4-(Bromomethyl)benzeneboronic acid pinacol ester
- Product Name
- 4-(Bromomethyl)benzeneboronic acid pinacol ester
- CAS No.
- 138500-85-3
- Chemical Name
- 4-(Bromomethyl)benzeneboronic acid pinacol ester
- Synonyms
- 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)benzyl BroMide;4-(Bromomethyl)phenylboronic acid pinacol;4-BROMOMETHYLPHENYLBORONIC ACID, PINACOL ESTER;4-(BROMOMETHYL)BENZENEBORONIC ACID PINACOL ESTER;4-Bromomethylphenylboronic acid pinacol ester 95%;4-(BROMOMETHYL)BENZENEBORONICACIDPINACOLESTER,95%;tert-butyl 3-allyl-3-hydroxyazetidine-61-carboxylate;4-(bromomethyl)phenylboronic acid pinacol cyclic ester;4-(Bromomethyl)benzeneboronic acid pinacol cyclic ester;4-Bromomethylphenylboronic acid, pinacol ester - [B1882]
- CBNumber
- CB1713271
- Molecular Formula
- C13H18BBrO2
- Formula Weight
- 297
- MOL File
- 138500-85-3.mol
4-(Bromomethyl)benzeneboronic acid pinacol ester Property
- Melting point:
- 85-89 °C
- Boiling point:
- 351.2±25.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Toluene
- form
- powder
- color
- white to off-white
- BRN
- 7921808
- InChI
- InChI=1S/C13H18BBrO2/c1-12(2)13(3,4)17-14(16-12)11-7-5-10(9-15)6-8-11/h5-8H,9H2,1-4H3
- InChIKey
- CBUOGMOTDGNEAW-UHFFFAOYSA-N
- SMILES
- O1C(C)(C)C(C)(C)OB1C1=CC=C(CBr)C=C1
- CAS DataBase Reference
- 138500-85-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- 3261
- WGK Germany
- 3
- Hazard Note
- Harmful/Irritant/Keep Cold
- TSCA
- No
- HazardClass
- IRRITANT
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H314Causes severe skin burns and eye damage
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 718513
- Product name
- 4-Bromomethylphenylboronic acid pinacol ester
- Purity
- 95%
- Packaging
- 1g
- Price
- $122
- Updated
- 2025/07/31
- Product number
- 718513
- Product name
- 4-Bromomethylphenylboronic acid pinacol ester
- Purity
- 95%
- Packaging
- 5g
- Price
- $206
- Updated
- 2025/07/31
- Product number
- T2945
- Product name
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- T2945
- Product name
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $89
- Updated
- 2025/07/31
- Product number
- B685680
- Product name
- 2-[4-(Bromomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- Packaging
- 2.5g
- Price
- $165
- Updated
- 2021/12/16
4-(Bromomethyl)benzeneboronic acid pinacol ester Chemical Properties,Usage,Production
Description
4-(Bromomethyl)benzeneboronic acid pinacol ester can be used as an active oxygen source in biological assays, such as functional assays, because it generates reactive oxygen species and can act as a fluorescence probe for detection of biological samples.
Chemical Properties
White powder
Uses
4-(Bromomethyl)benzeneboronic acid pinacol ester is used in the synthesis of metalloproteinase-13 inhibitors in the treatment of osteoarthritis.
Synthesis
Pinacol p-tolueneborate (10.91g, 50.0mmol), bromosuccinimide (NBS, 9.91g, 55.0mmol), and azobisisobutyronitrile (AIBN, 0.44g, 2.0mmol) were dissolved in dry of carbon tetrachloride (CCl4, 200 mL), stirred at reflux for 14 hours. The mixture was filtered, the solvent was evaporated, and the mixture was dissolved in ethyl acetate (200 mL). Wash once with distilled water (100 mL) and saturated sodium chloride aqueous solution (100 mL), dry with anhydrous sodium sulfate, and rotary evaporate. Finally, use petroleum ether as the eluent for column chromatography separation to obtain 4-(Bromomethyl)benzeneboronic acid pinacol ester (11.30g, yield 76.1%).
References
[1] Patent: WO2013/25885, 2013, A1. Location in patent: Paragraph 0086
[2] Synthetic Communications, 2002, vol. 32, # 17, p. 2669 - 2676
[3] Patent: EP2450354, 2012, A1
4-(Bromomethyl)benzeneboronic acid pinacol ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(Bromomethyl)benzeneboronic acid pinacol ester manufacturers
- Product
- 4-(Bromomethyl)benzeneboronic acid pinacol ester 138500-85-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000kg
- Release date
- 2025-04-17
- Product
- 4-(Bromomethyl)benzeneboronic acid pinacol ester 138500-85-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 4-(Bromomethyl)benzeneboronic acid pinacol ester 138500-85-3
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-10