(2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER

Product Name: (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER
CAS No.: 377780-72-8
Chemical Name: (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER
Synonyms: 2-[2-(Bromomethyl)phenyl]-4,4,5,5-tetra;(2-BROMOMETHYLPHENYL)BORONIC ACID, PICOL ESTER;(2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER;2-(BROMOMETHYL)BENZENEBORONIC ACID PINACOL ESTER;2-(Bromomethyl)benzeneboronicacidpinacolcyclicester;2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide;2-(2-(Bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1,3,2-Dioxaborolane, 2-[2-(bromomethyl)phenyl]-4,4,5,5-tetramethyl-;2-[2-(Bromomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl bromide
CBNumber: CB7134151
Molecular Formula: C13H18BBrO2
Formula Weight: 297
MOL File: 377780-72-8.mol

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(2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER Property

Melting point:: 78-80°C
Boiling point:: 360.6±25.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Sparingly)
form: solid
color: white to off-white
CAS DataBase Reference: 377780-72-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 2
Hazard Note: Irritant/Keep Cold
TSCA: No
HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 716235
Product name: 2-Bromomethylphenylboronic acid pinacol ester
Purity: 95%
Packaging: 1g
Price: $180
Updated: 2025/07/31

TCI Chemical

Product number: T3393
Product name: 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $122
Updated: 2025/07/31

TCI Chemical

Product number: T3393
Product name: 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $360
Updated: 2025/07/31

TRC

Product number: B683635
Product name: 2-Bromomethylphenylboronic acid pinacol ester
Packaging: 500mg
Price: $80
Updated: 2021/12/16

TRC

Product number: B683635
Product name: 2-Bromomethylphenylboronic acid pinacol ester
Packaging: 2.5g
Price: $155
Updated: 2021/12/16

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(2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER Chemical Properties,Usage,Production

Uses

2-Bromomethylphenylboronic Acid Pinacol Ester is an intermediate used to prepare [(fluorophenylcarbamoyl)pyridinylsulfanylmethyl]phenylboronic acid and noncompetitive boronic acid antagonist of CXCR1 and CXCR2.

Synthesis

76-09-5

16419-60-6

377780-72-8

To a three-neck flask equipped with a Dean-Stark splitter was added 30 mL of toluene followed by 2-methylphenylboronic acid (0.21 g, 1.55 mmol) and pinacol (0.22 g, 1.86 mmol). The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the mixture was washed three times with 30 mL of water to remove unreacted pinacol and phenylboronic acid. The organic phase was separated and the toluene solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was dissolved in 50 mL of dichloromethane and washed again with 30 mL of water. Anhydrous sodium sulfate was added to the organic phase to dry, and the dried solution was evaporated under reduced pressure to give 0.32 g of crude product. The resulting crude product (0.32 g, 1.47 mmol), N-bromosuccinimide (NBS, 0.39 g, 2.2 mmol) and azobisisobutyronitrile (AIBN, 0.003 g, 0.018 mmol) were dissolved in 10 mL of acetonitrile. The reaction solution was refluxed at 90 °C for 2 hours. After the reaction was completed, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography using petroleum ether (60~90 °C)/ethyl acetate (v/v = 1:1) as eluent to obtain the target product 2-bromoethylphenylboronic acid pinacol ester as white solid (0.53 g, 80% yield).

References

[1] Patent: CN107383078, 2017, A. Location in patent: Paragraph 0058; 0063; 0064; 0065; 0066; 0067; 0068

(2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER Suppliers

China 106 France 1 Germany 2 India 3 Japan 2 Jordan 1 Ukraine 1 United Kingdom 5 United States 22 Global 143

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View Lastest Price from (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (2-Bromomethylphenyl)boronic acid pinacol ester 377780-72-8
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-03

Zhuozhou Wenxi import and Export Co., Ltd

Product: (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER 377780-72-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER 377780-72-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

377780-72-8, (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTERRelated Search:

4-Chloro-3-methoxyphenylboronic acid pinacolester 4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)CYCLOHEX-3-ENE-1-CARBOXYLIC ACID ETHYL ESTER 2-[(3-chlorophenyl)Methyl]-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane 4-ISOXAZOLEBORONIC ACID PINACOL ESTER Ethyl 2-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzoate methyl 2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 2-(2,5-DibroMophenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane 3-Methoxybenzylboronic acid pinacol ester 2-Bromomethyl-4-fluorophenylboronic acid pinacol ester (2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER 2-Bromomethylphenylboronic acid (3-BROMOMETHYLPHENYL)BORONIC ACID PINACOL ESTER 2-(2-(Bromomethyl)-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-(2-(Bromomethyl)-4-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-(BROMOMETHYL)-4-(TRIFLUOROMETHYL)PHENYL BORONIC ACID PINACOL ESTER 3,4-DIFLUORO-2-(BROMOMETHYL)PHENYL BORONIC ACID PINACOL ESTER 2,5-DIFLUORO-6-(BROMOMETHYL)PHENYL BORONIC ACID PINACOL ESTER

2-(BROMOMETHYL)BENZENEBORONIC ACID PINACOL ESTER

(2-BROMOMETHYLPHENYL)BORONIC ACID, PINACOL ESTER

2-(Bromomethyl)benzeneboronicacidpinacolcyclicester

2-(2-(Bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide

2-[2-(Bromomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl bromide

(2-BROMOMETHYLPHENYL)BORONIC ACID, PICOL ESTER

2-[2-(Bromomethyl)phenyl]-4,4,5,5-tetra

1,3,2-Dioxaborolane, 2-[2-(bromomethyl)phenyl]-4,4,5,5-tetramethyl-

377780-72-8

1385000-85-3

C13H18BBrO2

Aryl Boronate Esters

Boronate Esters

Boronic Acids and Derivatives

Chemical Synthesis

Organometallic Reagents

Boronic acid

blocks

BoronicAcids

Bromides

Boronic acids