5-NITROSO-8-HYDROXYQUINOLINE
- Product Name
- 5-NITROSO-8-HYDROXYQUINOLINE
- CAS No.
- 3565-26-2
- Chemical Name
- 5-NITROSO-8-HYDROXYQUINOLINE
- Synonyms
- RMH-79;NSC 3852;hydroniii;Hydron III;5-NITROSO-OXINE;5-nitroso-8-quinolino;5-Nitrosochinolin-8-ol;5-NITROSO-8-QUINOLINOL;5-Nitroso-8-cinnolinol;5-nitrosoquinolin-8-ol
- CBNumber
- CB1711909
- Molecular Formula
- C9H6N2O2
- Formula Weight
- 174.16
- MOL File
- 3565-26-2.mol
5-NITROSO-8-HYDROXYQUINOLINE Property
- Melting point:
- 245 °C
- Boiling point:
- 305.12°C (rough estimate)
- Density
- 1.40
- refractive index
- 1.5651 (estimate)
- storage temp.
- Store at RT
- solubility
- insoluble in EtOH; insoluble in H2O; ≥7.35 mg/mL in DMSO
- form
- solid
- color
- Needles from EtOH
- CAS DataBase Reference
- 3565-26-2(CAS DataBase Reference)
- EPA Substance Registry System
- 8-Quinolinol, 5-nitroso- (3565-26-2)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 5-40-20/21/22
- Safety Statements
- 36/37
- Toxicity
- mmo-sat 1 mmol/plate MUREAV 164,263,86
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 13856
- Product name
- 5-Nitroso-8-quinolinol
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 13856
- Product name
- 5-Nitroso-8-quinolinol
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 13856
- Product name
- 5-Nitroso-8-quinolinol
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $213
- Updated
- 2024/03/01
- Product number
- 256054
- Product name
- NSC 3852
- Packaging
- 10mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- N546580
- Product name
- 5-Nitroso-quinolin-8-ol
- Packaging
- 100mg
- Price
- $140
- Updated
- 2021/12/16
5-NITROSO-8-HYDROXYQUINOLINE Chemical Properties,Usage,Production
Chemical Properties
slightly yellow to yellow-green powder
Uses
5-NITROSO-8-HYDROXYQUINOLINE is shown to have cell differentiation and antiproliferative activity in human breast cancer cells in tissue culture and antitumor activity in mice bearing P388 and L1210 leukemic cells.
Definition
ChEBI: 5-nitroso-8-quinolinol is a hydroxyquinoline.
Biological Activity
Histone deacetylase inhibitor. Causes cell differentiation and antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo .
Safety Profile
Poison by intravenous and intraperitoneal routes. Many nitroso compounds are carcinogens. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
storage
Room temperature
References
[1]. martirosyan a, leonard s, shi x, et al. actions of a histone deacetylase inhibitor nsc3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in mcf-7 human mammary tumor cells. j pharmacol exp ther, 2006, 317(2): 546-552.
[2]. strobl js, seibert cw, li y, et al. inhibition of toxoplasma gondii and plasmodium falciparum infections in vitro by nsc3852, a redox active antiproliferative and tumor cell differentiation agent. j parasitol, 2009, 95(1): 215-223.
5-NITROSO-8-HYDROXYQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-NITROSO-8-HYDROXYQUINOLINE manufacturers
- Product
- 5-nitrosoquinolin-8-ol 3565-26-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-02-14