ChemicalBook > CAS DataBase List > O-DESMETHYLGALANTHAMINE

O-DESMETHYLGALANTHAMINE

Product Name
O-DESMETHYLGALANTHAMINE
CAS No.
60755-80-8
Chemical Name
O-DESMETHYLGALANTHAMINE
Synonyms
Sanguinine;O-Demethylgalantamine;O-methyl-galanthamine;Galantamine Impurity 7;Galantamine Impurity 6;Galantamine Impurity 3;O-Demethyl-galanthamine;O-DESMETHYLGALANTHAMINE;6-O-Demethylgalanthamine;Galantamine O-Desmethyl Impurity
CBNumber
CB1712906
Molecular Formula
C16H19NO3
Formula Weight
273.33
MOL File
60755-80-8.mol
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O-DESMETHYLGALANTHAMINE Property

Melting point:
227-230°C (dec.)
Boiling point:
451.9±45.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO: soluble
form 
A solid
pka
9.39±0.40(Predicted)
color 
White to off-white
CAS DataBase Reference
60755-80-8
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D292030
Product name
O-DesmethylGalanthamine
Packaging
2mg
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21272
Product name
O-Desmethyl galanthamine
Packaging
5mg
Price
$125
Updated
2021/12/16
AK Scientific
Product number
2925CC
Product name
Sanguinine
Packaging
2mg
Price
$137
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21272
Product name
O-Desmethyl galanthamine
Packaging
10mg
Price
$230
Updated
2021/12/16
AK Scientific
Product number
2925CC
Product name
Sanguinine
Packaging
10mg
Price
$360
Updated
2021/12/16
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O-DESMETHYLGALANTHAMINE Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Powder

Uses

A metabolite of Galanthamine, a selective acetylcholinesterase inhibitor

Uses

A metabolite of Galanthamine (G188500), a selective acetylcholinesterase inhibitor.

Uses

Sanguinine has a more potent acetylcholinesterase inhibitory activity than galanthamine due to an extra hydroxyl group available for potential interaction with acetylcholinesterase. Sanguinine, in turn, is 10-fold more selective than galanthamine for acetylcholinesterase (AChE) vs. butyrylcholinesterase (BuChE). The lack of AChE inhibitory activity of lycoramine and epinorlicoramine could be due to the occurrence of a double bond in ring C, which does not allow these alkaloids to have the same spatial configuration as the active alkaloids of this series.

Definition

ChEBI: Sanguinine is a benzazepine.

O-DESMETHYLGALANTHAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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60755-80-8, O-DESMETHYLGALANTHAMINERelated Search:

Galanthaminium, 7-methyl-, iodide Epigalanthamine N-Oxide AKOS 224-01 AKOS 229-01 Galantamine Hydrobromide (-)-Galanthaminyl (-)-Camphanate Galanthamine O-Desmethyl Galanthamine b-D-Glucuronide AKOS 228-20 Galanthamine-N-oxide O-DESMETHYLGALANTHAMINE

  • (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-11-Methyl-6H-benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol
  • (4aS,8aS)-11-Methyl-4aα,5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzoazepine-3,6β-diol
  • (8aS)-5,6,9,10,11,12-Hexahydro-11-methyl-4aαH-benzofuro[3a,3,2-ef][2]benzazepine-3,6β-diol
  • 6-O-Demethylgalanthamine
  • 10-Methyl-galantham-1-ene-3b,6-diol
  • O-Demethyl-galanthamine
  • Sanguinine
  • 10-Methyl-galantham-1-ene-3,6-diol
  • O-DESMETHYLGALANTHAMINE
  • Galantamine O-Desmethyl Impurity
  • Galantamine Impurity 7
  • O-Demethylgalantamine
  • 6H-Benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol, 4a,5,9,10,11,12-hexahydro-11-methyl-, (4aS,6R,8aS)-
  • O-Desmethyl GalantamineQ: What is O-Desmethyl Galantamine Q: What is the CAS Number of O-Desmethyl Galantamine Q: What is the storage condition of O-Desmethyl Galantamine Q: What are the applications of O-Desmethyl Galantamine
  • Galantamine Impurity 6
  • Cholinesterase (ChE),anti-acetylcholinesterase,O Desmethyl Galanthamine,Inhibitor,galanthamine-type,ODesmethyl Galanthamine,O-Desmethyl Galanthamine,alkaloids,inhibit
  • Galantamine Impurity 3
  • O-methyl-galanthamine
  • O-Desmethyl Galanthamine, 10 mM in DMSO
  • (4aS,6R,8aS)-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepine-3,6-diol
  • 60755-80-8
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