluorophenyl methyl ether
  • Benzene, 4-(bromomethyl)-2-fluoro-1-methoxy-
  • 331-61-3
  • Fluorine series