ChemicalBook > CAS DataBase List > 5-NITROSO-8-HYDROXYQUINOLINE

5-NITROSO-8-HYDROXYQUINOLINE

Product Name
5-NITROSO-8-HYDROXYQUINOLINE
CAS No.
3565-26-2
Chemical Name
5-NITROSO-8-HYDROXYQUINOLINE
Synonyms
RMH-79;NSC 3852;hydroniii;Hydron III;5-NITROSO-OXINE;5-nitroso-8-quinolino;5-Nitrosochinolin-8-ol;5-NITROSO-8-QUINOLINOL;5-Nitroso-8-cinnolinol;5-nitrosoquinolin-8-ol
CBNumber
CB1711909
Molecular Formula
C9H6N2O2
Formula Weight
174.16
MOL File
3565-26-2.mol
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5-NITROSO-8-HYDROXYQUINOLINE Property

Melting point:
245 °C
Boiling point:
305.12°C (rough estimate)
Density 
1.40
refractive index 
1.5651 (estimate)
storage temp. 
Store at RT
solubility 
insoluble in EtOH; insoluble in H2O; ≥7.35 mg/mL in DMSO
form 
solid
color 
Needles from EtOH
CAS DataBase Reference
3565-26-2(CAS DataBase Reference)
EPA Substance Registry System
8-Quinolinol, 5-nitroso- (3565-26-2)
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Safety

Hazard Codes 
Xn
Risk Statements 
5-40-20/21/22
Safety Statements 
36/37
Toxicity
mmo-sat 1 mmol/plate MUREAV 164,263,86
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13856
Product name
5-Nitroso-8-quinolinol
Purity
≥95%
Packaging
10mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
13856
Product name
5-Nitroso-8-quinolinol
Purity
≥95%
Packaging
50mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
13856
Product name
5-Nitroso-8-quinolinol
Purity
≥95%
Packaging
100mg
Price
$213
Updated
2024/03/01
Usbiological
Product number
256054
Product name
NSC 3852
Packaging
10mg
Price
$290
Updated
2021/12/16
TRC
Product number
N546580
Product name
5-​Nitroso-​quinolin-​8-​ol
Packaging
100mg
Price
$140
Updated
2021/12/16
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5-NITROSO-8-HYDROXYQUINOLINE Chemical Properties,Usage,Production

Chemical Properties

slightly yellow to yellow-green powder

Uses

5-NITROSO-8-HYDROXYQUINOLINE is shown to have cell differentiation and antiproliferative activity in human breast cancer cells in tissue culture and antitumor activity in mice bearing P388 and L1210 leukemic cells.

Definition

ChEBI: 5-nitroso-8-quinolinol is a hydroxyquinoline.

Biological Activity

Histone deacetylase inhibitor. Causes cell differentiation and antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo .

Safety Profile

Poison by intravenous and intraperitoneal routes. Many nitroso compounds are carcinogens. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

storage

Room temperature

References

[1]. martirosyan a, leonard s, shi x, et al. actions of a histone deacetylase inhibitor nsc3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in mcf-7 human mammary tumor cells. j pharmacol exp ther, 2006, 317(2): 546-552.
[2]. strobl js, seibert cw, li y, et al. inhibition of toxoplasma gondii and plasmodium falciparum infections in vitro by nsc3852, a redox active antiproliferative and tumor cell differentiation agent. j parasitol, 2009, 95(1): 215-223.

5-NITROSO-8-HYDROXYQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-NITROSO-8-HYDROXYQUINOLINE Suppliers

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View Lastest Price from 5-NITROSO-8-HYDROXYQUINOLINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
5-Nitroso-8-hydroxyquinoline 3565-26-2
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-19
Career Henan Chemical Co
Product
5-nitrosoquinolin-8-ol 3565-26-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons
Release date
2020-02-14

3565-26-2, 5-NITROSO-8-HYDROXYQUINOLINERelated Search:

(2E)-3-(4-METHOXY-3-([(5-NITRO-8-QUINOLINYL)OXY]METHYL)PHENYL)-2-PROPENOIC ACID Nitroxoline CHEMBRDG-BB 6613830 TIMTEC-BB SBB006384 METHYL 5-([(5-NITRO-8-QUINOLINYL)OXY]METHYL)-2-FUROATE 5,7-DINITROQUINOLIN-8-OL 4-METHOXY-3-([(5-NITRO-8-QUINOLINYL)OXY]METHYL)BENZALDEHYDE TIMTEC-BB SBB006345 5-([(5-NITRO-8-QUINOLINYL)OXY]METHYL)-2-FUROIC ACID 5-NITROSO-8-HYDROXYQUINOLINE 8-METHOXY-5-NITROQUINOLINE

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