5-NITROSO-8-HYDROXYQUINOLINE

ChemicalBook > CAS DataBase List > 5-NITROSO-8-HYDROXYQUINOLINE

5-NITROSO-8-HYDROXYQUINOLINE

Product Name: 5-NITROSO-8-HYDROXYQUINOLINE
CAS No.: 3565-26-2
Chemical Name: 5-NITROSO-8-HYDROXYQUINOLINE
Synonyms: RMH-79;NSC 3852;hydroniii;Hydron III;5-NITROSO-OXINE;5-nitroso-8-quinolino;5-Nitrosochinolin-8-ol;5-NITROSO-8-QUINOLINOL;5-Nitroso-8-cinnolinol;5-nitrosoquinolin-8-ol
CBNumber: CB1711909
Molecular Formula: C9H6N2O2
Formula Weight: 174.16
MOL File: 3565-26-2.mol

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5-NITROSO-8-HYDROXYQUINOLINE Property

Melting point:: 245 °C
Boiling point:: 305.12°C (rough estimate)
Density: 1.40
refractive index: 1.5651 (estimate)
storage temp.: Store at RT
solubility: insoluble in EtOH; insoluble in H2O; ≥7.35 mg/mL in DMSO
form: solid
color: Needles from EtOH
CAS DataBase Reference: 3565-26-2(CAS DataBase Reference)
EPA Substance Registry System: 8-Quinolinol, 5-nitroso- (3565-26-2)

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Safety

Hazard Codes: Xn
Risk Statements: 5-40-20/21/22
Safety Statements: 36/37
Toxicity: mmo-sat 1 mmol/plate MUREAV 164,263,86

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13856
Product name: 5-Nitroso-8-quinolinol
Purity: ≥95%
Packaging: 10mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 13856
Product name: 5-Nitroso-8-quinolinol
Purity: ≥95%
Packaging: 50mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 13856
Product name: 5-Nitroso-8-quinolinol
Purity: ≥95%
Packaging: 100mg
Price: $213
Updated: 2024/03/01

Usbiological

Product number: 256054
Product name: NSC 3852
Packaging: 10mg
Price: $290
Updated: 2021/12/16

TRC

Product number: N546580
Product name: 5-Nitroso-quinolin-8-ol
Packaging: 100mg
Price: $140
Updated: 2021/12/16

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5-NITROSO-8-HYDROXYQUINOLINE Chemical Properties,Usage,Production

Chemical Properties

slightly yellow to yellow-green powder

Uses

5-NITROSO-8-HYDROXYQUINOLINE is shown to have cell differentiation and antiproliferative activity in human breast cancer cells in tissue culture and antitumor activity in mice bearing P388 and L1210 leukemic cells.

Definition

ChEBI: 5-nitroso-8-quinolinol is a hydroxyquinoline.

Biological Activity

Histone deacetylase inhibitor. Causes cell differentiation and antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo .

Safety Profile

Poison by intravenous and intraperitoneal routes. Many nitroso compounds are carcinogens. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

storage

Room temperature

References

[1]. martirosyan a, leonard s, shi x, et al. actions of a histone deacetylase inhibitor nsc3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in mcf-7 human mammary tumor cells. j pharmacol exp ther, 2006, 317(2): 546-552.
[2]. strobl js, seibert cw, li y, et al. inhibition of toxoplasma gondii and plasmodium falciparum infections in vitro by nsc3852, a redox active antiproliferative and tumor cell differentiation agent. j parasitol, 2009, 95(1): 215-223.

5-NITROSO-8-HYDROXYQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-NITROSO-8-HYDROXYQUINOLINE manufacturers

Career Henan Chemical Co

Product: 5-nitrosoquinolin-8-ol 3565-26-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons
Release date: 2020-02-14

3565-26-2, 5-NITROSO-8-HYDROXYQUINOLINERelated Search:

(2E)-3-(4-METHOXY-3-([(5-NITRO-8-QUINOLINYL)OXY]METHYL)PHENYL)-2-PROPENOIC ACID Nitroxoline CHEMBRDG-BB 6613830 TIMTEC-BB SBB006384 METHYL 5-([(5-NITRO-8-QUINOLINYL)OXY]METHYL)-2-FUROATE 5,7-DINITROQUINOLIN-8-OL 4-METHOXY-3-([(5-NITRO-8-QUINOLINYL)OXY]METHYL)BENZALDEHYDE TIMTEC-BB SBB006345 5-([(5-NITRO-8-QUINOLINYL)OXY]METHYL)-2-FUROIC ACID 5-NITROSO-8-HYDROXYQUINOLINE 8-METHOXY-5-NITROQUINOLINE

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5-NITROSO-8-HYDROXYQUINOLINE 95+%

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3565-26-2