3-FLUORO-4-METHOXYBENZYL BROMIDE
- Product Name
- 3-FLUORO-4-METHOXYBENZYL BROMIDE
- CAS No.
- 331-61-3
- Chemical Name
- 3-FLUORO-4-METHOXYBENZYL BROMIDE
- Synonyms
- 3-FLUORO-4-METHOXYBENZYL BROMIDE;3-Fluoro-4-methoxybenzyl bromide ,98%;4-(broMoMethyl)-2-fluoro-1-Methoxybenzene;Benzene, 4-(bromomethyl)-2-fluoro-1-methoxy-;4-(Bromomethyl)-2-fluoroanisole, 4-(Bromomethyl)-2-fluoro-1-methoxybenzene, 4-(Bromomethyl)-2-fluorophenyl methyl ether
- CBNumber
- CB1711732
- Molecular Formula
- C8H8BrFO
- Formula Weight
- 219.05
- MOL File
- 331-61-3.mol
3-FLUORO-4-METHOXYBENZYL BROMIDE Property
- Melting point:
- 44-46°C
- Boiling point:
- 149-155 °C(Press: 25-28 Torr)
- Density
- 1.488±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- Red
- Sensitive
- Lachrymatory
- CAS DataBase Reference
- 331-61-3(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xn
- Risk Statements
- 36/37/38-52-22-34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN3261
- Hazard Note
- Corrosive/Lachrymatory
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29093090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- F599395
- Product name
- 3-Fluoro-4-methoxybenzylBromide
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 013839
- Product name
- 3-Fluoro-4-methoxybenzyl bromide
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 2707-B-34
- Product name
- 3-Fluoro-4-methoxybenzyl bromide
- Purity
- 98%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 008958
- Product name
- 3-Fluoro-4-methoxybenzyl bromide
- Purity
- 98%
- Packaging
- 5g
- Price
- $23
- Updated
- 2021/12/16
- Product number
- 013839
- Product name
- 3-Fluoro-4-methoxybenzyl bromide
- Packaging
- 5g
- Price
- $30
- Updated
- 2021/12/16
3-FLUORO-4-METHOXYBENZYL BROMIDE Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
96047-32-4
331-61-3
The general procedure for the synthesis of 3-fluoro-4-methoxybenzyl bromide from (3-fluoro-4-methoxyphenyl)methanol was as follows: at room temperature, (3-fluoro-4-methoxyphenyl)methanol (2.35 g, 15.05 mmol) and triethylamine (3.15 mL, 22.58 mmol) were dissolved in anhydrous dichloromethane (50 mL). Subsequently, methanesulfonyl chloride (1.41 mL, 18.06 mmol) was added dropwise. After 15 minutes of reaction, the reaction mixture was diluted with dichloromethane (50 mL) and the organic layer was washed with saturated aqueous sodium bicarbonate solution. The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was dissolved in anhydrous acetone (100 mL), excess lithium bromide was added and the mixture was heated to reflux for 30 minutes. After the reaction was complete, the solution was cooled and the solvent was evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water and the aqueous layer was extracted twice with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 3-fluoro-4-methoxybenzyl bromide (3.00 g, 91% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ7.16-7.07 (2H, m), 6.90 (1H, dd, J=8.3,8.4Hz), 4.45 (2H, s), 3.89 (3H, s).
References
[1] Patent: WO2017/155909, 2017, A1. Location in patent: Paragraph 0120
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 24, p. 6842 - 6846
[3] Chemical Biology and Drug Design, 2016, p. 97 - 109
3-FLUORO-4-METHOXYBENZYL BROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FLUORO-4-METHOXYBENZYL BROMIDE manufacturers
- Product
- 3-FLUORO-4-METHOXYBENZYL BROMIDE 331-61-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-03
- Product
- 3-FLUORO-4-METHOXYBENZYL BROMIDE 331-61-3
- Price
- US $1.00/KG
- Min. Order
- 1IU
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07